RETEPLASE is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to lower the risk of heart failure and death. STEMI is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries.
RETEPLASE contains Reteplase, which works by dissolving the blood clot that is blocking the heart blood vessel.
In some cases, RETEPLASE may cause side effects such as bleeding, bruising at the injection site, nausea or vomiting. You are advised to talk to your doctor if any of the side effects persist or worsen.
Consult your doctor if you are pregnant or breastfeeding. The efficacy and safety of RETEPLASE in children have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.
ST-elevation myocardial infarction (STEMI)
RETEPLASE is a tissue plasminogen activator indicated for the treatment of acute ST-elevation myocardial infarction (STEMI) to reduce the risk of heart failure and death. RETEPLASE contains Reteplase that works by dissolving the blood clot that is blocking the heart blood vessel. It may also be indicated in the treatment of a recent left bundle branch block (a delay/blockage of electrical impulses to the left side of the heart).
RETEPLASE should not be used if you are allergic to any of the components in RETEPLASE, in patients with active internal bleeding, recent stroke, recent intracranial or intraspinal surgery or serious head trauma, intracranial neoplasm (brain tumour), arteriovenous malformation, or aneurysm (ballooning and weakened area in an artery), known bleeding diathesis (tendency to bleed or bruise easily), or severe uncontrolled hypertension. RETEPLASE may cause bleeding, hypersensitivity reactions, or cholesterol embolism. Inform your doctor if you have/had recent major surgery, cerebrovascular disease, recent gastrointestinal/genitourinary bleeding, hypertension, subacute bacterial endocarditis, severe hepatic or renal disease, if you are over 75 years or if you are taking any oral anticoagulants. Consult your doctor if you are pregnant or breastfeeding. The safety and effectiveness of RETEPLASE in children have not been established.
Drug-Drug Interactions: Inform your doctor if you are taking anti-coagulants (heparin, enoxaparin, warfarin, phenindione, aspirin, dipyridamole, ticlopidine, clopidogrel, vitamin K antagonists).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have/had cancer, stroke, high blood pressure, active ulcer in the stomach or intestine, portal hypertension, inflammation of the pancreas, bleeding behind or in the eye, or severe liver or kidney problems.
Limited information is available. Please consult your doctor.
Please consult your doctor if you are pregnant. Your doctor will prescribe only if the potential benefits outweigh the potential risk to the foetus.
Please consult your doctor if you are breastfeeding. Caution should be exercised whilst administering RETEPLASE to a nursing mother.
Limited information is available. Please consult your doctor.
The potential risks with the therapy of RETEPLASE may be increased in patients with severe liver dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.
The potential risks of RETEPLASE therapy may be increased in patients with severe renal dysfunction and should be weighed against the anticipated benefits. Please consult your doctor.
The efficacy and safety of RETEPLASE in children have not been established.
ST-elevation myocardial infarction (STEMI): It is a very serious type of heart attack that occurs due to blockage of the heart’s major arteries. Signs and symptoms include dizziness or light-headedness, chest pain or discomfort, shortness of breath, nausea or vomiting, palpitations, anxiety, or sweatiness unexplained by ambient temperature.