About GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE
GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE is an anticholinergic agent/acetylcholinesterase inhibitor combination that is primarily used at the end of an operation to reverse the effects of anaesthetics and muscle relaxants.
GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE is made of Glycopyrrolate and Neostigmine. Neostigmine raises acetylcholine levels by inhibiting an enzyme that breaks down acetylcholine, which is involved in nerve impulse transmission and muscle action. On the other hand, Glycopyrrolate is an anticholinergic that inhibits the negative effects of Neostigmine, such as slowed heart rate and excessive saliva production.
GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE is prescription-only medication available in the form of injection. It is administered by a qualified healthcare professional. The common side-effects of GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE are pain, itching, swelling or redness around the site of injection, constipation, dry mouth, nausea, vomiting, visual disturbance, dizziness, diarrhoea, too much saliva, dryness of skin, increased pressure on the eye, stomach cramps, the uncontrolled need of passing urine. Most of these side effects of GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Do not use GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE if you are allergic to Glycopyrrolate, Neostigmine Methylsulphate, or other substances in this drug, or if you are receiving Suxamethonium, a muscle relaxant commonly used during surgery. It is also not suggested if you have difficulties passing urine, intestinal blockage, prolonged QT interval (irregular heart rhythm), or heart problems. If you are pregnant or breastfeeding, suspect you are pregnant or plan to have a baby. Consult your doctor before driving or operating machinery since this medication may impair your ability to drive or operate machinery safely. GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE can be given to children if medically indicated; the child's age and weight determine the dose.
Uses of GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE
Used at the end of an operation to reverse the effects of anaesthetics and muscle relaxants.
Medicinal Benefits
GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE is an anticholinergic agent/acetylcholinesterase inhibitor combination that is primarily used at the end of an operation to reverse the effects of anaesthetics and muscle relaxants. GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE is composed of Glycopyrrolate and Neostigmine. Neostigmine boosts acetylcholine levels by blocking an enzyme that degrades acetylcholine, which is involved in nerve impulse transmission and muscle activity. On the other hand, Glycopyrrolate is an anticholinergic that reduces the unfavourable effects of Neostigmine, such as slow heart rate and increased saliva production.
Directions for Use
Storage
Side Effects of GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE
- Constipation
- Dry mouth
- Nausea
- Vomiting
- Visual disturbance
- Dizziness
- Diarrhoea
- Too much saliva
- Dryness of skin
- Increased pressure on the eye
- Stomach cramps
- Uncontrolled need to pass urine
In-Depth Precautions and Warning
Drug Warnings
Do not use GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE if you are allergic to Glycopyrrolate, Neostigmine Methylsulphate, or other substances in this drug, or if you are receiving Suxamethonium, a muscle relaxant commonly used during surgery. It is also not suggested if you have difficulties passing urine, intestinal blockage, prolonged QT interval (irregular heart rhythm), or heart problems. If you are pregnant or breastfeeding, suspect you are pregnant or plan to have a baby. Let the doctor know about your medical history and the ongoing therapies and medications to avoid potential negative effects or interactions. Consult your doctor before driving or operating machinery since this medication may impair your ability to drive or operate machinery safely. GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE can be given to children if medically indicated; the child's age and weight determine the dose.
Drug Interactions
Drug-Drug Interactions: GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE may interact with certain antidepressant medicines (e.g. lithium, amitriptyline, imipramine), certain medicines used for mental illness (e.g. clozapine), certain pain killers (e.g. nefopam), certain antiviral medicines (e.g. amantadine), muscle relaxant (e.g. Suxamethonium), antibiotics (e.g. gentamicin, streptomycin, colistimethate sodium), certain medicines for heart disease (e.g. procainamide, propafenone, quinidine), certain antimalarial medicines (e.g. chloroquine), and a drug used to treat a variety of ailments such as migraines, heart issues, and anxiety (e.g. propranolol).
Drug-Food Interactions: Do not consume alcohol while taking GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE as it could lead to increased dizziness and weak eyesight.
Drug-Disease Interactions: GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE may have interactions with diseases conditions, including difficulties passing urine, intestinal blockage, prolonged QT interval (irregular heart rhythm), heart problems, asthma, glaucoma, intestinal disorders, stomach ulcers, high temperature (fever), low or high blood pressure, heart disorders, overactive thyroid gland, myasthenia gravis (severe muscle weakness and fatigue), epilepsy or Parkinsonism, Pyloric stenosis (gastric outlet obstruction), and kidney or liver disorders.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consuming alcohol after taking GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE as it may cause increased dizziness.
Pregnancy
cautionGLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE contains Neostigmine which is a pregnancy category C drug. It may be unsafe for use during pregnancy since animal studies of GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE showed harmful effects on the fetus. Please inform your doctor before taking the GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE if you are pregnant or planning to conceive.
Breast Feeding
cautionThere is no substantial research yet on using GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE in breastfeeding/nursing mothers. Your doctor will weigh the benefits and potential risks before prescribing GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE.
Driving
unsafeGLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE can make you feel dizzy, have weak eyesight, and affect your driving ability. It is advised not to drive or operate machinery if you are not mentally alert and focused.
Liver
cautionIf you have pre-existing or a history of liver-related diseases, please inform your doctor before taking the GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE. Your doctor will weigh the benefits and potential risks before prescribing GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE.
Kidney
cautionIf you have pre-existing or a history of kidney-related diseases, please inform the doctor before taking the GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE. Your doctor will weigh the benefits and potential risks before prescribing GLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE.
Children
cautionGLYCOPYRROLATE+NEOSTIGMINE METHYLSULPHATE can be given to children if medically needed.
Habit Forming
Diet & Lifestyle Advise
- Maintain proper weight by following a healthy diet.
- Avoid smoking and alcohol consumption.
- Try to avoid stress by practising meditation or yoga.
- Include fruits and vegetables in your diet as they contain antioxidants.
- Limit foods with high cholesterol and saturated fats.
- Cut down on sugar, salt, and processed foods.
- Drink plenty of water.
Patients Concern
Disease/Condition Glossary
NA
