Sodium Hyaluronate
About Sodium Hyaluronate
Sodium Hyaluronate is a specialised injection used to relieve joint pain in people with osteoarthritis. It is typically prescribed when other treatments, such as pain relievers or physical therapy, have not provided enough relief. This treatment helps reduce pain and stiffness, making it easier for you to perform your daily activities.
This medicine is injected directly into the affected joint by a healthcare professional, usually as a single dose or a series of weekly injections depending on your treatment plan. Before the injection, your doctor may examine the joint and, if necessary, remove excess joint fluid to improve comfort and the effectiveness of the treatment. The injection procedure usually takes only a few minutes. To get the best results, it helps to combine the injections with gentle physical therapy and regular, low-impact exercise. Managing your body weight also helps reduce stress on your joints during recovery.
Some people may experience mild temporary side effects, such as mild pain, swelling, or redness at the injection site. These reactions usually go away on their own within a few days. However, you should contact your doctor immediately if you notice signs of infection, such as fever, worsening pain, or severe swelling around the joint.
Do not use Sodium Hyaluronate if you have an infection in or around the joint being treated, or if you have an active skin disease in the area where the injection is given. It is important to talk to your doctor before starting this treatment if you have poor blood circulation or severe swelling in your legs.
This medicine can interact with certain skin disinfectants, specifically those containing quaternary ammonium salts, so they should not be used on your skin at the same time. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, talk to your doctor or pharmacist to ensure this treatment is safe and appropriate for you.
Uses of Sodium Hyaluronate
Medicinal Benefits
Sodium Hyaluronate helps relieve joint pain caused by osteoarthritis by restoring the natural cushioning and lubrication within the joint. It improves joint movement and supports better physical function.
- Relieves Joint Pain: Helps reduce pain and discomfort caused by osteoarthritis by improving joint lubrication.
- Improves Joint Mobility: Enhances flexibility and ease of movement, making daily activities more comfortable.
- Restores Joint Lubrication: Acts as a supplement to the natural joint fluid, reducing friction between bones during movement.
- Supports Physical Activity: Improved joint function may help you participate more comfortably in exercise, physiotherapy, and routine activities.
- Provides Localised Relief: As it is injected directly into the affected joint, it offers targeted treatment with minimal systemic side effects.
Directions for Use
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Sodium Hyaluronate will be administered by the doctor or healthcare professional.
- Do not self-administer.
Storage
Side Effects of Sodium Hyaluronate
Common Side Effects (Usually mild)
- Mild pain or throbbing at the injection site
- Slight swelling, warmth, or redness around the joint
- Minor bruising where the needle entered
- Fluid buildup in the injected joint
Serious Side Effects (Consult your doctor right away)
- Signs of infection, such as a fever, severe swelling, heat, or worsening pain in the joint
- Signs of an allergic reaction, including skin rash, hives, itching, or swelling of the face, lips, or throat
- Severe pain or inability to put weight on the treated leg
Medicines Containing this Salt
View AllDrug Warnings
- Ensure Proper Packaging: Before the injection, ensure the syringe packaging is intact and the sterile seal has not been broken.
- Rest the Treated Joint: Avoid strenuous activities such as running, heavy lifting, or prolonged standing for at least 48 hours after the injection.
- Avoid Injection into Infected Skin: Do not receive the injection if the skin over the joint is red, swollen, infected, or irritated.
- Maintain Sterile Technique: Ensure the injection site is cleaned thoroughly with an appropriate antiseptic before administration.
- Inform Your Doctor About Allergies: Tell your doctor if you have allergies to bird products, such as feathers, eggs, or poultry, as some formulations may contain related proteins.
Drug Interactions
- Quaternary ammonium disinfectants (like benzalkonium chloride): Do not use these skin disinfectants before or during the injection procedure. They can cause the medicine to clump together inside the joint, reducing its effectiveness and increasing irritation.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
consult your doctorThe interaction of Sodium Hyaluronate with alcohol is unknown. If you have any concerns regarding this, please discuss them with your doctor.
Pregnancy
consult your doctorThe safety and effectiveness of Sodium Hyaluronate in pregnant women have not been established. Therefore, if you are pregnant or planning for pregnancy, please inform your doctor before receiving Sodium Hyaluronate.
Breast Feeding
consult your doctorThe safety and effectiveness of Sodium Hyaluronate in breastfeeding women have not been established. Therefore, please inform your doctor if you are breastfeeding before receiving Sodium Hyaluronate.
Driving
cautionDrive only if you are alert after receiving Sodium Hyaluronate.
Liver
consult your doctorIf you have a pre-existing or a history of liver disease, please inform your doctor before receiving Sodium Hyaluronate.
Kidney
consult your doctorIf you have a pre-existing or a history of kidney disease, please inform your doctor before receiving Sodium Hyaluronate.
Children
unsafeSodium Hyaluronate is not recommended for children and adolescents (age 21 years or younger) as the safety and effectiveness of Sodium Hyaluronate have not been established in that age group.
Habit Forming
Diet & Lifestyle Advise
- Maintain a Healthy Weight: Achieving and maintaining a healthy body weight helps reduce stress on weight-bearing joints such as the knees.
- Choose Low-Impact Exercise: Activities such as swimming, cycling, and water aerobics can help improve joint flexibility without placing excessive strain on the joints.
- Use Cold Compresses if Needed: Applying a cold pack to the treated joint after activity may help relieve mild temporary swelling or discomfort.
- Eat a Joint-Healthy Diet: Include foods rich in calcium, vitamin D, and anti-inflammatory nutrients, such as leafy green vegetables, to support bone and joint health.
Patients Concern
Disease/Condition Glossary
Osteoarthritis: It is a degenerative joint disease that occurs when the concentration of sodium hyaluronate in joints decreases. Hyaluronic acid is found in the joints, which lubricates and provides a cushion between two bones. When Hyaluronic acid gets reduced, it causes the bones to rub together, leading to pain, stiffness, and other osteoarthritis symptoms. This disease can occur in any joint, but commonly affected areas of the body are hands, fingertips, knees, hips, and spine, typically at the neck or lower back. The most common osteoarthritis symptoms include pain, tenderness (discomfort when pressing on the area with fingers), stiffness, and inflammation. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints and ligament injuries.
FAQs
Sodium Hyaluronate is used in the treatment of knee pain due to osteoarthritis in patients who have failed to respond adequately to simple painkillers or physical therapy and exercise.
Sodium Hyaluronate contains Sodium hyaluronate, a non-steroidal anti-inflammatory drug (NSAID) which works by restoring synovial fluid in the knee that helps to lubricate and cushion the joint during movement. Thereby it reduces knee pain due to osteoarthritis.
You are recommended to avoid activities such as tennis, heavy lifting, jogging, or standing on your feet for a long time immediately after receiving Sodium Hyaluronate and for the next 48 hours. Discuss with your doctor regarding the appropriate time to resume these activities.
Sodium Hyaluronate should not be used in patients with infections, knee joint infections, or skin disease in the area at the injection site. Also, Sodium Hyaluronate should not be administered to patients with known allergies to Sodium hyaluronate.
It is injected directly into the joint space by a trained healthcare professional in a medical clinic. Talk to your doctor for more details about how the procedure is performed.
Yes, you can usually perform light walking immediately after the procedure. However, you must avoid prolonged standing, heavy lifting, or strenuous exercise for at least 48 hours. Talk to your doctor about your specific recovery plan.
The treatment course depends on the specific product prescribed by your healthcare provider. It can range from a single injection to a series of three to five injections given weekly. Talk to your doctor to understand your personalised plan.
There is limited research on the safety of this injection in pregnant or breastfeeding women. Talk to your doctor or pharmacist to weigh the potential benefits and risks before starting treatment.
No, this treatment does not cure osteoarthritis, but it helps manage the pain and stiffness associated with the condition to improve your daily movement. Talk to your doctor about long-term joint management strategies.
Severe swelling, redness, heat, or worsening pain can be signs of an infection or an unwanted reaction. Contact your doctor immediately or seek urgent medical attention if you experience these symptoms.

