Amisulpride
About Amisulpride
Amisulpride is primarily used to treat long-term (chronic) schizophrenia. In schizophrenic disorders, there are positive symptoms (like delusions, hallucinations and thought disorders) along with negative symptoms (like blunted affect, emotional and social withdrawal).
Amisulpride contains amisulpride, which helps balance dopamine activity in the brain. It improves thinking, mood, and behaviour while reducing abnormal mental symptoms. It also supports better emotional and social functioning. This helps maintain mental stability and daily well-being.
Take Amisulpride as prescribed by your doctor. Common side effects include drowsiness, dizziness, weight gain, increased appetite, nausea, vomiting, constipation, dry mouth, blurred vision, insomnia (trouble sleeping), anxiety, or agitation (feeling restless or uneasy). If you notice any side effects that are not manageable, please consult your doctor.
Amisulpride should be avoided if you are allergic to it or any other medicines. Amisulpride is not recommended for children under 18 years. Amisulpride should not be taken if you are pregnant or breastfeeding. Use Amisulpride with extreme caution in elderly patients above 65 years of age, as there is an increased risk of severe adverse effects.
Uses of Amisulpride
Medicinal Benefits
- Helps reduce hallucinations, delusions, and disturbed thinking.
- Improves clarity of thoughts and emotional control.
- Supports better daily functioning and social interaction.
- Helps manage both acute and long-term symptoms.
- Improves overall quality of life and mental stability.
Directions for Use
- Amisulpride can be taken before meals or as advised by your doctor.
- Take Amisulpride twice daily; however, follow your doctor’s recommendation regarding the dosage and duration.
- Swallow the medicines as a whole with a glass of water.
- Do not crush, chew, or break it.
Storage
Side Effects of Amisulpride
- Dizziness
- Drowsiness
- Difficulty sleeping (insomnia) or feeling anxious or agitated
- Lightheadedness
- Blurred vision
- Dry mouth
- Constipation
- Weight gain
- Decreased blood pressure
- Dystonia (involuntary muscle contractions)
- Akathisia (inability to stay still)
- Parkinsonism
- Breast enlargement in men
- Unusual production of breast milk in women and men, breast pain
Medicines Containing this Salt
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Drug Warnings
- Do not take Amisulpride if you are allergic (hypersensitive) to amisulpride or any other ingredients present in this medicine or have a medical history of prolactin-dependent tumour or breast cancer, phaeochromocytoma (a tumour on the adrenal gland), or pituitary tumour.
- Amisulpride should not be given to children as safety has not been established.
- Use Amisulpride with extreme caution in elderly patients above 65 years of age, as there is an increased risk of severe adverse effects.
- Amisulpride should not be taken if you are pregnant or breastfeeding. Amisulpride may impair fertility, so inform your doctor if you are planning a pregnancy.
- Inform your doctor if you are previously diagnosed with kidney disease, liver disease epilepsy or seizures (fits), Parkinson's disease, unusual heart rate (rhythm), slow heartbeat (less than 55 beats per minute), low potassium levels in your blood, prolonged QT interval (heart conduction problem), if you or someone else in your family has a history of blood clots, heart problems, stroke, diabetes, have a low number of white blood cells (agranulocytosis), leucopenia (blood disorder).
- Amisulpride may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Amisulpride as it could lead to increased drowsiness and dizziness.
Drug Interactions
Drug-Drug Interaction: Inform your doctor if you are taking any of the following medicines, as there may be an interaction.
- Heart rhythm medicine – Antiarrhythmic (Dronedarone)
• Potential effect: May increase the risk of severe irregular heart rhythm and serious cardiac side effects. - Stomach-movement medicines (Cisapride, Metoclopramide)
• Potential effect: May increase the risk of irregular heart rhythm, especially in patients with heart problems. - Antipsychotic medicines (Pimozide, Ziprasidone)
• Potential effect: May increase the risk of severe irregular heart rhythm and lead to serious side effects. - Anti-HIV medicine (Saquinavir)
• Potential effect: May increase the risk of severe irregular heart rhythm. - Antibiotic medicine (Grepafloxacin)
• Potential effect: May increase the risk of severe irregular heart rhythm. - Heart-related medicine used for chest pain (Ranolazine)
• Potential effect: May increase the risk of severe irregular heart rhythm when used together.
Drug- Food Interaction:
- Grapefruit juice and Alcohol: Avoid grapefruit juice and alcohol while taking Amisulpride, as they may increase the risk of side effects.
Drug-Disease Interaction: Inform your doctor if you have a history of this condition before taking Amisulpride.
- Breast cancer
- Pheochromocytoma (tumour of the adrenal gland)
- Pituitary gland prolactinoma (tumour of the pituitary gland)
- Fits
- Parkinson’s disease
- Kidney problems
- Heart problems
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Amisulpride as it may lead to increased dizziness and drowsiness.
Pregnancy
cautionAmisulpride should not be taken by pregnant women. Consult your doctor for further advice.
Breast Feeding
unsafeAmisulpride is unsafe and should not be taken by breastfeeding mothers. Consult your doctor for further advice.
Driving
cautionAmisulpride may cause dizziness, drowsiness and uncontrolled movements. Do not drive or operate machinery unless you are alert.
Liver
cautionTake Amisulpride with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. However, Amisulpride is not recommended for patients with severe liver disease. Inform your doctor immediately if you experience fatigue, loss of appetite, nausea, vomiting, abdominal pain or yellow discolouration of the eyes or skin.
Kidney
cautionAmisulpride should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustments and regular monitoring of electrolytes may be required as it may alter electrolyte levels in the body.
Children
unsafeAmisulpride should not be given to children, as its safety and effectiveness have not been established.
Habit Forming
Diet & Lifestyle Advise
Mood Monitoring:
- Track your mood regularly alongside sleep, medications, and daily activities.
- Noting patterns can help manage mood changes better.
Physical Activity:
- Exercise daily to relieve tension and improve mental well-being.
- Regular physical activity also helps prevent weight gain related to medications.
Stress Management:
- Practice calming techniques like meditation and deep breathing.
- These methods help reduce stress and emotional strain.
Sleep Routine:
- Get enough sleep each night to help stabilise mood.
- Maintain a regular sleep schedule.
Diet:
- Eat a healthy, balanced diet to support mental health.
- Keep a food log to see how certain foods affect your mood.
- Discuss diet choices with your doctor or nutritionist if needed.
Positive Mindset:
- Stay optimistic and patient with treatment progress.
- Improvement takes time, and consistent care supports recovery.
Special Advise
- Amisulpride is not recommended for use in children below 18 years of age.
- Amisulpride should be used with caution in older patients (above 65 years) and Parkinson's patients.
Patients Concern
Disease/Condition Glossary
Schizophrenia (psychosis): It is a mental illness in which brain information processing is affected. Patients with schizophrenia develop symptoms such as hallucinations (seeing or hearing unreal things), delusions (false beliefs) and become withdrawn from society. They lose the ability to differentiate reality from false beliefs. Schizophrenia and bipolar disorder may occur due to genetic factors, alcohol or drug abuse, or mental trauma. Schizophrenia may also occur due to traumatic brain injuries or other diseases.
FAQs
Amisulpride is used to treat long-term (chronic) schizophrenia.
Amisulpride contains amisulpride, which works by balancing dopamine activity in the brain. It improves thinking, mood, and behaviour while reducing abnormal mental symptoms.
Amisulpride can be used to treat psychotic disorders like schizophrenia, bipolar disorder and depression. However, you should not take this medication without a doctor's advice.
Amisulpride may affect fertility as it may cause hyperprolactinemia (excessive levels of prolactin hormone in the blood) resulting in amenorrhea (absence of menstrual periods), anovulation (lack of egg release) and impaired fertility.
You are not recommended to stop taking Amisulpride without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Amisulpride for as long as your doctor has prescribed it, and if you experience any difficulty while taking Amisulpride, please consult your doctor so that the dose may be gradually reduced.
Amisulpride is not recommended for dementia (loss of memory or other mental abilities) patients, especially in elderly people, as it may cause severe adverse effects, including stroke. Therefore, it is advised to inform your doctor if you have dementia or a history of stroke before taking Amisulpride.
Stopping Amisulpride abruptly can cause withdrawal symptoms, and stopping it too early could make your illness come back. Please consult your doctor if you want to stop taking Amisulpride.
Take Amisulpride with caution in patients with diabetes, as it may increase the risk of having diabetes. It is advised to monitor your blood sugar levels regularly while taking Amisulpride.
Amisulpride is not recommended for children as the safety and effectiveness have not been established.
Amisulpride should be used with caution and only if prescribed by the doctor in elderly patients due to the possible risk of low blood pressure and sedation.
Amisulpride should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustment and regular electrolyte monitoring may be required, as Amisulpride may alter electrolyte levels.
Amisulpride may cause sleepiness and drowsiness. Do not drive or operate machinery unless you are alert.
Amisulpride should be taken at the same time daily or as prescribed by the doctor.
Amisulpride modulates certain chemical messengers (dopamine D2) in the brain, which helps regulate mood and behaviour.
No, Amisulpride is not indicated for anxiety. It is used to treat schizophrenia and postoperative nausea and vomiting.
Do not take Amisulpride if you are allergic (hypersensitive) to amisulpride or any other ingredients present in this medicine or have a medical history of prolactin-dependent tumour or breast cancer, phaeochromocytoma (a tumour on the adrenal gland), or pituitary tumour.
No, Amisulpride has no habit-forming tendency and is not addictive.
Withdrawal symptoms of Amisulpride are nausea, vomiting, difficulty sleeping, sweating, extreme restlessness, abnormal movements, or muscle stiffness.
Amisulpride may cause side effects such as dry mouth, constipation, weight gain, decreased blood pressure, dystonia (involuntary muscle contractions), akathisia (inability to remain still), parkinsonism, and increased blood prolactin levels. Most of these side effects of Amisulpride do not require medical attention and gradually resolve over time. However, if the side effects persist, consult your doctor immediately.
