DOMPERIDONE+RANITIDINE belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.
DOMPERIDONE+RANITIDINE is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reducing gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscles. Together, DOMPERIDONE+RANITIDINE helps in treating acidity.
You are advised to take DOMPERIDONE+RANITIDINE for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dry mouth, stomach pain, constipation, headache, sleepiness, and dizziness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. DOMPERIDONE+RANITIDINE may cause sleepiness and dizziness, so drive only if you are alert. DOMPERIDONE+RANITIDINE should not be given to children as safety has not been established. Avoid consuming alcohol along with DOMPERIDONE+RANITIDINE as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.
Gastro-oesophageal reflux disease, peptic ulcers.
DOMPERIDONE+RANITIDINE belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD) and peptic ulcers. DOMPERIDONE+RANITIDINE is a combination of two drugs, namely: Ranitidine (H2 receptor antagonist) and Domperidone (a dopamine antagonist). Ranitidine works by blocking histamine H2 receptors located on the stomach lining, thereby reduces gastric acid secretion. Domperidone works by increasing the movements and contractions of stomach muscle. Together, DOMPERIDONE+RANITIDINE helps in treating acidity.
Do not take DOMPERIDONE+RANITIDINE if you are allergic to any of its contents. Inform your doctor before taking DOMPERIDONE+RANITIDINE if you have a history of gastrointestinal bleeding, porphyria, or intestinal obstruction. DOMPERIDONE+RANITIDINE may cause B12 deficiency in long-term treatment. Consult your doctor if you are pregnant or breastfeeding. DOMPERIDONE+RANITIDINE may cause sleepiness and dizziness, so drive only if you are alert. DOMPERIDONE+RANITIDINE should not be given to children as safety has not been established. Avoid consuming alcohol along with DOMPERIDONE+RANITIDINE as it could lead to increased drowsiness and can elevate the production of stomach acid.
Drug-Drug Interactions: DOMPERIDONE+RANITIDINE may have interaction with pain killers (acetaminophen, ibuprofen, aspirin, naproxen, methadone), an antidepressant (duloxetine, citalopram, escitalopram), vitamin (vitamin b12), anti-fungal (ketoconazole, fluconazole, voriconazole), antibiotics (erythromycin, clarithromycin, telithromycin, moxifloxacin, pentamidine), heart-related medicines (propranolol, procainamide, amiodarone, dronedarone, quinidine, disopyramide, dofetilide, sotalol, diltiazem, verapamil), antipsychotics (haloperidol, pimozide, sertindole), gastrointestinal drugs (cisapride, dolasetron), antihistamine (mequitazine, mizolastine), anti-malarial (halofantrine), a protease inhibitor (telaprevir), anti-cancer (toremifene, vandetanib, vincamine), anti-muscarinic (diphemanil), anti-anxiety (diazepam), anticonvulsant (phenytoin), anti-asthma (theophylline), blood thinner (warfarin), antidiabetic (glipizide).
Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, porphyria, haemodialysis, phenylketonuria, liver and kidney dysfunction.
Avoid consumption of alcohol while taking DOMPERIDONE+RANITIDINE. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Consult your doctor before taking DOMPERIDONE+RANITIDINE if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.
Consult your doctor before taking DOMPERIDONE+RANITIDINE; your doctor will decide whether DOMPERIDONE+RANITIDINE can be taken by breastfeeding mothers or not.
DOMPERIDONE+RANITIDINE may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.
Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+RANITIDINE if you have a liver impairment or any concerns regarding this.
Dose adjustment may be needed. Consult your doctor before taking DOMPERIDONE+RANITIDINE if you have kidney impairment or any concerns regarding this.
DOMPERIDONE+RANITIDINE should not be given to children as the safety and effectiveness were not established.
Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.
Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.