Do not take NABUMETONE if you are allergic to any of its components, aspirin or NSAIDS, or if you have/had stomach/peptic ulcer, perforation, or bleeding, peptic disease, severe heart failure, liver cirrhosis, kidney failure, or if you are in the last three months of pregnancy or breastfeeding. Inform the doctor if you have/had asthma, stomach problems (Crohn’s disease or ulcerative colitis), liver, kidney or heart problems, high blood pressure, stroke, oedema, autoimmune diseases, diabetes, high cholesterol, infections, are in the first six months of pregnancy, smoker, or if you are above 65 years of age. NABUMETONE is not recommended for children. Stop taking NABUMETONE and consult a doctor immediately if you experience difficulty breathing, face or throat swelling, severe rash that may blister, chest pain or sudden numbness and confusion, blood in stools (black/tarry stools), or blood in vomit (dark particles that look like coffee granules). Do not take NABUMETONE if you have recently had a heart attack unless prescribed by your doctor. Seek emergency medical help immediately if you experience symptoms such as chest pain, weakness in one part or side of the body, shortness of breath, or slurred speech. NABUMETONE may cause gastrointestinal events, including bleeding, ulceration, and perforation of the stomach or intestines. If you experience any of the following symptoms, stop taking NABUMETONE and consult your doctor: stomach pain, vomit that is bloody or looks like coffee grounds,  heartburn, blood in the stool, or black and tarry stools.

Drug-Drug Interactions: Inform the doctor if you are taking antidepressants (duloxetine, escitalopram, fluoxetine, sertraline), diuretics (hydrochlorothiazide), anti-hypertensive (lisinopril), corticosteroid (prednisone), anti-diabetic (metformin)

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform the doctor if you have asthma, fluid retention, gastrointestinal toxicity, kidney problems, thrombosis, liver disease, anaemia, heart problems, high blood pressure, high potassium levels or platelet aggregation inhibition.

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20 minutes regularly.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

• Your doctor may advise regular tests to monitor liver and kidney function.
• If you are due to undergo CABG surgery (coronary artery bypass graft, a type of heart surgery), you should not take NABUMETONE right before or right after the surgery.