About PROTHIONAMIDE
PROTHIONAMIDE belongs to a class of medications known as anti-tuberculosis (antibiotics) drugs primarily used to treat and prevent tuberculosis (TB). Tuberculosis is a bacterial infection that mainly affects the lungs and can spread to other body parts like the brain and spine.
PROTHIONAMIDE consists of a medicine called Prothionamide. Prothionamide is clinically effective in treating TB; the precise mechanisms of action remain unknown, but a cell-based activation method causes an inhibiting complex.
Follow the dose and duration as advised by your doctor, preferably at the same time every day. Finish the full course of treatment, and do not skip any doses even if you start feeling good. Discontinuing its use on your own can result in treatment failure and the development of drug-resistant tuberculosis, leading to serious health complications. If you miss a dose, take it at the earliest. However, do not take double doses or overdose to fulfil missed doses as it may increase the side effects. Some people may experience nausea, vomiting, diarrhoea, stomach pain, increased salivation, metallic taste in the mouth, headache, dizziness, and drowsiness as side effects of this medicine. Please speak with your doctor if these side effects do not resolve or worsen. It is advised to take antacids containing aluminium at least 4 hours before or after taking PROTHIONAMIDE to avoid drug interaction.
If you are allergic to PROTHIONAMIDE or any other medicines. Consult your doctor before taking PROTHIONAMIDE if you are pregnant. Avoid breastfeeding while taking PROTHIONAMIDE as it passes into breast milk. Take PROTHIONAMIDE with caution if you have diabetes. PROTHIONAMIDE may rarely cause dizziness, and vision problems, so drive with caution if you experience these signs. Avoid consuming alcohol with PROTHIONAMIDE as it might lead to liver problems or mental/mood changes. Do not take PROTHIONAMIDE if you have severe liver disease. Inform your doctor immediately if you experience/notice confusion, seizure, dark urine, or clay-coloured stools after taking PROTHIONAMIDE.
Uses of PROTHIONAMIDE
Tuberculosis
Medicinal Benefits
PROTHIONAMIDE consists of a medicine called Prothionamide. Prothionamide is clinically effective in treating TB; the precise mechanisms of action remain unknown, but a cell-based activation method causes an inhibiting complex.
Directions for Use
Storage
Side Effects of PROTHIONAMIDE
- Nausea
- Vomiting
- Diarrhoea
- Stomach pain
- Metallic taste in your mouth
- Headache
- Dizziness
- Drowsiness
In-Depth Precautions and Warning
Drug Warnings
Before starting PROTHIONAMIDE, please inform your doctor if you have a medical history, especially of: liver disease, underactive thyroid (hypothyroidism), kidney disease, eye problems (such as optic neuritis, cataracts). Take PROTHIONAMIDE with caution if you have diabetes. PROTHIONAMIDE may lower your blood sugar levels. Also, check your blood sugar level regularly as directed by your doctor. Consult your doctor before taking PROTHIONAMIDE if you are pregnant. This medication is not recommended for use in pregnant women. Avoid breastfeeding while taking PROTHIONAMIDE as it passes into breast milk. PROTHIONAMIDE may cause dizziness, and vision problems, so drive with caution. Avoid consuming alcohol along with PROTHIONAMIDE as it might lead to liver problems or mental/mood changes.
Drug Interactions
Drug-Drug Interactions: PROTHIONAMIDE may interact with other antituberculosis agents/ antibiotics (e.g. Isoniazid, P-amino salicylic acid, Cycloserine, and Rifampicin). The relevance of a particular drug interaction varies from person to person. Always consult your healthcare provider before starting or stopping any medication, and also inform your doctor about all your medical conditions and ongoing therapies before prescribing this medication. By considering these, your doctor may check the drug interactions before prescribing this medication.
Food-Drug Interactions: Do not consume alcohol while taking PROTHIONAMIDE as it could lead to increased dizziness or mental/mood changes.
Drug-Disease Interactions: PROTHIONAMIDE may interact with liver disease, vision problems, diabetes, or a thyroid disorder.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionConsuming alcohol along with PROTHIONAMIDE is not advisable as it may cause unpleasant side effects.
Pregnancy
cautionPlease consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
cautionPlease consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.
Driving
cautionPatients who experience dizziness or lightheadedness while receiving PROTHIONAMIDE should refrain from operating machinery.
Liver
cautionThere is limited information available on the use of PROTHIONAMIDE in patients with liver disease. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.
Kidney
cautionThere is limited information available on the use of PROTHIONAMIDE in patients with Kidney disease. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Please consult your doctor.
Children
cautionPROTHIONAMIDE is not recommended for children below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
- Foods rich in vitamin C such as kiwi, broccoli, and bell pepper, help improve the immune system.
- Avoid processed and fried foods.
- Warm ginger tea or warm soup can help in providing relief from cough.
- Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
- Quit smoking and avoid alcohol consumption.
Special Advise
- Your doctor may advise you to get regular liver tests while taking PROTHIONAMIDE to check how your liver functions.
- You may need frequent blood tests to check your liver and thyroid function. You may also need frequent eye exams.
- If you have diabetes, check your blood sugar levels carefully while on this medication.
Patients Concern
Disease/Condition Glossary
Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.
