Ketamine
About Ketamine
Ketamine is a prescription general anaesthetic injection used by healthcare professionals to provide anaesthesia for diagnostic and surgical procedures. It is indicated as the sole anaesthetic agent for procedures that do not require skeletal muscle relaxation, for the induction of anaesthesia before other general anaesthetics, and as a supplement to other anaesthetic agents. It is especially useful for short procedures, though it can also be used with additional doses when longer anaesthesia is required.
Because Ketamine is given by injection, it is used only in monitored clinical settings such as hospitals or surgical centres. The dose is individualised, and the medicine is administered by clinicians experienced in airway management, oxygenation, and ventilation. Before treatment, patients are generally required to fast, because Ketamine is not recommended when nil per os instructions have not been followed.
While receiving Ketamine, some people may experience nausea, vomiting, dizziness, vivid dreams, confusion, or temporary increases in blood pressure and heart rate during recovery. Emergence reactions can occur as the medicine wears off. However, you must alert your healthcare team immediately if you develop severe breathing difficulty, marked confusion, hallucinations, or a serious allergic reaction.
Do not use this medicine if a significant rise in blood pressure would be a serious hazard, or if you have a known allergy to Ketamine or any excipient. Tell your doctor before treatment if you have uncontrolled hypertension, heart disease, elevated intracranial pressure, or a psychiatric condition, because Ketamine can raise blood pressure and has been associated with emergence reactions and other psychiatric effects.
This medicine can interact with benzodiazepines, opioid analgesics, other CNS depressants, theophylline or aminophylline, and sympathomimetics or vasopressin. If you are pregnant, breastfeeding, an older adult, or have other chronic medical conditions, your healthcare team will weigh the risks and benefits carefully before giving this medicine.
Uses of Ketamine
Medicinal Benefits
Ketamine provides rapid anaesthesia for procedures that need quick onset and close monitoring. Because it acts fast after injection, it helps medical teams begin treatment or surgery without unnecessary delay and keeps the patient unconscious and pain-free during the procedure.
- Rapid onset for procedures: Starts working quickly, making it useful when anaesthesia must be established promptly.
- Useful for short procedures: Especially suitable for brief diagnostic or surgical procedures that do not require skeletal muscle relaxation.
- Can supplement other anaesthetics: May be combined with other anaesthetic agents to support balanced anaesthesia.
- Provides dissociative anaesthesia: Helps block awareness of pain and sensory input during the procedure.
Directions for Use
- Ketamine will be administered by a healthcare professional.
- Do not self-administer it.
Storage
Side Effects of Ketamine
Common Side Effects (Usually mild):
- Nausea or vomiting
- Dizziness or temporary double vision
- Vivid dreams or mild confusion during recovery
- Increased blood pressure or heart rate
- Salivation
Serious Side Effects (Call a doctor right away):
- Severe breathing difficulty or respiratory depression, especially with rapid administration or overdose
- Severe confusion, agitation, hallucinations, or emergence delirium
- Irregular heartbeat or marked changes in blood pressure
- Signs of a severe allergic reaction such as swelling of the face, lips, tongue, or throat, hives, or difficulty breathing
Medicines Containing this Salt
View AllDrug Warnings
- Check the solution before use: Do not administer the medicine if it appears discoloured or contains particles.
- Tell your team about all medicines: Benzodiazepines, opioids, other CNS depressants, theophylline/aminophylline, and sympathomimetics can affect safety during Ketamine use.
- Monitor blood pressure and heart rate: Ketamine commonly increases these values, so close monitoring is necessary during administration.
- Report mood or confusion symptoms: Emergence delirium or psychiatric symptoms can occur during recovery and should be reported promptly.
- Follow fasting and recovery instructions exactly: This reduces the risk of vomiting, aspiration, and avoidable complications.
Drug Interactions
- Benzodiazepines, opioid analgesics, and other CNS depressants: May cause profound sedation, respiratory depression, coma, or death; opioids may also prolong recovery time.
- Theophylline or aminophylline: Should not be co-administered because they may lower the seizure threshold.
- Sympathomimetics and vasopressin: May increase haemodynamic effects, so vital signs should be closely monitored.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid consumption of alcohol during treatment with Ketamine.
Pregnancy
cautionIf you are pregnant, think you may be pregnant or planning for pregnancy, inform the doctor before receiving Ketamine.
Breast Feeding
cautionIf you are breastfeeding, inform your doctor before receiving Ketamine.
Driving
unsafeKetamine may impair your thinking and reactions. Therefore, avoid driving and operating machinery for at least 24 hours after receiving Ketamine.
Liver
cautionIf you have a history of liver impairment, inform the doctor before receiving Ketamine.
Kidney
cautionIf you have a history of kidney impairment, inform the doctor before receiving Ketamine.
Children
cautionThe safety and effectiveness in children below 16 years have not been established. However, please consult your doctor for more information.
Habit Forming
Diet & Lifestyle Advise
- Follow fasting instructions carefully: Do not eat or drink for the period instructed before your procedure, because Ketamine is not recommended if nil per os guidance has not been followed.
- Arrange an adult escort: Plan for someone to take you home and stay with you after the procedure because recovery from anaesthesia may involve drowsiness or confusion.
- Rest after the procedure: Allow yourself time to recover quietly after anaesthesia and avoid strenuous activity until your clinician says it is safe.
- Avoid alcohol and sedatives: Alcohol, sleeping pills, opioids, and other CNS depressants can worsen sedation and breathing problems.
- Follow the recovery plan: Keep all post-procedure instructions, including wound care, medication advice, and follow-up appointments.
Patients Concern
Disease/Condition Glossary
Anaesthesia: Anaesthesia is the use of medications called anaesthetics to prevent pain and discomfort during surgery or other procedures. This causes a loss of sensation, feeling, and awareness.
FAQs
When given directly into a vein, Ketamine begins to work almost immediately, typically within seconds. When injected into a muscle, it takes about 3 to 4 minutes to take effect. Talk to your doctor for more details.
Most patients do not remember the medical procedure because this medication causes temporary memory loss during and shortly after its administration. Talk to your doctor if you have concerns.
No, this medication must only be administered by trained medical professionals in a hospital, clinic, or emergency setting. Talk to your doctor or pharmacist.
The main anaesthetic effect usually lasts for 10 to 15 minutes after a single intravenous dose, though complete recovery of coordination and alertness can take several hours. Talk to your doctor.
This medicine is generally reserved for situations where the medical benefits clearly outweigh the potential risks to the unborn baby. Talk to your doctor.
Fasting is essential to prevent nausea and vomiting, which can cause stomach contents to accidentally enter the lungs while you are sedated. Talk to your doctor.
You should avoid alcohol for at least 24 hours after your procedure, as it can dangerously intensify the residual sedative effects of the medicine. Talk to your doctor.
These 'emergence reactions' are recognised side effects that medical staff are trained to manage with quiet environments or supportive medications as you wake up. Talk to your doctor.
