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About VARENICLINE

VARENICLINE belongs to the class of 'smoking cessation aids,' primarily used to treat nicotine addiction. Nicotine is an addictive chemical found in the tobacco plant. It produces pleasing effects on the brain when a person smokes a cigarette. Though the effect is temporary, it leads to the compulsive craving for one more cigarette. This continuous process of wanting to smoke despite a strong will to quit smoking is known as nicotine addiction/nicotine dependence.

VARENICLINE contains 'Varenicline,' which belongs to the class of 'nicotinic agonists. It blocks the effects of nicotine by acting on the nicotinic receptors in the central nervous system. VARENICLINE helps in reducing the craving and withdrawal symptoms that occur after quitting smoking. It decreases the sense of satisfaction or enjoyment that occurs while smoking, thereby helping adults quit smoking.

Your doctor will advise the dose and duration to take VARENICLINE based on your condition. The common side effects of VARENICLINE include nausea, headache, vomiting, drowsiness, gas, constipation, trouble sleeping or insomnia, unusual dreams, and taste changes. Most of these side effects of VARENICLINE do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please seek medical help. 

Try not to stop taking this medicine of your own. Brief your medical history if you have any heart, liver, kidney diseases, seizure (fits), mood disorders, and alcoholism before taking VARENICLINE. Please inform your doctor if you are pregnant or currently breastfeeding before taking VARENICLINE. Do not drive or operate machinery while using VARENICLINE since it can cause sleepiness and dizziness. Avoid drinking alcohol while taking VARENICLINE as it can worsen your dizziness. VARENICLINE is not recommended for use in patients younger than 18 years of age.

Uses of VARENICLINE

Nicotine addiction.

Medicinal Benefits

VARENICLINE works as an aid in curing a nicotine addiction. It contains 'Varenicline,' which is a smoking cessation aid. It is a nicotinic agonist and blocks nicotine's effects by acting on the nicotinic receptors in the central nervous system. VARENICLINE reduces the craving and withdrawal symptoms that occur after quitting smoking and during the treatment. It also decreases the sense of satisfaction or enjoyment that occurs while smoking, thereby helping adults quit smoking. It is advised to provide the patients who are striving to quit smoking with proper emotional support and educational material while undergoing treatment with VARENICLINE.

Directions for Use

There are three ways to use the tablet. You can choose any way of using VARENICLINE under the supervision of your doctor. Take the tablet with a glass of water and preferably with food. 1. Set a date to give up smoking and start VARENICLINE a week exactly before the set date. Make sure that you quit smoking on the date decided. Take VARENICLINE for a period of 12 weeks in the dose and duration suggested by your doctor. 2. Start taking VARENICLINE and decide a date to quit smoking between 8-35 days after you start treatment. Take VARENICLINE for 12 weeks in the dose and duration suggested by your doctor. 3. Start taking the tablet and decrease the number of cigarettes you smoke every day gradually for a 12-week period until you completely stop smoking. Then take it for more than 12 weeks for a total of 24 week period in the dose and duration suggested by the doctor. The above usage ways are for reference only. Please consult your doctor for the best advice on how to use VARENICLINE.

Storage

Store in a cool and dry place away from sunlight

Side Effects of VARENICLINE

  • Nausea
  • Headache
  • Vomiting
  • Drowsiness
  • Gas
  • Constipation
  • Trouble sleeping or insomnia
  • Unusual dreams 
  • Changes in taste 

In-Depth Precautions and Warning

Drug Warnings

Inform your doctor if you have any liver, kidney diseases, mood disorders (depression, schizophrenia, bipolar disorder), heart diseases (coronary artery disease, stroke), fits, blood vessel disorders (peripheral vascular disease), alcoholism, and drug abuse before taking. Neuropsychiatric events like depression, delusions, hallucinations, aggression, suicidal thoughts, and suicidal attempts are reported in patients using VARENICLINE. If you experience any mood changes, please stop taking VARENICLINE and consult your doctor immediately. Also, let your doctor know if you are pregnant or a lactating mother before starting VARENICLINE. Do not drive or operate machinery if you experience dizziness and sleepiness while using VARENICLINE. Drinking alcohol can worsen your side effects like dizziness and drowsiness when you are treated with VARENICLINE; hence please avoid alcohol consumption. VARENICLINE is not recommended in patients younger than 18 years of age. 

Drug Interactions

Drug-Drug Interaction: VARENICLINE may interact with antidiabetics (insulin), blood thinners (warfarin), anti-ulcers (cimetidine), HIV/AIDS drugs (dolutegravir), chest pain medicines (ranolazine), anti-cancers (vandetanib), and respiratory drugs (theophylline).

Drug-Food Interaction: Avoid alcohol intake since it may worsen the side effects like dizziness and drowsiness. 

Drug-Disease Interaction: VARENICLINE is to be cautiously used in liver, kidney diseases, mood disorders (depression, schizophrenia, bipolar disorder), heart diseases (coronary artery disease, stroke), fits, blood vessel disorders (peripheral vascular disease), alcoholism, and drug abuse.

Drug-Drug Interactions Checker List:

  • INSULIN
  • WARFARIN
  • THEOPHYLLINE
  • CIMETIDINE
  • DOLUTEGRAVIR
  • RANOLAZINE
  • VANDETANIB

    • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid drinking alcohol while taking VARENICLINE as it can worsen your side effects like dizziness and drowsiness.

    • Safety Warning

      Pregnancy

      caution

      VARENICLINE is a pregnancy category C drug. Animal studies of VARENICLINE during pregnancy showed harmful effects on developing baby. Please consult your doctor if you are planning to become pregnant or already pregnant before starting VARENICLINE.

    • Safety Warning

      Breast Feeding

      caution

      There is limited data on how VARENICLINE affects breastfeeding. However, using VARENICLINE while breastfeeding may make the breastfed infant vomit or develop a seizure/fits. It is advised to decide on discontinuing VARENICLINE or discontinuing breastfeeding. Please consult your doctor for more information.

    • Safety Warning

      Driving

      unsafe

      Do not drive or operate machinery if you experience dizziness and drowsiness while using VARENICLINE.

    • Safety Warning

      Liver

      caution

      VARENICLINE should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing VARENICLINE.

    • Safety Warning

      Kidney

      caution

      VARENICLINE should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing VARENICLINE.

    • Safety Warning

      Children

      unsafe

      VARENICLINE is not recommended in children or adolescents younger than 18 years of age.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Do not worry about the cravings of smoking you need to hold up in the next few weeks of course. Take it one step at a time. 
    • You can get a hold of your cravings by keeping your mouth busy with a piece of gum or candy.
    • Your doctor may also suggest nicotine replacement therapy. You can try gums, lozenges, or patches.
    • Avoid triggers that make you crave a cigarette. These include alcohol, caffeine and people who smoke nearby.
    • You can also try going to non-smoking public areas to divert your mind.
    • Go for a walk in nature for a quick exercise.
    • If you feel like giving up, remember why you started and what made you try this hard to quit smoking.
    • Lastly, accept yourself and embrace your family support in encouraging you to quit smoking.

    Special Advise

    • Close monitoring of renal function is advised in renal failure or kidney disease patients.
    • Keep a check on your heart condition (if you are a heart disease patient) with an electrocardiogram (ECG).
    • It is recommended to take advice from a mental health doctor if you notice any mood changes and suicidal thoughts while using VARENICLINE.

    Patients Concern

    Disease/Condition Glossary

    Nicotine addiction: Nicotine is an addictive chemical found in the tobacco plant. It produces pleasing effects on the brain when a person smokes a cigarette. This effect is temporary, but it leads to the compulsive craving for one more cigarette. This continuous process of wanting to smoke despite a strong will to quit smoking is known as nicotine addiction/nicotine dependence. Symptoms include frequently failing to stop smoking, giving up social gatherings to smoke, and withdrawal symptoms when trying to quit smoking. Starting to smoke at a young age (18 years) is also a primary reason for nicotine addiction. Anyone with a history of alcoholism or drug abuse is at an increased risk of developing a nicotine addiction.

    FAQs

    How does VARENICLINE work?

    VARENICLINE contains Varenicline, a smoking cessation aid. VARENICLINE helps to cure nicotine addiction by decreasing the sense of pleasure you get while smoking and blocks the effect of nicotine chemical by acting on the brain.

    Can I undergo nicotine replacement therapy (NRT) simultaneously while using VARENICLINE?

    You could undergo nicotine replacement therapy while using VARENICLINE only if the doctor advised you to do so. However, using a nicotine patch or other forms of NRT while being treated with VARENICLINE may cause undesired effects. If you experience any worsening of side effects, it is advised to continue one therapy after another or do as prescribed by the doctor.

    In which conditions, should I stay cautious before taking VARENICLINE?

    VARENICLINE should be cautiously used only under a doctor's supervision if you have any liver, kidney diseases, mood disorders (depression, schizophrenia, bipolar disorder), heart diseases (coronary artery disease, stroke), fits, blood vessel disorders (peripheral vascular disease), alcoholism, and drug abuse.

    What happens if I miss a dose of VARENICLINE?

    Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.

    What do I need to know before using VARENICLINE?

    Neuropsychiatric events like depression, delusions, hallucinations, aggression, suicidal thoughts, and suicidal attempts are reported in patients using VARENICLINE. If you experience any mood changes, agitation or depression, please stop taking VARENICLINE and consult your doctor immediately.

    I am a patient with a seizure/fits disorder. Can I take VARENICLINE?

    The occurrence of seizures is reported in patients with a seizure disorder while using VARENICLINE. Hence VARENICLINE is cautiously recommended for use, and close monitoring is required in patients with a history of seizures/fits disorder during the course.

    Will I experience withdrawal symptoms even after using VARENICLINE?

    You may experience withdrawal symptoms with or without the usage of VARENICLINE. Hence, it is advised to closely monitor for any symptoms like increased appetite, weight gain, trouble sleeping, slower heart rate, anxiety, restlessness, and urge to smoke. If you experience any withdrawal symptoms, please seek medical help immediately.

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