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About INSULIN ASPART

INSULIN ASPART is a rapid-acting human insulin analogue for the treatment of diabetes mellitus in both children (above two years of age) and adults. The active ingredient in INSULIN ASPART is insulin aspart. Diabetes is a medical condition where your body does not produce enough insulin to control your blood sugar level. Treatment with INSULIN ASPART helps to prevent complications from your diabetes.

When INSULIN ASPART is injected, it is extremely fast-acting and works rapidly to normalise blood sugar levels. It typically begins working after 10-20 minutes and will last for between 3 and 5 hours. Due to this short action, INSULIN ASPART should normally be taken in combination with intermediate-acting or long-acting insulin preparations. INSULIN ASPART works by ensuring rapid and consistent sugar control. INSULIN ASPART is a fast-acting form of insulin that helps lower blood sugar levels after food intake. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver.

Your doctor will advise you on how to use INSULIN ASPART. It should be administered at least 5-10 minutes before the meal or within 20 minutes after you start having a meal. The common side effects of INSULIN ASPART are hypokalaemia (low potassium), hypoglycaemia (low blood sugar level), local injection site reactions, lipodystrophy (fat deposition under the skin), rash, and pruritus (itch skin), which may occur at the injection site. Most of these side effects of INSULIN ASPART do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking INSULIN ASPART of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take INSULIN ASPART if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with INSULIN ASPART, you should take a healthy diet, exercise regularly, and maintain weight as your doctor advises. INSULIN ASPART is a cold chain medicine, so it must be stored in the refrigerator between 2-8 degrees Celsius; otherwise, its efficiency might get lost. Do not store it in the freezer of the fridge.

Uses of INSULIN ASPART

Diabetes (Type 1 diabetes mellitus, Type 2 diabetes mellitus)

Medicinal Benefits

INSULIN ASPART works by ensuring rapid and consistent sugar control. INSULIN ASPART is a fast-acting form of insulin that helps lower blood sugar levels after the intake of food. Prevents the risk of having severe complications of diabetes. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses sugar production in the liver. INSULIN ASPART helps in improving the glycaemic control, which in turn decreases the risk of progression of complications of diabetes like damage to the retina (retinopathy), damage to the kidney (nephropathy), impairment of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer and others. Besides this, INSULIN ASPART can be safely prescribed to the diabetic mother during pregnancy and lactation.

Directions for Use

INSULIN ASPART is administered 5-10 minutes before taking meal subcutaneously (SC) in the abdomen or thigh region. It can be also given intravenously (IV) with 0.9% sodium chloride infusion. However subcutaneous injection of INSULIN ASPART in the abdomen region ensures faster absorption compared to other injection sites. INSULIN ASPART is usually given once or twice daily when both rapid and prolonged effect of insulin is desired. In the initial requirement, the dose requirement is usually between 0.3 and 1.0 IU/kg per day. An injection of INSULIN ASPART should be followed within 30 minutes by a meal or snack containing sugar/glucose (carbohydrates). If you are not well trained to self-administer INSULIN ASPART, ask healthcare professional to administer it. Procedure for self-injecting insulin: • You should wash your hand first before injecting insulin. • Then roll the insulin bottle and wipe the bottle top. • Now pull the plunger of the syringe down to an appropriate number of units your doctor has prescribed. • Push the needle into the bottle and push syringe plunger down. • Now once again pull the plunger down to an appropriate number of units as prescribed by the doctor. • Pick the injection site and wipe it with an alcohol swab. Now, pinch up the skin and push the needle into the skin and then push the plunger in. • The needle should be kept under the skin for at least 6 seconds to make sure the entire dose is injected. • After injecting the insulin pull out the needle and dispose of the syringe safely. And then you can have a meal or snack.

Side Effects of INSULIN ASPART

  • Hypokalaemia (low potassium)
  • Hypoglycaemia (low blood sugar level)
  • Local injection site reactions
  • Lipodystrophy (fat deposition under the skin)
  • Rash
  • Pruritus (itchy skin)

In-Depth Precautions and Warning

Drug Warnings

INSULIN ASPART is for subcutaneous (under the skin) use only and should never be administered intravenously (IV) or in the veins. If you are changing the brand of insulin or if you need to inject your insulin by another method, it should be done under strict medical supervision. Cases of heart failure were reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first symptoms of hyperglycaemia (high blood sugar level) may include symptoms like excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. INSULIN ASPART may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma and even death. Do not take INSULIN ASPART if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs.

Drug Interactions

Drug-Drug Interactions: INSULIN ASPART may have an interaction with drugs that may increase the risk of antiarrhythmic (disopyramide), hemorrheologic agents (pentoxifylline), antidiabetic (pramlintide), bleeding disorder drugs (octreotide), antipsychotic (propoxyphene, phenothiazines), female sex hormones (progestogen, oestrogen), thyroid hormones (levothyroxine), anti-asthmatics (albuterol, epinephrine, terbutaline), an antidepressant (fluoxetine, lithium), lipid-lowering pills (reserpine, niacin, clonidine, fenofibrate, guanethidine), pain killers (aspirin), antibiotics (isoniazid), blood sugar enhancing pills (glucagon), male hormone testosterone analogue (danazol), antibiotic (pentamidine).

Drug-Food Interactions: INSULIN ASPART may interact with an ayurvedic, homoeopathy, Unani, herbal supplements or OTC items. Tell your doctor if you are using these products. Try to avoid intake of alcoholic beverages with INSULIN ASPART as it may increase or decrease your blood sugar level.

Drug-Disease Interactions: INSULIN ASPART should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • FUROSEMIDE
  • METOPROLOL
  • LEVOTHYROXINE SODIUM
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended not to consume alcohol along with INSULIN ASPART to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.

    • Safety Warning

      Pregnancy

      safe if prescribed

      INSULIN ASPART can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.

    • Safety Warning

      Breast Feeding

      safe if prescribed

      INSULIN ASPART can be given safely to nursing mothers but only under the supervision of a physician.

    • Safety Warning

      Driving

      unsafe

      Drive with caution, INSULIN ASPART usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycaemia (low blood sugar).

    • Safety Warning

      Liver

      caution

      INSULIN ASPART to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Kidney

      caution

      INSULIN ASPART to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

    • Safety Warning

      Children

      safe if prescribed

      INSULIN ASPART can be given safely to children provided; dose has to be prescribed by a child specialist.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Exercise may lower your body’s need for insulin during and sometimes after physical activity.
    • Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just before running).
    • Discuss with your doctor how to adjust your insulin regimen to accommodate exercise. 
    • Avoid eating sugar food and prefer food cooked food low in calories.
    • When travelling across more than two time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

    Special Advise

    • Your doctor may tell you to have a normal potassium level as prolonged administration causes a life-threatening condition of hypokalemia (low potassium). 
    • Always sterilize the injection site before administration of the drug.

    Patients Concern

    Disease/Condition Glossary

    Diabetes: Diabetes is a chronic or lifelong disease that prevents the body from utilizing insulin properly. Insulin is the hormone that controls sugar levels in the blood. Diabetes is a condition in which blood glucose levels are above normal. It is of two types, namely: type-1 and type-2 diabetes. Type-1 diabetes is a condition in which the pancreas produces little or no insulin. Type-2 diabetes affects the way the body processes sugar. Symptoms of diabetes include lack of energy, tiredness, frequent urination, excess thirst, dry mouth, blurry vision, constant hunger, weight loss, and itchy skin.

    FAQs

    In how much time does INSULIN ASPART shows its effect?

    INSULIN ASPART typically begins working after 10-20 minutes, and will last for between 3 and 5 hours.

    Is INSULIN ASPART safe to use in every diabetic patient?

    INSULIN ASPART can be given to treat both the condition of type 1 and type 2 diabetes mellitus. However, your doctor will decide whether INSULIN ASPART can be given to you or not depending on your present condition. INSULIN ASPART should be avoided in patients who are allergic to INSULIN ASPART or other forms of insulin, patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycaemia), and low potassium level (hypokalaemia).

    Can I drink alcohol with INSULIN ASPART?

    Try to avoid intake of alcoholic beverages with INSULIN ASPART as it may increase or decrease your blood sugar level.

    What are the common signs of hypoglycaemia?

    Cold sweat; cool pale skin; headache; rapid heartbeat; feeling sick; feeling very hungry; temporary vision changes; drowsiness; unusual tiredness and weakness; nervousness or tremor; feeling anxious; feeling confused; difficulty in concentrating are some of the common signs of the low blood sugar level in an individual.

    What to do in case I experience low blood sugar?

    If you experience low blood sugar, eat glucose tablets or another high sugar snack (e.g. sweets, biscuits, fruit juice). Measure your blood sugar if possible and rest. Always carry glucose tablets or high sugar snacks with you. You should give a call to any of your family members if you are feeling dizziness or drowsiness.

    What are the signs of allergy/rash with INSULIN ASPART?

    Local allergic reactions (pain, redness, hives, inflammation, bruising, swelling and itching) at the injection site may occur. These usually disappear after a few weeks of taking your insulin. If they do not disappear, or if they spread throughout your body, talk to your doctor immediately.

    Available Medicines for

    INSULIN ASPART