GABAPENTIN+NORTRIPTYLINE is a combination medicine indicated for the management of neuropathic pain. It is a chronic progressive nerve disease that causes nerve pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
GABAPENTIN+NORTRIPTYLINE contains Gabapentin and Nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline prolongs the effect of serotonin and noradrenaline and prevents movements of pain signals in the brain.
In some cases, you may experience certain common side-effects such as dizziness, sleepiness, tiredness, headache, nausea, vomiting, blurred vision, dry mouth, and tingling sensations. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
Consult your doctor if you are pregnant or breastfeeding. GABAPENTIN+NORTRIPTYLINE may cause drowsiness and dizziness, so drive only if you are alert. GABAPENTIN+NORTRIPTYLINE should not be given to children unless prescribed by the doctor. Avoid consuming alcohol along with GABAPENTIN+NORTRIPTYLINE as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Neuropathic pain
GABAPENTIN+NORTRIPTYLINE is used to treat neuropathic pain. GABAPENTIN+NORTRIPTYLINE is a combination of two drugs: Gabapentin and Nortriptyline. Gabapentin belongs to a class of drugs called anti-convulsants whereas Nortriptyline belongs to tricyclic antidepressants. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain and lowers the risk of seizures. On the other hand, Nortriptyline works by preventing the released chemical messenger in brains (serotonin and noradrenaline) from being reabsorbed back into the nerve cells (neuron) in the brain. As a result, it prolongs the effect of serotonin and noradrenaline in the brain and prevents the movement of pain signals in the brain.
Do not take GABAPENTIN+NORTRIPTYLINE if you are allergic to any of its contents. Inform your doctor before taking GABAPENTIN+NORTRIPTYLINE if you have/had heart problems or bipolar syndrome. Consult your doctor if you are pregnant or breastfeeding. GABAPENTIN+NORTRIPTYLINE may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with GABAPENTIN+NORTRIPTYLINE as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.
Drug-Drug Interactions: GABAPENTIN+NORTRIPTYLINE may interact with hypnotics (zolpidem), antidepressants (citalopram, duloxetine, escitalopram, fluoxetine, bupropion, sertraline), pain killers (codeine, hydrocodone, acetaminophen, oxycodone, tramadol, methadone), anti-histamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), anti-convulsant (clonazepam, pregabalin, topiramate), anti-thyroid (levothyroxine), anti-anxiety (diazepam, alprazolam), anti-emetic (ondansetron), anti-psychotic (quetiapine), and drugs used to treat opioid misuse (naloxone, buprenorphine).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have heart problems, pheochromocytoma (tumour of the adrenal gland), depression, seizures, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, glaucoma, diabetes, thyroid problems, suicidal tendency, haemodialysis, kidney and liver problems.
Avoid consumption of alcohol while taking GABAPENTIN+NORTRIPTYLINE as it may increase dizziness and sleepiness.
Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Consult your doctor before taking GABAPENTIN+NORTRIPTYLINE; your doctor will decide whether GABAPENTIN+NORTRIPTYLINE can be taken by breastfeeding mothers or not.
GABAPENTIN+NORTRIPTYLINE may cause drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
GABAPENTIN+NORTRIPTYLINE should not be given to children unless prescribed by the doctor.
Neuropathic pain: Neuropathic pain is a chronic progressive nerve disease caused due to damage of sensory nerves. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).