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About PREGABALIN+AMITRIPTYLINE

PREGABALIN+AMITRIPTYLINE is a combination medicine indicated for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation.

PREGABALIN+AMITRIPTYLINE is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, PREGABALIN+AMITRIPTYLINE helps to treat neuropathic pain. 

You are advised to take PREGABALIN+AMITRIPTYLINE for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as weight gain, dry mouth, blurred vision, dizziness, tiredness, nausea, vomiting, diarrhoea, and constipation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. PREGABALIN+AMITRIPTYLINE may cause drowsiness and dizziness, so drive only if you are alert. PREGABALIN+AMITRIPTYLINE should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with PREGABALIN+AMITRIPTYLINE as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of PREGABALIN+AMITRIPTYLINE

Neuropathic pain

Medicinal Benefits

PREGABALIN+AMITRIPTYLINE is a combination of two drugs: Pregabalin (anti-convulsant), and Amitriptyline (antidepressant). Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, PREGABALIN+AMITRIPTYLINE helps to treat neuropathic pain. 

Directions for Use

Take PREGABALIN+AMITRIPTYLINE with or without food. Swallow PREGABALIN+AMITRIPTYLINE as a whole with a glass of water; do not chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of PREGABALIN+AMITRIPTYLINE

  • Weight gain
  • Dry mouth
  • Blurred vision
  • Dizziness
  • Tiredness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation

In-Depth Precautions and Warning

Drug Warnings

Do not take PREGABALIN+AMITRIPTYLINE if you are allergic to any of its contents; if you have taken MAO inhibitors in the last 14days. Inform your doctor before taking PREGABALIN+AMITRIPTYLINE if you have/had heart problems, bipolar syndrome, severe liver disease or porphyria. Consult your doctor if you are pregnant or breastfeeding. PREGABALIN+AMITRIPTYLINE may cause drowsiness and dizziness, so drive only if you are alert. PREGABALIN+AMITRIPTYLINE should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with PREGABALIN+AMITRIPTYLINE as it could lead to increased drowsiness and sleepiness.

Drug Interactions

Drug-Drug Interactions: PREGABALIN+AMITRIPTYLINE may interact with antidepressants (duloxetine, sertraline, escitalopram), pain killers (fentanyl, hydrocodone, morphine, oxycodone, acetaminophen), anti-convulsant (topiramate), anti-anxiety (alprazolam), sedative-hypnotics (zolpidem), antihistamine (diphenhydramine, cetirizine), muscle relaxant (cyclobenzaprine), thyroid hormone (levothyroxine).

Drug-Food Interactions: Avoid alcohol consumption while taking PREGABALIN+AMITRIPTYLINE as it might cause increased dizziness and sleepiness.

Drug-Disease Interactions: Inform your doctor if you have suicidal tendency, angioedema, creatine kinase elevations, heart problems, depression, fits, pheochromocytoma (tumour of the adrenal gland), bone marrow suppression, tardive dyskinesia (involuntary facial movements), glaucoma, schizophrenia, bipolar disorder, thyroid problems, urinary retention, kidney or liver problems.

Drug-Drug Interactions Checker List:

  • DULOXETINE
  • SERTRALINE
  • ESCITALOPRAM
  • FENTANYL
  • HYDROCODONE
  • ACETAMINOPHEN
  • MORPHINE
  • OXYCODONE
  • TOPIRAMATE
  • ALPRAZOLAM
  • ZOLPIDEM
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • CYCLOBENZAPRINE
  • LEVOTHYROXINE
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid consumption of alcohol while taking PREGABALIN+AMITRIPTYLINE as it may increase drowsiness and sleepiness.

    • Safety Warning

      Pregnancy

      caution

      Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

    • Safety Warning

      Breast Feeding

      caution

      Consult your doctor before taking PREGABALIN+AMITRIPTYLINE; your doctor will decide whether PREGABALIN+AMITRIPTYLINE can be taken by breastfeeding mothers or not.

    • Safety Warning

      Driving

      unsafe

      PREGABALIN+AMITRIPTYLINE may cause drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

    • Safety Warning

      Kidney

      caution

      Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

    • Safety Warning

      Children

      caution

      PREGABALIN+AMITRIPTYLINE should not be given to children as the safety and efficacy have not been established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Include food rich in vitamin B and D in your diet.
    • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
    • Exercising regularly helps in improving overall health and combating pain.
    • Rest well, and get plenty of sleep.
    • Try taking a warm bath, as it can be soothing.
    • Avoid smoking and alcohol consumption.
    • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
    • Acupuncture can be helpful by stimulating pressure points.
    • Using essential oils for massages can help increase circulation.

    Patients Concern

    Disease/Condition Glossary

    Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury; the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful).

    FAQs

    How does PREGABALIN+AMITRIPTYLINE work?

    PREGABALIN+AMITRIPTYLINE contains Pregabalin and Amitriptyline. Pregabalin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Amitriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Together, PREGABALIN+AMITRIPTYLINE helps to treat neuropathic pain.

    Does PREGABALIN+AMITRIPTYLINE cause weight gain?

    PREGABALIN+AMITRIPTYLINE may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

    How to cope with dry mouth?

    Dry mouth could be a side-effect of PREGABALIN+AMITRIPTYLINE. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

    Can I stop taking PREGABALIN+AMITRIPTYLINE if I feel well?

    To treat your condition effectually, continue taking PREGABALIN+AMITRIPTYLINE for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking PREGABALIN+AMITRIPTYLINE; your doctor will reduce the dose gradually.

    Is PREGABALIN+AMITRIPTYLINE used to treat diabetic neuropathy?

    PREGABALIN+AMITRIPTYLINE is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.

    Does PREGABALIN+AMITRIPTYLINE cause sexual disturbances?

    PREGABALIN+AMITRIPTYLINE may cause sexual disturbances such as decreased sex drive and problems with erection. Consult your doctor if you have any concerns regarding this.

    Available Medicines for

    PREGABALIN+AMITRIPTYLINE