DOMPERIDONE+PANTOPRAZOLE is composed of two medicines, namely: Domperidone and Pantoprazole. Domperidone is a prokinetic and anti-nausea agent that helps to treat indigestion and stomach pain. On the other hand, Pantoprazole is a proton pump inhibitor that reduces the excess stomach acid formation by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). DOMPERIDONE+PANTOPRAZOLE is a widely used medicine to treat peptic ulcers and gastroesophageal reflux disease (GERD). DOMPERIDONE+PANTOPRAZOLE prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn.
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and in this way reduces the feeling of bloating, or fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, that is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall responsible for the release of gastric acid secretion damaging tissues in the food pipe, stomach, and duodenum.
It should be taken as prescribed by the doctor. Like all medicines, DOMPERIDONE+PANTOPRAZOLE may cause side effects, although not everybody gets them. The most common side effects of DOMPERIDONE+PANTOPRAZOLE are diarrhoea, stomach pain, flatulence (gas), dryness in the mouth, dizziness, and headache. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.
It is recommended not to use if you are allergic to any ingredinets present in it. Prolonged intake of Pantoprazole is associated with a low level of Vitamin B12 and low magnesium. Hence yearly test of Vitamin B12 and magnesium is required if you are taking DOMPERIDONE+PANTOPRAZOLE for the long term. Use of DOMPERIDONE+PANTOPRAZOLE is contraindicated in people with lupus (autoimmune inflammatory disease). Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep fried/processed foods, carbonated drinks, acidic foods like citrus fruits/vegetables (tomatoes).
Gastroesophageal reflux disease (GERD), Heartburn due to hyperacidity, Inflammation of food pipe (esophagitis), Peptic ulcer.
DOMPERIDONE+PANTOPRAZOLE plays a vital role in preventing nausea, vomiting, stomach upset, stomach pain, peptic ulcer, and other conditions due to hyperacidity or acid reflux. Pantoprazole prevents the proton pumps gate from producing an excessive amount of stomach acid. While Domperidone stops nausea (feeling sick) and vomiting (being sick) blocking messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre.
You should avoid taking DOMPERIDONE+PANTOPRAZOLE if you are allergic to DOMPERIDONE+PANTOPRAZOLE or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. DOMPERIDONE+PANTOPRAZOLE may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of DOMPERIDONE+PANTOPRAZOLE may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B12, and magnesium deficiency. Intake of DOMPERIDONE+PANTOPRAZOLE may mask the symptom of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool) immediately consult the doctor.
Drug-Drug Interactions: DOMPERIDONE+PANTOPRAZOLE may interact with a blood thinner (e.g. clopidogrel, warfarin), antifungal (e.g. ketoconazole, voriconazole, itraconazole, posaconazole), anti-HIV drug (e.g. atazanavir, nelfinavir), iron supplements, antibiotic (e.g. ampicillin, rifampicin), heart medicine (e.g. digoxin) and anti-cancer drug (e.g. methotrexate). Let your doctor know if you are taking these medicines.
Drug-Food Interactions: DOMPERIDONE+PANTOPRAZOLE interact with St John's wort plant that is used as an anti-depressant. This plant may affect the working of DOMPERIDONE+PANTOPRAZOLE. So avoid its intake with DOMPERIDONE+PANTOPRAZOLE.
Drug-Disease Interactions: DOMPERIDONE+PANTOPRAZOLE should be not given in patients with C. difficile induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), low magnesium (hypomagnesemia).
It is best to avoid alcohol while taking medication.
If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should use this medicine only if your doctor considers the benefit for you greater than the potential risk for your unborn child or baby.
DOMPERIDONE+PANTOPRAZOLE should be used in breastfeeding mothers only if the benefits outweigh the risks.
Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking DOMPERIDONE+PANTOPRAZOLE you should not drive or operate any machinery or vehicles.
In patients with severe liver impairment, the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use
Inform your doctor before receiving the DOMPERIDONE+PANTOPRAZOLE if you have a kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
DOMPERIDONE+PANTOPRAZOLE can be given safely to children provided; dose has been prescribed by a child specialist.
Normally a thick layer of mucous protects the stomach against its own acid secretion. But, in long run, it gets eroded by excessive stomach acid production leading to complications like GERD, peptic ulcer, and Zollinger Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe that causes heartburn. On the other hand, a peptic ulcer is a painful condition followed by the development of sores or ulcers in the stomach lining or duodenum (first part of the small intestine). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.
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