PROBENECID belongs to a class of medication called uricosuric, primarily used to decrease blood uric acid levels in the body. It is used to treat Gout and Gouty arthritis (increased uric acid leading to inflammation). Gout is a painful type of inflammatory arthritis. It normally affects one joint at a time (often the big toe joint). This condition is caused by high uric acid levels.
PROBENECID contains probenecid, which works by blocking urate tubular reabsorption, lowering serum urate levels. This prevents uric acid synthesis within the body without interfering with the necessary mechanisms of cells and the body.
PROBENECID should be taken as prescribed by your doctor. The dose of this medicine will be decided by your doctor, depending upon your medical condition. This medicine may cause certain common side effects such as upset stomach, headache, diarrhea, skin rash, loss of appetite, drowsiness, nausea and vomiting. Most of these side effects of PROBENECID are temporary, do not require medical attention, and gradually resolve over time. However, if the side effects persist or worsen, reach out to your doctor.
Avoid taking PROBENECID if you are allergic to any of its ingredients. Before taking this medicine, let your doctor know about all your medical and medication history, including herbal and vitamin supplements, to avoid possible interactions. Inform your doctor if you are pregnant or planning pregnancy or breastfeeding before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. Inform your doctor if you have/had any history of kidney stones, a kidney disorder, or a blood disorder. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you have unexplained weight loss, please see your doctor right once.
Gout (increased uric acid in joints)
PROBENECID contains a uricosuric medication which is primarily used to decrease blood uric acid levels in the body. PROBENECID contains probenecid, primarily used to decrease blood uric acid levels in the body. It works by inhibiting the tubular reabsorption of urate, thus decreasing serum urate levels. This stops uric acid formation inside the body without affecting the essential mechanism of cells and the body.
Do not take PROBENECID if you are allergic to any of its ingredients. Let your doctor know about all your medical and medication history, including herbal and vitamin supplements, to avoid any undesirable side effects. Inform your doctor if you are pregnant or planning to get pregnant, or are breastfeeding before taking this medicine. Drink at least 2-3 litres of water so that you stay hydrated. Inform your doctor if you have/had any history of kidney stones, a kidney disorder, or a blood disorder. For people who have kidney disease or renal dysfunction, dose adjustment is required. If you lose unexplained weight, please visit your doctor immediately. PROBENECID is not recommended for use in children below two years of age. It is advised not to drive vehicles or operate machines as PROBENECID can make you drowsy.
Drug-Drug Interactions: PROBENECID is known to interact with a blood thinner (aspirin), antihypertensive medicines (captopril), anti-bacterial medicines (ampicillin and amoxicillin), medicines used to thin the blood (dicoumarol, warfarin), anti-diabetic medicines (chlorpropamide), anti-epilepsy medicines (phenytoin, carbamazepine), medicines used for chemotherapy (azathioprine, mercaptopurine, cyclophosphamide), immune suppressant medicine (cyclosporine), asthma medicines (theophylline), diuretics
Drug-Food Interactions: PROBENECID is known to interact with alcohol.
Drug-Disease Interactions: PROBENECID is known to interact in kidney or liver problems, hypertension (high blood pressure), heart problem, thyroid problems, chemotherapy.
Avoid consumption of alcohol while taking PROBENECID as consuming alcohol may worsen your condition.
If you are pregnant or planning pregnancy, inform your doctor before taking PROBENECID. Your doctor may prescribe this medicine if the benefits outweigh the risks.
It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before taking PROBENECID.
PROBENECID may make you feel drowsy or sleepy. Do not drive or operate machinery if you are affected after taking this medicine.
PROBENECID should be used with caution if you have liver problems. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
PROBENECID should be used with caution if you have kidney disorders. Inform your doctor if you have kidney problems like kidney stones. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
PROBENECID is not recommended for use in children below two years of age as the safety and efficacy are not established.
Gout: It is a type of inflammatory (allergic reaction) condition that forms uric acid crystals and gets accumulated inside feet, knuckles, and surrounding bone joints. This occurs due to high uric acid levels in the blood, resulting in immense pain in joints. The pain may be severe, but the condition improves with medication. To avoid bone and cartilage damage and weakening of the kidneys, repeated gout attacks can require long-term medication. In areas such as the wrists, elbows, feet, or earlobes, chronic gout sufferers can feel small hard lumps forming over time in the soft flesh. These deposits are concentrations of uric acid crystals, called tophi, and over time can cause pain and stiffness.