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Alprostadil

About Alprostadil

Alprostadil is an injection used to treat erectile dysfunction (impotence) and to help diagnose certain blood flow issues in the penis. It works by widening the blood vessels to increase blood flow, allowing an erection to occur when you are sexually stimulated. This medicine is prescribed when other oral options are not suitable or have not worked well for you.

You should use this medicine exactly when needed, usually no more than once in 24 hours and no more than three times a week. Because it is injected directly, food does not affect how it works, meaning you can use it with or without eating. Making healthy lifestyle choices, like keeping active and managing stress, can also help improve your overall results.

Some common side effects of injection include mild pain or an aching feeling in the penis, minor bleeding at the injection site, or a prolonged erection. If you experience a painful erection that lasts for more than four hours, or if you notice severe bruising or swelling, you must contact your doctor or seek emergency medical help immediately.

Before starting this medicine, tell your doctor if you have a history of bleeding disorders, blood clots, or conditions like sickle cell anaemia or leukaemia. Do not use this medicine if you are allergic to Alprostadil or any of its ingredients, as it may cause a serious allergic reaction.  Do not take this if you have an implant in your penis, or if you have a medical condition where sexual activity is not advised by your doctor.

Using it alongside blood thinners can increase your risk of bleeding or bruising, while combining it with other erectile dysfunction drugs can cause a dangerously prolonged erection. While this medication is not intended for women, elderly individuals should consult their doctor to ensure their heart is healthy enough for sexual activity.

Uses of Alprostadil

Alprostadil is used to manage erectile problems in men. The detailed uses of Alprostadil are as follows: • Treats erectile dysfunction: Alprostadil is used as an injection or suppository to help achieve and maintain an erection in men with impotence. • Assists in diagnosing erectile dysfunction: Alprostadil may be used alongside certain tests to evaluate erectile problems. • Acts as a vasodilator: Alprostadil works by relaxing muscles and blood vessels in the penis to improve blood flow needed for an erection.

Medicinal Benefits

When taken consistently as directed, this medication may provide the following health benefits:

  • Provides reliable erectile support: This medicine is injected directly into the penis, where it works quickly, typically producing an erection within 5 to 20 minutes. This helps improve confidence and sexual performance during intimate moments.
  • An alternative to oral medicines: This medicine is an effective option for people who cannot take oral treatments because of certain medical conditions or drug interactions. By helping achieve and maintain an erection suitable for sexual activity, it supports a more satisfying intimate life.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication. Inject not more than 3 times a week, with at least 24 hours between doses.
  • Your healthcare provider will show you how to prepare and inject Alprostadil. Check the label for directions and use it as advised by the doctor. Make yourself comfortable and sit upright or slightly reclined and inject Alprostadil into the penis.
  • Change the side of the shaft of the penis, and choose a different location for each injection. To minimise the risk of the needle breaking, make sure you use the proper needle as instructed by your doctor.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Alprostadil

Common Side Effects (Usually mild):

  • Mild to moderate pain or burning in the penis during or after injection
  • Small amount of bleeding or minor bruising at the injection site
  • Redness or warmth in the genital area
  • Headache or mild dizziness
     

Serious Side Effects (Consult your doctor right away):

  • An erection that lasts longer than 4 hours
  • Severe pain, swelling, or bending of the penis during an erection
  • Hives, trouble breathing, or swelling of the face, lips, or throat (signs of a severe allergic reaction)
  • Scar tissue or changes in the shape of the penis with repeated injections
  • Numbness, coldness, or changes in skin colour on the penis

Drug Warnings

  • Inspect before use: Always inspect the solution before injection. Do not use it if you notice cloudiness, discolouration, or floating particles.
  • Long-term use: Repeated injections into the same area may cause scarring or penile fibrosis, which can lead to curvature of the penis (such as Peyronie's disease). Rotating injection sites and following your doctor's instructions can help reduce this risk.
  • Use a new needle every time: Never reuse needles or syringes. Always use a sterile, single-use needle for each injection to help prevent infections.
  • Avoid damaged areas: Do not inject into areas of the penis that are red, bruised, infected, or scarred.
  • Seek urgent medical help if needed: Stop using the medicine and seek immediate medical attention if you experience chest pain, fainting, or sudden vision changes during sexual activity after the injection.

Drug Interactions

  • Blood thinners: Using injection with medications that prevent blood clots (like warfarin or aspirin) may increase your risk of bleeding or bruising at the injection site.
  • High blood pressure medications: Combining this injection with drugs that lower blood pressure may cause your blood pressure to drop too low, leading to dizziness or fainting.
  • Other erectile dysfunction treatments: Taking other ED medications (like oral tablets) alongside this injection can cause a dangerously prolonged erection.

Drug-Drug Interactions Checker List:

  • AMLODIPINE
  • LISINOPRIL
  • TAMSULOSIN
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • PHENOBARBITAL
  • PHENYTOIN
  • CARBAMAZEPINE
  • RIFAMPICIN
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      Avoid alcohol consumption during treatment with Alprostadil as it may cause increased dizziness.

    • Safety Warning

      Pregnancy

      not applicable

      Alprostadil is only recommended for adult men.

    • Safety Warning

      Breast Feeding

      not applicable

      Alprostadil is only recommended for adult men.

    • Safety Warning

      Driving

      caution

      Alprostadil may cause dizziness. Therefore, you are advised to drive and operate machinery only if you are alert.

    • Safety Warning

      Liver

      caution

      If you have a pre-existing or a history of liver disease, inform your doctor before using Alprostadil. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

    • Safety Warning

      Kidney

      caution

      If you have a pre-existing or history of liver disease, inform your doctor before using Alprostadil. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

    • Safety Warning

      Children

      not applicable

      Alprostadil is only recommended for adult men.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Limit alcohol intake: Drinking alcohol can decrease your ability to get an erection and may worsen some side effects, like dizziness or low blood pressure.
    • Quit smoking: Tobacco use damages blood vessels and reduces blood flow throughout the body, which can make erectile dysfunction treatments less effective.
    • Stay active: Regular, moderate cardiovascular exercise helps improve blood circulation, supporting the natural mechanisms of this medication.
    • Manage stress and anxiety: Psychological factors play a significant role in sexual performance; practising relaxation techniques can enhance the physical benefits of the treatment.

    Special Advise

    • Do not take Alprostadil more than once a day. Take Alprostadil as prescribed by the doctor.
    • Talk to your doctor if the erection persists for greater than four hours.
    • Alprostadil is only intended for use in men. Avoid using it for women and children.
    • Intended to be administered through the intracavernosal route only. Hence avoid using it for IM or IV route.

    Patients Concern

    Disease/Condition Glossary

    Erectile dysfunction: Erectile dysfunction, also known as impotence, is defined as the difficulty of keeping a hard and erect penis that is firm enough and suitable for sexual activity. It could be a sign of physical or psychological conditions such as fear of sexual failure, anxiety, depression, low self-esteem, or stress. Certain health-related factors such as smoking, drinking, being overweight, being physically inactive, and high blood pressure also contribute to erectile dysfunction. Symptoms of erectile dysfunction include difficulty in getting an erection, difficulty in maintaining the erection during intercourse and decreased sexual desire.

    FAQs

    Alprostadil is used to treat Erectile dysfunction (impotence).

    No, do not take Alprostadil with nitrates. Taking Alprostadil with medicines used to treat angina/chest pain, such as nitrates/nitroglycerin, may cause severe lowering of blood pressure. You are advised not to take Alprostadil if you are taking nitrates or have a history of heart attack/stroke.

    Alprostadil works by relaxing the blood vessels in the penis, allowing blood to flow into the penis when the person is sexually excited.

    Do not increase the dose on your own. Your doctor may gradually adjust your dose based on how well the medicine works and whether you experience any side effects. Always use the dose prescribed by your doctor.

    Combining this injection with blood pressure drugs can sometimes cause your blood pressure to drop, making you feel dizzy or lightheaded. Your doctor may need to adjust your dose or monitor you closely. Talk to your doctor to see if this combination is safe for you.

    No, this medication only helps you achieve an erection and does not provide any protection against sexually transmitted infections (STIs) or pregnancy. You should use barrier methods like condoms for protection. Talk to your doctor or pharmacist if you need advice on safe sex practices.

    It is best to avoid or strictly limit alcohol before or after using this injection. Alcohol can make it harder to get an erection and increases the risk of side effects like dizziness and low blood pressure. Talk to your doctor about safe alcohol limits.

    Mild bleeding or a small bruise can occasionally happen. Press firmly on the site with a clean cotton ball for at least three minutes to stop the bleeding. If the bruising is severe, painful, or does not improve, talk to your doctor.

    Yes, but you must keep it cool during travel by using an insulated travel bag with ice packs. Do not let the medicine freeze or sit in direct sunlight. Talk to your pharmacist for specific travel accessories and storage advice.

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