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About DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE belongs to the class of combination medication called NSAIDs (non-steroidal anti-inflammatory drugs) used to relieve pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis. Besides this, it also helps treat muscle pain, tooth pain during dental surgery, menstrual period pain/cramps, ear pain and migraine headaches. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Arthritis is the tenderness and swelling in the joints which causes pain and joint stiffness.

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is a combination of three drugs, namely: Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of a chemical messenger, known as cyclo-oxygenase (COX) enzymes that make other chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain, swelling and fever. By blocking COX enzyme's effect, lesser prostaglandins are produced, which reduces mild to moderate pain, inflammation and fever. Serratiopeptidase acts as a mucolytic (dissolves thick protein at the injured/affected site) and anti-inflammatory agent thereby decreasing swelling at the painful site. 
 
You are advised to take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE for as long as your doctor has prescribed it for you. In some cases, DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause certain common side-effects such as nausea, vomiting, stomach pain, headache, indigestion and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause drowsiness and dizziness, so drive with caution. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol with DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Uses of DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE

Pain and inflammation associated with osteoarthritis, muscle pain, joint pain, rheumatoid arthritis, mild migraine, dental pain, etc.

Medicinal Benefits

DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is a combination of three drugs, namely: Diclofenac (pain killer), Paracetamol (fever reducer) and Serratiopeptidase (protein enzyme). DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is used to relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, muscle pain, tooth pain, bone and joint pain, headache, swelling, period pain, ear pain, migraine, fever,  sore throat, nose pain, etc. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE increases the pain threshold and blood flow across the skin. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase breaks down the abnormal proteins at the site of inflammation, thereby reduces inflammation. 

Directions for Use

Take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE with food. Swallow DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as a whole with a glass of water; do not chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhoea
  • Indigestion
  • Headache

In-Depth Precautions and Warning

Drug Warnings

Do not take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you are allergic to paracetamol, diclofenac or serratiopeptidase, have/had severe heart problems, stomach ulcer or perforation, bleeding problems such as bleeding from the stomach, intestine or brain, have undergone any heart bypass surgery, have had a heart attack, blood circulation problems or inflammation of intestines. Consult your doctor if you are pregnant, planning for pregnancy or breastfeeding. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause drowsiness and dizziness, so drive only if you are alert. DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is not recommended for children less than 10 years of age as safety and effectiveness have not been established. Avoid consuming alcohol with DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it could lead to increased drowsiness and increased risk of stomach bleeding. Stop taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE unless prescribed.

Drug Interactions

Drug-Drug Interactions: DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may interact with pain killers (aspirin, ibuprofen), immunosuppressants (cyclosporine, tacrolimus), anti-psychotic (lithium), cardiac glycoside (digoxin), blood thinner (warfarin), anti-rheumatoid (methotrexate), antacid (magnesium hydroxide), anti-fungal (ketoconazole, miconazole, fluconazole, voriconazole), anti-arrhythmic (amiodarone), anti-gout (sulfinpyrazone), anti-emetic (metoclopramide, domperidone), bile acid sequestrant (cholestyramine), anti-cancer (imatinib), antibiotic (chloramphenicol), anti-progestational steroid (mifepristone), anti-diabetics, diuretics, anti-hypertensives medicines.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have stomach ulcer or perforation, bleeding problems, bypass surgery, heart attack, blood circulation problems, inflammation of intestines, anaemia, heart, kidney or liver problems.

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • IBUPROFEN
  • CYCLOSPORINE
  • TACROLIMUS
  • LITHIUM
  • DIGOXIN
  • WARFARIN
  • METHOTREXATE
  • MAGNESIUM HYDROXIDE
  • KETOCONAZOLE
  • MICONAZOLE
  • VORICONAZOLE
  • FLUCONAZOLE
  • AMIDODARONE
  • SULFINPYRAZONE
  • METOCLOPRAMIDE
  • DOMPERIDONE
  • CHOLESTYRAMINE
  • IMATINIB
  • CHLORAMPHENICOL
  • MIFEPRESTONE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consumption of alcohol while taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE as it may cause increased drowsiness.

    • Safety Warning

      Pregnancy

      caution

      Please consult your doctor if you are pregnant; your doctor will prescribe DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      Consult your doctor if you are breastfeeding; your doctor will decide whether DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE can be taken by breastfeeding mothers or not.

    • Safety Warning

      Driving

      caution

      DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      unsafe

      DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE should not be given to children less than 10 years of age, as the safety and effectiveness have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
    • Massages can also be helpful.
    • Avoid freezing and hot temperatures.
    • Avoid wearing tight-fitting clothes; instead, wear loose garments.
    • Rest well, and get plenty of sleep.
    • To avoid developing pressure sores, change your position every two hours.
    • Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20 minutes.
    • Stay hydrated, drink plenty of water.

    Patients Concern

    Disease/Condition Glossary

    Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp, it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalized (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures and arthritis.

    Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

    Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

    Ankylosing spondylitis: It causes pain and stiffness in the spine. The pain generally starts in the lower back and can spread to the neck, damaged joints or other body parts. Ankylosing spondylitis includes decreased flexibility which usually leads to a hunched-forward posture and pain in the back and joints.

    FAQs

    How does DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE work?

    DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE contains Diclofenac, Paracetamol and Serratiopeptidase. Diclofenac and Paracetamol work by blocking the effect of chemical messengers that cause pain and inflammation. Serratiopeptidase is a protein enzyme that helps break down and dissolves the abnormal proteins at the inflammation site, thereby reducing pain.

    Is DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE used to relieve arthritic pain?

    DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE is used to reduce and relieve pain and inflammation associated with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Arthritis is the tenderness and swelling in the joints.

    Does DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE cause diarrhoea?

    Diarrhoea might be a side-effect of DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

    Can I take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE for longer durations?

    DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE should not be taken for longer durations unless prescribed by the doctor. If DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE has been prescribed for longer durations, regular monitoring of kidney function, liver function and blood count is advised, particularly in elderly patients.

    I have stomach ulcers. Can I take DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE?

    Avoid taking DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE if you have ulcers in the stomach or intestines, bleeding problems or heart problems.

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    DICLOFENAC+PARACETAMOL+SERRATIOPEPTIDASE

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