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Lurasidone

About Lurasidone

Lurasidone is a prescription medicine used to treat schizophrenia in adults and teenagers, as well as depressive episodes associated with bipolar disorder. It belongs to a class of medications called atypical antipsychotics, which work to help restore the balance of natural chemical signals in the brain. This medication is designed to improve your thinking, mood, and daily behaviours.

For this medicine to work effectively, you need to take it consistently every single day at the same time. You must always take Lurasidone with food, specifically, a meal or snack containing at least 350 calories to ensure your body absorbs it properly. Incorporating a structured daily routine, regular sleep schedules, and stress-reduction techniques can greatly support the benefits of your treatment.

While taking this medicine, you may experience some mild side effects like drowsiness or mild nausea. However, you should contact your doctor immediately if you experience more serious issues, such as uncontrollable muscle movements, severe muscle stiffness, or extreme restlessness.

Do not take this if you have had a severe allergic reaction to it in the past. Talk to your doctor before starting Lurasidone if you have a history of liver damage, kidney problems, heart disease, high cholesterol, or diabetes. It is also important to tell your doctor if you have a history of seizures or Parkinson's disease.

Certain medicines can interfere with how this medicine works, so share your full prescription list with your healthcare provider. Avoid drinking alcohol while on this medication, as it can dangerously increase sleepiness and dizziness. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor to ensure this treatment is safe for your specific situation.

Uses of Lurasidone

Lurasidone used in the treatment of schizophrenia and bipolar disorder. The detailed uses of Lurasidone are as follows: • Treats Schizophrenia: Lurasidone helps to manage symptoms like hallucinations, delusions, confused thinking, and lack of motivation in people with schizophrenia. • Manages bipolar depression: Lurasidone is also used to treat depression that occurs in people with bipolar disorder (a condition with mood swings between high and low). • Improves mood and daily functioning: Lurasidone helps to improve mood, thinking, and behavior, making it easier for individuals to manage daily life and relationships.

Medicinal Benefits

Lurasidone helps manage symptoms of certain mental health conditions by helping restore the balance of brain chemicals involved in mood, thinking, and behaviour. Key benefits include:

  • Helps Stabilise Mood and Thinking: By regulating brain activity, Lurasidone helps reduce symptoms such as mood changes, disturbed thinking, and behavioural disturbances, supporting improved daily functioning.
  • Provides Relief from Bipolar Depression: In people with bipolar disorder, Lurasidone helps reduce symptoms of depressive episodes, such as persistent sadness, low energy, and loss of interest in daily activities.
  • Supports Overall Quality of Life: By improving mood stability and reducing symptoms, Lurasidone helps individuals manage daily responsibilities, maintain social relationships, and participate more comfortably in everyday activities.

Directions for Use

  • Lurasidone can be taken with or without food as advised by a doctor.
  • It is advised to take Lurasidone exactly as prescribed by your doctor, following the recommended dosage and duration for your specific medical condition to achieve optimal results
  • Swallow Lurasidone as a whole with a glass of water.
  • Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lurasidone

Common Side Effects (Usually mild):

  • Drowsiness, sleepiness, or feeling tired
  • Nausea, vomiting, or mild stomach upset
  • Restlessness or a strong urge to keep moving
  • Stiffness, muscle shaking, or difficulty moving smoothly

Serious Side Effects (Call a doctor right away):

  • Uncontrolled movements in your face, tongue, jaw, or limbs
  • High fever, stiff muscles, rapid heartbeat, sweating, and confusion
  • Sudden dizziness or lightheadedness when standing up quickly
  • Signs of a severe allergic reaction, such as swelling of the face, tongue, or throat, hives, and trouble breathing

Drug Warnings

  • Avoid alcohol: Do not drink alcohol while taking Lurasidone, as it may increase drowsiness, dizziness, and other nervous system side effects.
  • Be cautious with activities requiring alertness: Do not drive, operate machinery, or perform tasks requiring concentration until you know how Lurasidone affects you, as it may cause sleepiness, dizziness, or impaired alertness.
  • Stand up slowly: Rise gradually from a sitting or lying position to reduce the risk of dizziness, light-headedness, or falls, especially when you first start treatment or after a dose increase.
  • Do not stop treatment abruptly: Never stop taking Lurasidone without consulting your doctor. Stopping the medicine suddenly may worsen your condition or cause withdrawal symptoms. Your doctor will advise you on how to reduce the dose gradually if treatment needs to be discontinued.
  • Inform healthcare providers: Tell your doctor, dentist, or other healthcare professionals that you are taking Lurasidone before any surgery, dental procedure, or before starting any new prescription, over-the-counter, or herbal medicines.

Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Strong CYP3A4 inhibitors: Medicines like ketoconazole (an antifungal) or clarithromycin (an antibiotic) can significantly increase the levels of Lurasidone in your blood, raising the risk of severe side effects.
  • Strong CYP3A4 inducers: Medicines like rifampin (an antibiotic) or carbamazepine (a seizure medication) can drastically lower the amount of Lurasidone in your body, making it less effective.
  • Central nervous system depressants: Combining this medicine with sleep aids, anxiety medications, or opioid pain relievers can lead to severe drowsiness and slow breathing.

Drug-Drug Interactions Checker List:

  • LEVODOPA
  • ERGOTAMINE
  • TERFENADINE
  • ASTEMIZOLE
  • CISAPRIDE
  • PIMOZIDE
  • QUINIDINE
  • BEPRIDIL
  • MOCLOBEMIDE
  • TRANYLCYPROMINE
  • CITALOPRAM
  • ESCITALOPRAM
  • FLUOXETINE
  • FLUVOXAMINE
  • PAROXETINE
  • SERTRALINE
  • DULOXETINE
  • VENLAFAXINE
  • AMITRIPTYLINE
  • DOXEPIN
  • TRIMIPRAMINE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consuming alcohol while on treatment with Lurasidone as it may increase the risk of side effects.

    • Safety Warning

      Pregnancy

      caution

      Lurasidone is not recommended for use in pregnancy. Hence, if you are pregnant, inform your doctor before taking Lurasidone. Your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      It is not known if Lurasidone passes into the breastmilk. If you are breastfeeding, consult your doctor before taking Lurasidone, your doctor will prescribe this medicine if the benefits outweigh the risks.

    • Safety Warning

      Driving

      caution

      Lurasidone may cause dizziness. So, it is not recommended to drive or operate heavy machinery after taking Lurasidone.

    • Safety Warning

      Liver

      caution

      Lurasidone should be used with caution in patients with liver disease. If you have liver disease, inform your doctor before taking Lurasidone. Your doctor may adjust the dose based on your condition.

    • Safety Warning

      Kidney

      caution

      Lurasidone should be used with caution in patients with kidney disease. If you have kidney disease, inform your doctor before taking Lurasidone. Your doctor may adjust the dose based on your condition.

    • Safety Warning

      Children

      unsafe

      Lurasidone is not recommended for use in children under 13 years.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • The 350-calorie rule: Plan your doses around a substantial meal, such as breakfast or dinner. A light snack like a piece of fruit is not enough; aim for a balanced meal containing proteins, fats, and carbohydrates to ensure proper medication absorption.
    • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine. Grapefruit contains compounds that can increase the amount of the medication in your body, raising your risk of side effects.
    • Stay hydrated: This medication can interfere with your body's ability to regulate its temperature. Drink plenty of water and be careful during vigorous exercise or in hot weather to avoid overheating.
    • Monitor your weight and blood sugar: Antipsychotic medicines can sometimes cause changes in your weight, cholesterol, or blood sugar levels. Keep a regular log of your weight and focus on a diet rich in vegetables, lean proteins, and whole grains.

    Special Advise

    Lurasidone may increase blood sugar levels even if you do not have diabetes, especially in patients with schizophrenia. So, it is recommended to immediately inform your doctor if you have symptoms such as increased thirst, frequent urination, fatigue or increased appetite.

    Patients Concern

    Disease/Condition Glossary

    Schizophrenia: It is a condition in which the person may see, hear or feel things that are not there, believe things that are not true, or feel unusually suspicious or confused. Symptoms include hallucinations, delusions, thought disorders, movement disorders, disorganized thinking, loss of interest, lack of emotions, etc.

    Bipolar disorder: It is a serious brain disorder in which a person goes through unusual mood changes (mood swings), and frequent changes in his/her behaviour and thinking.

    FAQs

    It may take several weeks before you notice the full benefits of Lurasidone, although some symptoms may begin to improve within the first week or two. It is crucial to keep taking the medicine daily even if you do not feel immediate changes. Talk to your doctor if you have concerns about your progress.

    Take the missed dose with food as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you frequently forget your doses.

    Some people may experience weight gain while taking Lurasidone, though it generally has a lower risk of causing significant weight gain compared to some other medicines in its class. Regular exercise and a balanced diet can help manage your weight. Talk to your doctor or pharmacist for personalised lifestyle advice.

    You should avoid alcohol while taking Lurasidone. Alcohol can increase the medicine's sedative effects, making you more drowsy, dizzy, or less alert, which increases the risk of falls and accidents. You should also avoid grapefruit or grapefruit juice because it may affect how the medicine is processed in your body. Talk to your doctor if you have questions about food or drink interactions.

    Yes, Lurasidone can make it harder for your body to cool down, increasing the risk of dehydration or heatstroke. Avoid staying in hot environments for too long, drink plenty of fluids, and wear light clothing during hot weather. Talk to your doctor if you experience signs of overheating like extreme thirst or dizziness.

    You must never stop taking Lurasidone suddenly without consulting your healthcare provider. Stopping this medicine abruptly can cause your symptoms to return or worsen. If you need to stop, your doctor will guide you on gradually decreasing your dose to safely discontinue the medication. Talk to your doctor before making any changes.

    Lurasidone should only be used during pregnancy if your doctor determines that the potential benefits outweigh the risks. Taking this medicine during the third trimester may cause withdrawal symptoms or movement disorders (extrapyramidal symptoms) in newborn babies, including muscle stiffness, tremors, sleepiness, breathing difficulties, or feeding problems. If you are pregnant, planning a pregnancy, or become pregnant during treatment, consult your doctor promptly.

    No. You must take Lurasidone with food containing at least 350 calories, as taking it without enough food can significantly reduce how much of the medicine your body absorbs. Swallow the tablet whole with a glass of water and do not crush or chew it. If you have difficulty planning your doses around meals, speak with your doctor or pharmacist.

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