Dapagliflozin+metformin+glimepiride
About Dapagliflozin+metformin+glimepiride
Dapagliflozin+glimepiride+metformin is used to treat type-2 diabetes mellitus as an adjunct to diet and exercise. Type 2 diabetes mellitus is a medical condition in which blood glucose levels are elevated due to insulin deficiency, insulin resistance, or both.
Dapagliflozin+glimepiride+metformin contains remogliflozin and metformin. Remogliflozin helps in removing excess sugar from the body via urine. Metformin reduces the sugar production in liver cells and delays sugar absorption from the intestines.
Take Dapagliflozin+glimepiride+metformin as prescribed by your doctor. Dapagliflozin+glimepiride+metformin may cause side effects, such as stomach upset, low blood sugar, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, consult your doctor if you experience these side effects persistently.
Consult your doctor if you are pregnant or breastfeeding. Limited information is available regarding the usage of Dapagliflozin+glimepiride+metformin in children, so please consult a doctor if you have any concerns. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.
Uses of Dapagliflozin+metformin+glimepiride
Medicinal Benefits
- Efficiently lowers blood sugar levels in those with type 2 diabetes.
- Lowers glucose levels after meals and during fasting.
- Reduces insulin resistance and increases insulin sensitivity.
- Reduces excess sugar by encouraging the excretion of glucose in the urine.
- Encourages modest weight reduction or weight neutrality.
- Reduces the risk of diabetes complications when used consistently.
Directions for Use
- Take Dapagliflozin+glimepiride+metformin with food to reduce stomach upset or gastrointestinal side effects.
- Recommended to take it once daily in the morning or as advised by your doctor.
- Swallow the medicine as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Dapagliflozin+metformin+glimepiride
- Headache
- Nausea
- Stomach upset
- Vomiting
- Abdominal pain
- Allergic reactions
- Hypoglycaemia (low blood sugar)
Medicines Containing this Salt
View AllDrug Warnings
- Dapagliflozin+glimepiride+metformin should be avoided if you are allergic to any of the medicines or their components.
- Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements, to rule out any side effects.
- It is unknown whether Dapagliflozin+glimepiride+metformin can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding.
- It is not recommended for use in children below 18 years of age.
- Avoid drinking alcohol while on Dapagliflozin+glimepiride+metformin as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).
- Inform your doctor if you have any liver/kidney disease, heart problems, and hypertension before taking Dapagliflozin+glimepiride+metformin.
Drug Interactions
Drug-Drug Interactions: Dapagliflozin+glimepiride+metformin may interact with certain medications, increasing side effects.
- Water pills (furosemide, hydrochlorothiazide)
• Potential effect: May cause low blood pressure and dehydration. - Anti-diabetic drugs (insulin glargine)
• Potential effect: May increase the risk of hypoglycemia (low blood sugar levels) - Drugs used for hypertension (captopril, telmisartan)
• Potential effect: May increase glucose-lowering effect.
Drug-Food Interactions:
Alcohol: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic acidosis. So, avoid intake of alcoholic beverages with Dapagliflozin+glimepiride+metformin.
Drug-Disease Interactions: Inform your doctor if you have a history of the following conditions before taking Dapagliflozin+glimepiride+metformin, as it may worsen your condition or cause complications.
- Diabetic ketoacidosis (buildup of ketones, resulting in acidic blood)
- Dialysis
- Hypoglycaemia (low blood sugar levels)
- Liver/kidney problems
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol increases the impact of metformin on lactate metabolism. Hence, you should not consume excessive amounts of alcohol, either temporarily or permanently, while taking Dapagliflozin+glimepiride+metformin.
Pregnancy
consult your doctorThere are no adequate studies on the effect of Dapagliflozin+glimepiride+metformin in pregnancy. If you are pregnant or planning pregnancy, inform your doctor before taking Dapagliflozin+glimepiride+metformin.
Breast Feeding
consult your doctorDapagliflozin+glimepiride+metformin is generally not recommended in breastfeeding. Hence, if you are breastfeeding, inform your doctor before using Dapagliflozin+glimepiride+metformin.
Driving
cautionDapagliflozin+glimepiride+metformin usually does not affect your ability to drive or operate machinery.
Liver
cautionDapagliflozin+glimepiride+metformin may cause lactic acidosis due to metformin accumulation. The risk increases with hepatic insufficiency. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
cautionRenal impairment also increases the risk of lactic acidosis. Hence, Dapagliflozin+glimepiride+metformin should be used cautiously if you have kidney problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
unsafeDapagliflozin+glimepiride+metformin is not recommended for children below 18 years as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
Healthy eating habits:
- Eat a low-glycemic, well-balanced diet rich in pulses, veggies, and whole grains.
- To prevent blood sugar surges and upset stomachs, eat small, frequent meals.
- Limit refined carbohydrates, sweetened beverages, and sugary foods.
- Add lean proteins (fish, eggs, and dairy) to enhance glucose regulation.
Lifestyle changes:
- Engage in regular exercise, such as yoga, walking, or gentle exercise, to help control your blood sugar.
- Maintain a healthy weight by eating well and exercising.
- To avoid dehydration and urinary tract infections, drink enough water.
- Refrain from smoking and consuming alcohol.
Sugar monitoring:
- As directed by your physician, routinely check your blood sugar levels throughout fasting and after meals.
- Keep an eye out for signs of low blood sugar, such as sweating and dizziness, especially if you're on other diabetic medications.
- To evaluate long-term control, have your HbA1c checked every three months.
Physical activity:
- On most days, get in at least 30 minutes of moderate activity (cycling, brisk walking).
- To increase insulin sensitivity, incorporate strength training two to three times per week.
- Stretching or yoga might help you feel less stressed and more flexible.
Special Advise
- Dapagliflozin+glimepiride+metformin may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Always carry a sugary food such as candy or fruit juice and consume them if you experience hypoglycaemia.
- Your doctor may advise frequent blood tests to check your blood sugar levels.
Patients Concern
Disease/Condition Glossary
Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Individuals middle-aged or older are most likely to suffer from type 2 diabetes, which is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision.
FAQs
Dapagliflozin+glimepiride+metformin is used for the treatment of Type II Diabetes.
Dapagliflozin+glimepiride+metformin contains Dapagliflozin, Metformin, and Glimepiride, which work by increasing the amounts of certain natural substances that lower blood sugar when it is high.
Please consult your doctor if you have concerns and for more information on this.
If you forget to take Dapagliflozin+glimepiride+metformin, take it as soon as you remember. However, if it is time for the next dose, avoid taking it and do not double dose to make up for the missed dose. Taking an overdose might cause your sugar level to fall down rapidly.















