Domperidone+lansoprazole
About Domperidone+lansoprazole
Domperidone+lansoprazole is a prescription medication in oral capsule form used to treat gastroesophageal reflux disease (GERD), acid reflux, and peptic ulcers. It helps relieve symptoms such as heartburn, difficulty swallowing, and a persistent sour taste in the mouth by managing excess stomach acid and promoting digestive movement. This medicine helps heal irritation in the oesophagus and prevents damage caused by stomach acid.
For the best results, you must take Domperidone+lansoprazole consistently every day at the same time, exactly as directed by your healthcare provider. This medication is typically taken on an empty stomach, at least 30 minutes before your first meal of the day. Incorporating simple lifestyle habits, such as eating smaller portions and avoiding heavy meals late at night, can significantly improve your treatment outcomes.
While taking Domperidone+lansoprazole, you may experience mild and temporary side effects such as a headache, mild diarrhoea, nausea, or stomach discomfort. However, if you experience rare but serious symptoms like an irregular heartbeat, muscle weakness, or a severe skin rash, you should contact your doctor immediately. Do not ignore persistent or worsening symptoms.
Before starting this medicine, tell your doctor if you have a history of liver damage, kidney disease, or heart rhythm abnormalities. Do not take this if you have a gastrointestinal blockage, bleeding in your stomach or intestines, or a tumour of the pituitary gland. It is also not suitable for individuals with a known allergy to any of the active ingredients.
This medication can interact with certain antifungal treatments, blood thinners, and heart medications, which may alter its effectiveness or increase the risk of side effects. Avoid consuming alcohol or smoking while on this treatment, as both can worsen stomach irritation and increase acid production. If you are pregnant, planning a pregnancy, breastfeeding, or are an elderly individual, consult your doctor to ensure this medicine is safe for you.
Uses of Domperidone+lansoprazole
Medicinal Benefits
Domperidone+lansoprazole provides comprehensive relief from chronic digestive discomfort, allowing you to enjoy your meals without the fear of painful heartburn or acid indigestion.
Benefits may include:
- By addressing both high stomach acid and sluggish digestion, it delivers reliable, dual-action relief that restores comfort to your daily routine.
- It quickly calms the burning sensation in your chest and throat, helping you rest comfortably.
- By encouraging food to move smoothly out of the stomach, it prevents that heavy, uncomfortable feeling of being overly full after eating.
- It creates a low-acid environment in your stomach, which promotes the natural healing of irritated oesophageal and gastric tissues.
Directions for Use
- Take Domperidone+lansoprazole on an empty stomach or as advised by your doctor.
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow Domperidone+lansoprazole as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Domperidone+lansoprazole
Common Side Effects (Usually mild):
- Nausea
- Headache
- Mild diarrhea or loose stools
- Dizziness or mild drowsiness
Serious Side Effects (Call a doctor right away):
- A fast, pounding, or irregular heartbeat (palpitations)
- Severe, watery, or persistent diarrhoea accompanied by stomach cramps and fever
- Muscle spasms, tremors, or unusual muscle weakness, which may indicate low magnesium levels
- Signs of a severe allergic reaction, such as swelling of the face, lips, tongue, or throat, or difficulty breathing
Medicines Containing this Salt
View AllDrug Warnings
- Monitor Nutrient Levels: If you are taking Domperidone+lansoprazole for a long period (more than a year), your doctor may need to monitor your magnesium, calcium, and vitamin B12 levels regularly.
- Avoid Driving or Machinery: This medicine may cause dizziness or sleepiness; avoid driving, riding a bicycle, or operating machinery until you know how it affects your alertness.
- Report Bone Pain: Talk to your doctor immediately if you develop bone pain, as long-term use of acid-reducing medicines can slightly increase the risk of bone fractures.
- Do Not Stop Suddenly: Do not stop taking this medication abruptly, as this can cause a rebound effect, making your acid reflux symptoms return worse than before.
- Check Before Taking Pain Relievers: Consult your pharmacist before taking over-the-counter pain relievers such as ibuprofen, as these can irritate your stomach lining and reduce the benefits of Domperidone+lansoprazole.
Drug Interactions
- Antifungal medications (such as ketoconazole or itraconazole): May alter the effectiveness of Domperidone+lansoprazole.
- Blood thinners (such as warfarin): May increase the risk of bleeding; monitoring may be required.
- HIV medications (such as atazanavir or nelfinavir): May become less effective when taken with this medicine.
- Heart rhythm medications (such as amiodarone): May increase the risk of serious irregular heart rhythms.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption as it may lead to increased production of stomach acid, thereby irritates the stomach lining and worsen the symptoms.
Pregnancy
cautionDomperidone+lansoprazole is a category B pregnancy drug and is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.
Breast Feeding
unsafeDomperidone+lansoprazole is usually contraindicated in breastfeeding mothers. Therefore, please consult a doctor before taking Domperidone+lansoprazole if you are breastfeeding.
Driving
cautionDomperidone+lansoprazole may cause drowsiness in some people. Therefore, avoid driving or operating machinery if you feel drowsy after taking Domperidone+lansoprazole.
Liver
cautionTake Domperidone+lansoprazole with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.
Kidney
cautionTake Domperidone+lansoprazole with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
unsafeDomperidone+lansoprazole is not recommended for children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat Smaller Meals: Eat smaller, more frequent meals throughout the day instead of three large meals to reduce pressure on the lower oesophageal sphincter.
- Avoid Trigger Foods: Avoid common food triggers that stimulate excess acid, such as spicy, fatty, or fried foods, citrus fruits, tomatoes, chocolate, caffeine, and carbonated drinks.
- Stay Upright After Eating: Do not lie down, recline, or go to sleep for at least two to three hours after eating to keep stomach acid from travelling upward.
- Elevate Your Head While Sleeping: Elevate the head of your bed by six inches using a bed wedge or blocks to allow gravity to keep acid in your stomach while you sleep.
- Wear Loose-Fitting Clothing: Wear loose-fitting clothing around your waist to avoid putting extra pressure on your stomach, which can force acid into your oesophagus.
Special Advise
Regular blood tests are recommended while taking Domperidone+lansoprazole to monitor magnesium levels in the blood.
Domperidone+lansoprazole may cause some abnormal liver enzyme and blood values. These changes are temporary and may return to normal after treatment with Domperidone+lansoprazole is discontinued.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers, and heartburn. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: These are sores that develop on the stomach and intestine lining due to erosion of the stomach protective lining. Symptoms include nausea, appetite changes, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.
Zollinger-Ellison syndrome: It is characterized by the formation of tumours in the upper part of the small intestine, which leads to excess acid production. Symptoms include bloating, burping, weight loss, loss of appetite, nausea, and vomiting.
FAQs
Domperidone+lansoprazole is used to treat gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Domperidone+lansoprazole is a combination of two medicines namely: "Domperidone" and "Lansoprazole". Domperidone increases the movement of food in the stomach which helps to avoid the problems related to indigestion, bloating, and fullness. This medicine also restricts the action of a chemical that is responsible for the feeling of vomiting and nausea. On the other side, Lansoprazole works by blocking the action of proton pumps that are involved in producing stomach acid. Thereby, Domperidone+lansoprazole reduces the amount of acid produced by the stomach and prevents excess acid from flowing back into the food pipe. Thus, both medicines in combination provide relief from heartburn symptoms related to acid reflux.
Domperidone+lansoprazole may cause low levels of magnesium in the blood if taken for more than 3 months. If you experience involuntary muscle contractions, tiredness fits, increased heart rate or dizziness while taking Domperidone+lansoprazole, please consult a doctor immediately as these might be signs of low magnesium levels. However, regular blood tests are recommended to monitor magnesium levels in the blood while taking Domperidone+lansoprazole.
You are not recommended to take Domperidone+lansoprazole with antifungals such as ketoconazole or itraconazole as it may reduce the effectiveness of antifungal against fungal infections. However, please consult your doctor before taking Domperidone+lansoprazole with other medicines.
Domperidone+lansoprazole should be used with caution in osteoporosis (weak and brittle bones) patients as it may worsen the condition especially if Domperidone+lansoprazole is taken for more than 1 year as it increases the risk of fracture of the spine, hip or wrist. Therefore, inform your doctor if you have osteoporosis or take any steroids which may increase the risk of osteoporosis.
It is best to take whole grains food like brown rice, green vegetables, sweet potatoes, and carrots to reduce acidity.
Taking Domperidone+lansoprazole for longer than the duration recommended by your doctor may increase the risk of side effects. Prolonged use of Domperidone+lansoprazole may lead to heart-related issues due to domperidone. If taken for over a year, it may also result in hypomagnesemia (low magnesium levels), vitamin B12 deficiencies, bone fractures, and gut infections due to lansoprazole. Therefore, it is important to regularly monitor your health to determine whether you should continue taking Domperidone+lansoprazole. Always follow your doctor's advice and discuss any concerns about long-term use with them.
Yes, smoking and alcohol can increase acidity and contribute to GERD (Gastroesophageal Reflux Disease). Smoking is a major cause of GERD, while alcohol primarily triggers acid reflux episodes. Both smoking and alcohol can weaken the lower oesophageal sphincter, the muscle that keeps acid in the stomach, allowing it to flow back into the oesophagus. Smoking also reduces the amount of saliva that helps neutralize acid in the oesophagus, while alcohol can irritate the lining of both the stomach and the oesophagus. It is advisable to limit or avoid smoking and alcohol to help manage acidity and GERD.
The common side effects of Domperidone+lansoprazole include diarrhoea, nausea, vomiting, headache, dizziness, stomach pain, and constipation in some cases. Most of these side effects of Domperidone+lansoprazole do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Yes, you should take Domperidone+lansoprazole on an empty stomach, ideally 30 minutes before your morning meal. Taking it with food can significantly reduce how well the medicine is absorbed. Talk to your doctor if you have questions about your schedule.
It is highly recommended to avoid alcohol while taking Domperidone+lansoprazole. Alcohol can directly irritate your stomach lining, increase acid production, and worsen acid reflux, making the medication less effective. Avoiding alcohol can help your treatment work more effectively.
Domperidone+lansoprazole is generally not recommended during pregnancy or breastfeeding unless your doctor decides that the medical benefits clearly outweigh the potential risks to the baby. If you are pregnant or breastfeeding, talk to your doctor before starting this medication.
Yes. Domperidone+lansoprazole may cause nausea or diarrhoea as common side effects, especially during the first few days of treatment. These are usually mild and improve as your body adjusts to the medicine. Drink plenty of fluids to prevent dehydration. If diarrhoea is severe, persistent, or accompanied by fever, severe stomach pain, or bloody stools, or if nausea is severe or does not improve, consult your doctor.
Long-term use of acid-reducing medicines (usually for a year or more) can slightly increase the risk of bone fractures, especially in the hip, wrist, or spine. If you have osteoporosis or risk factors for bone loss, your doctor may recommend periodic monitoring if long-term treatment is necessary.
No, you should never crush, chew, or open the capsule. It must be swallowed whole with a glass of water to ensure the protective coating remains intact, which allows the medication to be absorbed correctly in the intestine. Ask your pharmacist about suitable alternatives if swallowing capsules is difficult.
If you experience a fast, fluttering, or irregular heartbeat, stop taking the medication and seek immediate medical care. This can be a sign of a serious heart rhythm issue that requires prompt evaluation. Talk to your doctor immediately.
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