About INSULIN GLARGINE+LIXISENATIDE
INSULIN GLARGINE+LIXISENATIDE is an Antidiabetics medicine. It is recommended for adults with type 2 diabetes mellitus as a supplement to diet and exercise to improve glycemic control. Type 2 diabetes (T2DM) is a chronic (long-term) disorder that affects the body's ability to regulate blood sugar. Insulin is a hormone that regulates how the body uses glucose for energy. Type 2 diabetes occurs when the body fails to produce enough insulin or does not use it adequately.
INSULIN GLARGINE+LIXISENATIDE contains Insulin Glargine and Lixisenatide. Insulin Glargine is a long-acting insulin that provides a steady supply throughout the day, helping your body use glucose for energy. Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist, stimulating insulin release after meals and reducing sugar production by the liver, leading to lower blood sugar levels.
Sometimes, you may experience injection site reactions, such as lumps under the skin. The injection site should be rotated to prevent skin changes. You may also experience hypoglycaemia (symptoms include sweating, clammy skin, anxiety, fast heartbeat), dizziness, nausea, diarrhoea, and vomiting. Most of these side effects of INSULIN GLARGINE+LIXISENATIDE do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Try not to stop taking INSULIN GLARGINE+LIXISENATIDE of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take INSULIN GLARGINE+LIXISENATIDE if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with INSULIN GLARGINE+LIXISENATIDE, you should take a healthy diet, exercise regularly, and maintain weight as your doctor advises. INSULIN GLARGINE+LIXISENATIDE is a cold chain medicine, so it must be stored in the refrigerator between 2-8 degrees Celsius; otherwise, its efficiency might get lost. Do not store it in the fridge freezer.
Medicinal Benefits
INSULIN GLARGINE+LIXISENATIDE is a long-acting insulin that provides a steady supply throughout the day, helping your body use glucose for energy. It also helps improve glycemic control. By effectively managing blood sugar, Insulin Glargine-Lixisenatide can help reduce the risk of long-term complications associated with type 2 diabetes, such as heart disease, stroke, kidney problems, and nerve damage.
Directions for Use
Storage
Side Effects of INSULIN GLARGINE+LIXISENATIDE
- Fatigue
- Injection site reactions
- Hypoglycaemia (symptoms include sweating, clammy skin, anxiety, fast heartbeat)
- Dizziness
- Nausea
- Diarrhoea
- Vomiting
- Common cold
- Upper respiratory tract infection
- Headache
In-Depth Precautions and Warning
Drug Warnings
Before taking the INSULIN GLARGINE+LIXISENATIDE, inform your doctor about all your medical conditions (especially if you have hypoglycaemia), sensitivities (especially allergic to any component present in INSULIN GLARGINE+LIXISENATIDE), and all medications you are using to rule out any side effects. If you are pregnant or breastfeeding, do not consume INSULIN GLARGINE+LIXISENATIDE unless recommended by the doctor. INSULIN GLARGINE+LIXISENATIDE causes drowsiness and dizziness, so drive only if you are alert. INSULIN GLARGINE+LIXISENATIDE is not recommended for children as the safety and efficacy have not been established. INSULIN GLARGINE+LIXISENATIDE should be taken with caution, especially if you have a history of liver or kidney impairment. Frequent glucose monitoring and dose adjustment may be necessary for patients with liver or kidney impairment. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule.
Drug Interactions
Drug-Drug Interactions: INSULIN GLARGINE+LIXISENATIDE may interact with drugs that affect glucose metabolism, anti-cancer medications (e.g., Bexarotene), antibiotics (e.g., ciprofloxacin, gatifloxacin, levofloxacin, nalidixic acid), and Antiadrenergic drugs (e.g., clonidine, guanethidine, reserpine).
Drug-Food Interactions: Avoid drinking alcoholic beverages with INSULIN GLARGINE+LIXISENATIDE as it may raise or lower your blood sugar level.
Drug-Disease Interactions: INSULIN GLARGINE+LIXISENATIDE may interact with various disease conditions, including kidney and liver disease, low blood sugar/glucose level (hypoglycaemia), low potassium level (hypokalaemia), angioedema (swelling under the skin), gastroparesis (delayed gastric emptying), and pancreatitis (pancreas inflammation).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended not to consume alcohol along with INSULIN GLARGINE+LIXISENATIDE to avoid unpleasant side effects. Alcohol may either decrease or increase the blood sugar level, which can be fatal.
Pregnancy
cautionThe potential risk for humans is unknown. INSULIN GLARGINE+LIXISENATIDE should not be used during pregnancy. If a patient wishes to become pregnant or pregnancy occurs, treatment with INSULIN GLARGINE+LIXISENATIDE should be discontinued.
Breast Feeding
cautionThere are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Inform your doctor. Your doctor will weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Driving
cautionDrive with caution; INSULIN GLARGINE+LIXISENATIDE usually causes drowsiness and affects driving ability. Your ability to concentrate and react may be reduced if you have hypoglycaemia (low blood sugar).
Liver
cautionIf you have liver disease inform your doctor before taking INSULIN GLARGINE+LIXISENATIDE. Frequent glucose monitoring and dose adjustment may be necessary for patients with liver impairment.
Kidney
cautionINSULIN GLARGINE+LIXISENATIDE is not recommended in patients with end-stage renal disease. Frequent glucose monitoring and dose adjustment may be necessary for patients with renal impairment.
Children
cautionSafety and efficacy have not been established.
Habit Forming
Diet & Lifestyle Advise
Essential diet and lifestyle changes that can significantly benefit type 2 diabetes (T2D) patients:
Diet:
Focus on whole, unprocessed foods: Prioritize fruits, vegetables, whole grains (brown rice, quinoa, oats), and lean proteins (fish, chicken, beans). These foods provide sustained energy, regulate blood sugar, and are rich in essential nutrients.
Limit processed carbohydrates and sugary drinks: Sugary drinks, white bread, pastries, and refined carbohydrates can cause blood sugar spikes. Opt for whole-wheat versions or healthier alternatives like water and unsweetened tea/coffee.
Fiber is your friend. Fibre slows down sugar absorption, promoting healthy blood sugar levels. For a good fibre intake, include plenty of fruits, vegetables, and whole grains.
Healthy fats are essential: Unsaturated fats from sources like nuts, seeds, and olive oil can aid in satiety and improve heart health, which is crucial for diabetics.
Portion control is vital: Be mindful of portion sizes to avoid overeating and manage calorie intake.
Lifestyle:
Regular exercise is essential: Aim for at least 120-150 minutes of moderate-intensity exercise (swimming, brisk walking) or 75 minutes of vigorous exercise (running, cycling) spread throughout the week. Physical activity helps your body use insulin more effectively and lowers blood sugar levels.
Regular sleep is crucial: Aim for 7-8 hours of quality sleep each night. Poor sleep can disrupt hormones that regulate blood sugar and appetite.
Eat meals: Skipping meals can disrupt your blood sugar levels. Consistency in meal timing is essential.
Maintain a healthy weight: If you're obese or overweight, losing even a moderate amount of weight can significantly improve blood sugar control.
Stay hydrated: Drinking plenty of water helps your body function optimally and regulate blood sugar levels.
Manage stress: Chronic stress can elevate blood sugar levels. Explore relaxation techniques like yoga, meditation, or deep breathing to manage stress effectively.
Regular doctor visits: Schedule regular checkups with your doctor to monitor your blood sugar, discuss your management plan, and identify any potential complications.
Special Advise
- It is important to monitor your blood sugar levels regularly as instructed by your doctor.
- You should not change your dose or stop taking INSULIN GLARGINE+LIXISENATIDE without consulting your doctor.
- Maintain a healthy diet and exercise routine alongside your medication for optimal diabetes management.
Patients Concern
Disease/Condition Glossary
Type 2 diabetes (T2DM) is a chronic (long-term) disorder that affects the body's ability to regulate blood sugar. Insulin is a hormone that regulates how the body uses glucose for energy. Type 2 diabetes occurs when the body fails to produce enough insulin or does not use it adequately. Symptoms of diabetes include lack of energy, tiredness, frequent urination, excess thirst, dry mouth, blurry vision, constant hunger, weight loss, and itchy skin.
