About INSULIN ASPART+INSULIN DEGLUDEC
INSULIN ASPART+INSULIN DEGLUDEC belongs to the class of medications called ‘antidiabetics’ primarily used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Diabetes Mellitus Type 1, the body does not produce enough insulin to regulate blood sugar levels. On the other hand, in Diabetes Mellitus type 2, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels), or there is resistance to insulin action. As a result, insulin is produced in large quantities, but it is not capable of operating on the body's organs.
INSULIN ASPART+INSULIN DEGLUDEC is a combination of two drugs, namely, Insulin Aspart and Insulin Degludec. Insulin aspart is a fast-acting or short-acting form of insulin that helps lower blood sugar levels after food intake. Insulin degludec is a long-acting form of insulin which begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). INSULIN ASPART+INSULIN DEGLUDEC stimulates the recovery of sugar in muscle and fat cells and suppresses sugar production in the liver. Together, INSULIN ASPART+INSULIN DEGLUDEC confirm rapid and stable sugar control by helping reuptake of sugar in fat cells and muscle, and suppressing the creation of sugar in the liver.
Take INSULIN ASPART+INSULIN DEGLUDEC as prescribed by your doctor. You are advised to take INSULIN ASPART+INSULIN DEGLUDEC for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience rash, injection site allergic reaction, weight gain, oedema (tissue swelling or fluid overload), lipodystrophy (skin thickening or pits at the injection site), hypoglycemia (low blood glucose level), itching. Most of these side effects of INSULIN ASPART+INSULIN DEGLUDEC do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking INSULIN ASPART+INSULIN DEGLUDEC of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take INSULIN ASPART+INSULIN DEGLUDEC if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with INSULIN ASPART+INSULIN DEGLUDEC, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. INSULIN ASPART+INSULIN DEGLUDEC is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might get lost. Do not store in the freezer of the fridge.
Uses of INSULIN ASPART+INSULIN DEGLUDEC
Type 1 diabetes mellitus, Type 2 diabetes mellitus
Medicinal Benefits
INSULIN ASPART+INSULIN DEGLUDEC belongs to the class of medications called ‘antidiabetics’ primarily used for the treatment of both type 1 and type 2 diabetes mellitus. INSULIN ASPART+INSULIN DEGLUDEC is a combination of two drugs, namely, Insulin Aspart and Insulin Degludec. INSULIN ASPART+INSULIN DEGLUDEC contains insulin aspart, which is a fast-acting form of insulin that helps lower blood sugar levels after food intake. INSULIN ASPART+INSULIN DEGLUDEC contains insulin degludec, which is a prolonged action form of insulin. It typically begins working after 60 minutes and is a long-acting insulin preparation (lasts for more than 24 hours). Together, they confirm rapid and stable sugar control by helping reuptake sugar in fat and muscle, and cells and suppressing the creation of sugar in the liver.
Directions for Use
Storage
Side Effects of INSULIN ASPART+INSULIN DEGLUDEC
- Rashes
- Injection site allergic reaction
- Weight gain
- Edema (swelling)
- Lipodystrophy (skin thickening or pits at the injection site)
- Hypoglycemia (low blood glucose level)
- Itching
In-Depth Precautions and Warning
Drug Warnings
INSULIN ASPART+INSULIN DEGLUDEC is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or injecting your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. INSULIN ASPART+INSULIN DEGLUDEC may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take INSULIN ASPART+INSULIN DEGLUDEC if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs.
Drug Interactions
Drug-Drug Interaction: INSULIN ASPART+INSULIN DEGLUDEC may have an interaction with pain killers (aspirin), antibiotics (isoniazid, pentamidine, ciprofloxacin), blood sugar enhancing pills (glucagon), male hormone testosterone analogue (danazol), antidiabetics (metformin), lipid-lowering pills (reserpine, niacin), blood pressure-lowering medicines (atenolol, acebutolol, metoprolol), thyroid hormones (levothyroxine), an antidepressant (fluoxetine, lithium), female sex hormones (progestogen, estrogen).
Drug-Food Interaction: INSULIN ASPART+INSULIN DEGLUDEC may interact with an ayurvedic, homeopathy, Unani, herbal supplements, or OTC items. Tell your doctor if you are using these products. Try to avoid alcoholic beverages with INSULIN ASPART+INSULIN DEGLUDEC as it may increase or decrease your blood sugar level.
Drug-Disease Interaction: INSULIN ASPART+INSULIN DEGLUDEC should not be given to patients with kidney disease, liver disease, low blood sugar/glucose level (hypoglycemia), and low potassium level (hypokalaemia).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol along with INSULIN ASPART+INSULIN DEGLUDEC to avoid unpleasant side-effects. Alcohol may either decrease or increase the blood sugar level which can be fatal.
Pregnancy
safe if prescribedINSULIN ASPART+INSULIN DEGLUDEC can be used during pregnancy. Your insulin dose may need to be changed during pregnancy and after delivery.
Breast Feeding
safe if prescribedINSULIN ASPART+INSULIN DEGLUDEC can be given safely to nursing mothers but only under the supervision of a doctor.
Driving
unsafeDrive with caution, INSULIN ASPART+INSULIN DEGLUDEC usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycemia (low blood sugar).
Liver
cautionINSULIN ASPART+INSULIN DEGLUDEC to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
cautionINSULIN ASPART+INSULIN DEGLUDEC to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
safe if prescribedINSULIN ASPART+INSULIN DEGLUDEC can be given safely to children; dose has to be prescribed under the supervision of a doctor.
Habit Forming
Diet & Lifestyle Advise
- Exercise may lower your body’s need for insulin during and for some time after the physical activity.
- Exercise may also speed up an insulin dose effect, especially if the exercise involves the injection site area (for example, the leg should not be used for injection just before running).
- Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.
- Avoid eating sugar food and prefer food cooked food low in calories.
- When travelling across more than 2 time zones, you should talk to your doctor about your insulin schedule adjustments.
Special Advise
- Your doctor may tell you to have a regular potassium level as prolonged administration causes a life-threatening hypokalemia condition (low potassium).
- Store INSULIN ASPART+INSULIN DEGLUDEC between 2-8 degree celsius temperature only. Do not store INSULIN ASPART+INSULIN DEGLUDEC in the freezer.
Patients Concern
Disease/Condition Glossary
Type 1 diabetes mellitus: In type 1 diabetes mellitus, our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.
Type 2 diabetes mellitus: In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.
