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About LINAGLIPTIN+METFORMIN

LINAGLIPTIN+METFORMIN is a combination drug of Linagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the anti-diabetic class. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or resistance to insulin action. As a result, insulin is produced in large amounts but cannot act on the body's organs.

LINAGLIPTIN+METFORMIN contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

LINAGLIPTIN+METFORMIN should be taken with food to avoid an upset stomach. LINAGLIPTIN+METFORMIN should be taken at the same time of the day each time for the best results. Your doctor will decide what dose should be taken for better advice, which can change quickly depending on your condition. The most common side effect of LINAGLIPTIN+METFORMIN is hypoglycemia (low blood glucose levels) characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth, skin, etc. So to avoid hypoglycemia, you should not miss meals and should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

LINAGLIPTIN+METFORMIN should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking LINAGLIPTIN+METFORMIN abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy), and nerve damage (neuropathy). LINAGLIPTIN+METFORMIN should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have heart disease or are planning to get pregnant or breastfeed.

Uses of LINAGLIPTIN+METFORMIN

Type 2 Diabetes Mellitus

Medicinal Benefits

LINAGLIPTIN+METFORMIN helps your pancreas produce more insulin, make effective insulin utilization, and decrease the excess sugar that your liver makes. It helps control the rise of blood sugar levels in your body after a meal. Besides this, it does not cause weight gain in prolonged use. LINAGLIPTIN+METFORMIN plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of LINAGLIPTIN+METFORMIN

  • Low blood sugar
  • Runny nose
  • Sore throat
  • Upper lung infection
  • Diarrhoea
  • Nausea
  • Vomiting
  • Gas
  • Stomach upset
  • Indigestion,
  • General weakness
  • Headache

In-Depth Precautions and Warning

Drug Warnings

LINAGLIPTIN+METFORMIN should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking LINAGLIPTIN+METFORMIN, might develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking LINAGLIPTIN+METFORMIN, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level. LINAGLIPTIN+METFORMIN, when used with insulin, may extremely lower the blood sugar level leading to hypoglycemia condition, which can be fatal. Your doctor may adjust the dose by lowering the dose of insulin or LINAGLIPTIN+METFORMIN in this case. A prolonged intake of LINAGLIPTIN+METFORMIN may lower your thyroid-stimulating hormone (TSH); hence, TSH's annual check-up is recommended. You may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention in rare cases. Tell your doctor if you will have a diagnostic test with an injection of dye or X-ray contrast agent. The use of LINAGLIPTIN+METFORMIN should be stopped for a short time before having an X-ray procedure.

Drug Interactions

Drug-Drug Interactions: LINAGLIPTIN+METFORMIN interacts with anti-depressants (bupropion), pain killers (aspirin), antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (ranolazine, digoxin), anti-HIV drugs (dolutegravir), anti-hypertensives (amlodipine, verapamil), anti-epileptic drugs (topiramate, lamotrigine), oral contraceptives.

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with LINAGLIPTIN+METFORMIN.

Drug-Disease Interactions: People affected with heart diseases (like congestive heart failure and myocardial infarction), Vitamin B12 deficiency, and alcoholism should avoid intake of LINAGLIPTIN+METFORMIN.

Drug-Drug Interactions Checker List:

  • ASPIRIN
  • CIPROFLOXACIN
  • CIMETIDINE
  • DIGOXIN
  • AMLODIPINE
  • TOPIRAMATE
  • LAMOTRIGINE
  • BUPROPION
  • CEPHALEXIN
  • RANOLAZINE
  • DOLUTEGRAVIR
  • VERAPAMIL
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      It is best to avoid alcohol while taking LINAGLIPTIN+METFORMIN.

    • Safety Warning

      Pregnancy

      caution

      Please consult your doctor for advice before using LINAGLIPTIN+METFORMIN.

    • Safety Warning

      Breast Feeding

      caution

      Please consult your doctor for advice before using LINAGLIPTIN+METFORMIN.

    • Safety Warning

      Driving

      caution

      Drive only if you are physically stable and mentally focussed; if you experience drowsiness after taking these medications, you should not drive or operate any machinery or vehicles.

    • Safety Warning

      Liver

      caution

      If u have or had a history or evidence of any liver-related diseases, please consult the doctor before taking medicine.

    • Safety Warning

      Kidney

      caution

      If u have or had a history or evidence of any kidney-related diseases, please consult the doctor before taking medicine.

    • Safety Warning

      Children

      caution

      It is advisable to consult a doctor before using it.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
    • Eat at regular intervals. Do not take a long gap between a meal or snack.
    • Monitor your blood sugar level regularly, especially when there are lots of fluctuations.
    • Invest at least 150 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
    • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
    • Replace refined carbohydrates containing whole-grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
    • Reduce saturated fat (or hidden fats) intake in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
    • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
    • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
    • Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

    Patients Concern

    Disease/Condition Glossary

    Type 2 diabetes is a condition where the body cannot make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycemia). Type 2 diabetes symptoms include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while weight loss may be observed in rare cases. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.

    FAQs

    How does LINAGLIPTIN+METFORMIN work?

    LINAGLIPTIN+METFORMIN contains Linagliptin (DPP4 inhibitors) and Metformin (Biguanide). Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that blocks the action of DPP-4, an enzyme that destroys the hormone incretin that helps the body produce more insulin only when required. It also reduces the amount of sugar produced by the liver when not needed. Metformin functions by lowering glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

    What is type 2 diabetes, and what are its symptoms and complications?

    Type 2 diabetes is a common form of diabetes in which the blood sugar-lowering hormone called insulin produced by the body does not function properly. Thus, the blood glucose level increases, and symptoms such as frequent urination, increased thirst, and increased hunger start. Diabetes, if left untreated or not treated properly, can cause long-term complications such as nerve damage, kidney damage, eye damage, foot problems, and poses a high risk of developing heart diseases.

    How will I know that I have lactic acidosis?

    Lactic acidosis is a rare but life-threatening condition when there is too much lactic acid built up in the bloodstream. Long term intake of LINAGLIPTIN+METFORMIN may lead to lactic acidosis when cells get deprived of oxygen levels. Lactic acidosis symptoms include a burning sensation of muscle, muscle ache, fast breathing, nausea, and stomach pain. Immediately contact the doctor about this complication.

    Can I take alcohol with LINAGLIPTIN+METFORMIN?

    Do not take excessive alcohol while taking LINAGLIPTIN+METFORMIN, as this may increase the risk of a life-threatening condition called lactic acidosis (too much lactic acid in the body).

    Is LINAGLIPTIN+METFORMIN also prescribed for the treatment of type 1 diabetes?

    No, LINAGLIPTIN+METFORMIN is only prescribed to treat type 2 diabetes, also called 'non-insulin-dependent diabetes.'

    Why should LINAGLIPTIN+METFORMIN be given with caution in older adults?

    LINAGLIPTIN+METFORMIN should be given with caution in older adults as they are at an increased risk of hypoglycemia. Consult your doctor; dose adjustment may be required, and take LINAGLIPTIN+METFORMIN in dose as prescribed by your doctor.

    What should I do if my blood sugar level suddenly goes down?

    If you feel that your blood sugar level is decreasing and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.

    Available Medicines for

    LINAGLIPTIN+METFORMIN