METFORMIN+TENELIGLIPTIN belongs to the group of medications called ‘antidiabetic agents’ used to treat Type 2 diabetes mellitus. This medication improves glycaemic control in diabetic patients in those patients who do not react well to Metformin alone. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal. It occurs when the body does not produce enough insulin (metabolizes glucose), or if produced, it cannot function properly in the body.
METFORMIN+TENELIGLIPTIN is a combination of two medicines, namely: Metformin and Teneligliptin. Metformin comes into the category of medications known as 'biguanides', and it acts by decreasing liver glucose production and intestinal glucose uptake. On the other side, Teneligliptin works by stopping the action of the dipeptidyl Peptidase 4 enzyme, which in turn increases the insulin levels in the body and reduces the glucagon levels. All of these actions reduce sugar levels in the body.
You should take this medicine as prescribed by your doctor. You may experience side-effects of such as nausea (feeling sick), vomiting (falling sick), diarrhoea, headache, stomach ache, respiratory infection, weight gain, sweating, palpitations, and vision problems. Some patients experience decline in blood sugar levels lower than normal (hypoglycemia), resulting in sweating, dizziness, headache, confusion, feeling hungry, temporary changes in vision, uneasiness, irritability, and weakness. In such cases, seek medical attention immediately.
Do not take METFORMIN+TENELIGLIPTIN if you are allergic to any of its contents. Do not use this medicine if you have heart failure, bladder cancer, or diabetic ketoacidosis (a complication of diabetes). METFORMIN+TENELIGLIPTIN may cause ‘lactic acidosis’ (accumulation of lactic acid in the blood), which requires immediate medical attention. The risk increases if you are previously diagnosed with kidney or liver diseases. Do not consume alcohol (risk of lactic acidosis) or fast for prolonged periods (risk of hypoglycemia). Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
Type 2 Diabetes Mellitus.
METFORMIN+TENELIGLIPTIN is suggested for the management of type 2 diabetes to be followed with the right diet and exercise. METFORMIN+TENELIGLIPTIN is given in combination in patients whose diabetes is not effectively controlled with Metformin alone. This medicine makes the body more responsive to insulin and helps the body to a normal state. Metformin tablets are especially advised to release the drug at a slow rate in the body from time to time.
METFORMIN+TENELIGLIPTIN should be used with caution in patients with heart diseases as it increases the risk of heart failure. METFORMIN+TENELIGLIPTIN may cause ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems as their normal functioning is required to eliminate excess lactic acid from the body. Do not consume excess alcohol as it increases the risk of lactic acidosis. METFORMIN+TENELIGLIPTIN may lower vitamin B12 levels, so it is recommended to take blood tests regularly to identify any vitamin deficiencies.
Drug-Drug Interactions: METFORMIN+TENELIGLIPTIN may have an interaction with medicines used to treat bacterial infections (rifampicin, tetracycline, Clarithromycin), a medicine used to treat fungal infections (fluconazole), other oral antidiabetics, medicines used to treat gout (probenecid).
Drug-Food interactions: Intake of excess alcohol may increase the chance of a life-threatening condition known as lactic acidosis.
Drug-Disease Interactions: METFORMIN+TENELIGLIPTIN should be avoided in patients with heart diseases (congestive heart failure and myocardial infarction), vitamin B12 deficiency, alcoholism, type I diabetes, bladder cancer, oedema (fluid retention), liver disease, premenopausal anovulation, obesity (weight gain), anaemia should avoid intake of METFORMIN+TENELIGLIPTIN.
Alcohol may increase the risk of side-effects and worsen the condition.
METFORMIN+TENELIGLIPTIN is a category C drug and may cause harmful effects to the unborn baby. So, it is used only when the benefits of this medicine outweigh the risks.
METFORMIN+TENELIGLIPTIN should not be used in breastfeeding mothers as it may get secreted in the breast milk and cause unwanted effects in the nursing babies.
METFORMIN+TENELIGLIPTIN may cause vision problems. So, do not drive or operate heavy machinery if you have any problems with your vision while using METFORMIN+TENELIGLIPTIN.
METFORMIN+TENELIGLIPTIN should be taken with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.
METFORMIN+TENELIGLIPTIN should be taken with caution, especially if you have a history of kidney diseases. The dose may have to be adjusted by your doctor.
METFORMIN+TENELIGLIPTIN is not recommended for use in children below 18 years of age.
Type 2 diabetes mellitus: It is a chronic condition in which blood glucose levels are elevated in the body. Insulin is responsible for the utilization of glucose by the cells. In type 2 diabetes, the body cells do not respond to insulin, or in later stages, your body may not produce enough insulin. Symptoms include excessive thirst, excessive hunger, fatigue, increased appetite and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.