About MITOXANTRONE
MITOXANTRONE belongs to a group of medicines known as anthracenedioness. MITOXANTRONE treats leukaemia and prostate cancer. It may also be used to treat multiple sclerosis (MS). Leukaemia is a type of cancer that develops in blood-forming tissue. Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen. Multiple sclerosis is a condition that affects the brain and spinal cord, resulting in symptoms such as problems with sensation, balance, vision, pain, impaired coordination, and fatigue.
MITOXANTRONE contains Mitoxantrone. In Cancer treatment, MITOXANTRONE works by slowing down the growth of cancer cells. In multiple sclerosis (MS) treatment, MITOXANTRONE works by slowing down an overactive immune system, which prevents or delays worsening symptoms. It also decreases the number of flare-ups.
MITOXANTRONE should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as diarrhoea, hair loss, headache, irregular menstrual cycles or spotting, nausea, pain, redness, or swelling with sores inside the mouth or throat. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.
MITOXANTRONE may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant. Talk to your care team about reliable forms of contraception. A negative pregnancy test is required before starting this medication. Do not breastfeed while taking this medication. Men using this MITOXANTRONE must use effective birth control whenever they have sex during their treatment and for a certain period after their final dose.
Uses of MITOXANTRONE
Leukaemia, Prostate cancer and multiple sclerosis (MS)
Medicinal Benefits
MITOXANTRONE contains Mitoxantrone, which belongs to a group of medicines known as anthracenedioness. MITOXANTRONE is used to treat leukaemia and prostate cancer. It may also be useful in treating multiple sclerosis (MS). MITOXANTRONE helps in cancer treatment by decreasing the proliferation of cancer cells. MITOXANTRONE acts in treating multiple sclerosis (MS) by calming down an overactive immune system, which avoids or delays the worsening of symptoms. It also reduces the frequency of flare-ups.
Directions for Use
Storage
Side Effects of MITOXANTRONE
- Nausea
- Vomiting
- increased infections
- bruising and bleeding easily
- Anemia
- Lower-than-normal levels of neutrophils
- Low white blood cell count
- Diarrhea
- Tiredness
- Nausea
- Loss of appetite
- Vomiting
- Constipation
- Abnormal weakness
- Abdominal pain
- Back pain
- Peripheral neuropathy
- Fever
- Shortness of breath
- Cough
- Pain in joint
- Hair loss
In-Depth Precautions and Warning
Drug Warnings
Before taking the MITOXANTRONE, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. White blood cells protect the body from infection. This medication may cause a decrease in the amount of white blood cells in your blood. You are more prone to catching an infection if your white blood cell count is low. When the quantity of white blood cells is too low, a condition can be deadly. It is critical to treat any infection as quickly as possible. Make an immediate call to the hospital. Use a condom or effective birth control method if you are having sex with pregnant women or women who can become pregnant. Mitoxantrone injection can produce severe or life-threatening allergic reactions, especially during the first induction course. If it happens, kindly inform your doctor immediately; your doctor may stop the second induction course, which should be withheld until the toxicity resolves. Mitoxantrone injection may cause cardiac damage at any moment during treatment or months to years after treatment has discontinued. This heart damage can be severe and fatal, and it can occur even in people who are not at risk for heart disease. Before starting mitoxantrone medication, your doctor will evaluate you and do certain tests to see how well your heart is operating and if you exhibit any indicators of cardiac problems.
Drug Interactions
Drug-Drug Interactions: MITOXANTRONE interacts with medicines used to treat a wide variety of inflammatory conditions (e.g. adalimumab), immunomodulatory medication (e.g. baricitinib, fingolimod), Vaccinations (BCG Vaccine, Dengue vaccine, Smallpox vaccine), and psychiatric medication (e.g. clozapine),
Drug-Food Interactions: Do not drink Alcoholic beverages while treated with MITOXANTRONE. It can affect the way the medicine works.
Drug-Disease Interactions: Inform your doctor before taking the MITOXANTRONE if you suffer from infections (bacterial/fungal/protozoal/viral), heart disease, liver dysfunctions, fever, bone marrow depression/low blood counts, and bleeding disorders, as it requires close monitoring.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid alcohol consumption while on treatment with MITOXANTRONE.
Pregnancy
unsafeMITOXANTRONE should not be used during pregnancy as it may cause fetal harm. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.
Breast Feeding
unsafeMITOXANTRONE may not be safe for use in breastfeeding. Your doctor may suggest you stop breastfeeding during the treatment and until a certain period after the last dose of MITOXANTRONE.
Driving
cautionMITOXANTRONE may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.
Liver
cautionMITOXANTRONE should not be used to treat patients with multiple sclerosis who have liver disease. Other patients with liver disease should be treated with caution, and their dosage may need to be adjusted.
Kidney
cautionLimited information was available about using MITOXANTRONE in patients with kidney disease. Inform your doctor before receiving the MITOXANTRONE if you have a history of kidney diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.
Children
cautionThe safety and effectiveness of MITOXANTRONE in pediatric patients have not been established.
Habit Forming
Diet & Lifestyle Advise
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Performing yoga may also help in improving both physical and mental health.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
- Get optimal sleep; rest well.
- Avoid smoking and alcohol consumption.
- Avoid fast, fried, processed meats, refined carbs and added sugars.
Special Advise
- MITOXANTRONE should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking MITOXANTRONE.
- Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to the Mitoxantrone injection.
- Do not donate sperm during treatment with MITOXANTRONE for a certain period after your last dose.
Patients Concern
Disease/Condition Glossary
Leukemia: Leukemia is a type of cancer that develops in blood-forming tissue. The condition is distinguished by uncontrolled proliferation of blood cells, most commonly white blood cells in the bone marrow. White blood cells are an important part of the body's immunological response. Normal blood and marrow cells are pushed out and replaced by leukaemia cells.
Prostate cancer: Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen. Inability to urinate easily, pain, numbness, or sexual issues are among the symptoms. For men, it is the most typical type of cancer. Although the exact cause of prostate cancer is unknown, it may be brought on by family history, chemical exposure, or both. Prostate cancer risk factors include a family history of the disease, advanced age, obesity, and genetic changes.
Multiple Sclerosis: Multiple sclerosis is a condition that affects the brain and spinal cord, resulting in symptoms such as problems with sensation, balance, vision, pain, impaired coordination, and fatigue. The immune system attacks the protective covering of the nerves (myelin) and causes disrupted communication between the brain and body due to nerve damage.
