Amlodipine+perindopril
About Amlodipine+perindopril
Amlodipine+perindopril is a prescription oral tablet used to treat high blood pressure (hypertension) and stable coronary artery disease. By lowering elevated blood pressure, this medication helps reduce the risk of serious cardiovascular events like heart attacks and strokes. It combines two complementary blood pressure-lowering ingredients to provide effective, long-term cardiovascular protection.
For the best results, you should take Amlodipine+perindopril consistently at the same time every day, exactly as prescribed by your doctor. It is typically taken once daily in the morning, and it can be taken with or without food. Combining this medication with a low-sodium diet, regular exercise, and stress-reduction techniques can significantly improve your blood pressure readings.
While taking Amlodipine+perindopril, some people may experience mild side effects like a dry cough, headache, dizziness, or mild ankle swelling. However, if you experience serious symptoms such as swelling of your face, lips, or throat, difficulty breathing, or yellowing of your skin or eyes, you must seek immediate medical attention.
Before starting this medication, talk to your doctor if you have a history of kidney disease, liver disease, diabetes, or severe heart issues. Do not take this medicine if you are pregnant, planning to become pregnant, or have a history of severe allergic swelling (angioedema).
Amlodipine+perindopril can interact with potassium supplements, certain pain relievers, and alcohol, which can cause unsafe drops in blood pressure or kidney strain. If you are breastfeeding, pregnant, or an older adult, consult your doctor to ensure this treatment is safe for your specific situation.
Uses of Amlodipine+perindopril
Medicinal Benefits
Amlodipine+perindopril offers several key benefits that help you manage your cardiovascular health and live a more active life:
- Long-Term Heart Protection: By keeping your blood pressure within a healthy range, this medicine significantly lowers your long-term risk of experiencing a life-threatening stroke or heart attack.
- Improved Exercise Tolerance: By improving blood flow and reducing chest pain, Amlodipine+perindopril helps you engage in daily physical activities and moderate exercise with greater ease and comfort.
- Convenient Dual Action: Because it combines two different blood pressure-lowering agents into a single daily tablet, it simplifies your treatment plan and reduces the number of pills you need to take.
Directions for Use
- Take Amlodipine+perindopril with or without food, or as advised by a doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
- Swallow the medicine as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Amlodipine+perindopril
Common Side Effects (Usually mild):
- Dry, tickling cough
- Dizziness or lightheadedness, especially when standing up
- Swelling in your ankles or feet
- Headache or feeling unusually tired
Serious Side Effects (Consult a doctor right away):
- Swelling of the face, lips, tongue, or throat (signs of a severe allergic reaction)
- Yellowing of the eyes or skin (signs of liver damage)
- Chest tightness, rapid heartbeats, or sudden, severe chest pain
- Severe stomach pain, which can be a sign of an inflamed pancreas
- Significant decrease in how much you urinate, indicating potential kidney problems
Medicines Containing this Salt
View AllDrug Warnings
- Avoid taking Amlodipine+perindopril if you are allergic to any of its components.
- Do not stop taking Amlodipine+perindopril without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems.
- If you have angioedema (Painless swelling under the skin) or diabetes, then inform your doctor immediately.
- If you have kidney disease, you may not use Amlodipine+perindopril with aliskiren (other blood pressure-lowering pills).
- Reduce the amount of table salt (sodium chloride) in your food.
- Avoid foods containing potassium. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood.
- If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Amlodipine+perindopril can be prescribed accordingly.
- Amlodipine+perindopril is not recommended for use in children below 18 yaers of age.
Drug Interactions
- Potassium-sparing diuretics and potassium supplements: May cause dangerously high levels of potassium in your blood, which can affect heart rhythm.
- Nonsteroidal Anti-Inflammatory Drugs (NSAIDs like ibuprofen): Can reduce the blood pressure-lowering effectiveness of Amlodipine+perindopril and increase the risk of kidney damage.
- Other high blood pressure medications or lithium: May lead to excessively low blood pressure or toxic buildup of lithium in the body.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAmlodipine+perindopril interacts with alcohol. Therefore alcohol is not safe.
Pregnancy
unsafeThe use of Amlodipine+perindopril is usually contraindicated during the second and third trimester of pregnancy. It may cause harm to the unborn baby. Hence, you should always consult your doctor before using Amlodipine+perindopril.
Breast Feeding
consult your doctorUse of Amlodipine+perindopril is not recommended during the breastfeeding stage unless recommended by your doctor.
Driving
cautionAmlodipine+perindopril may cause dizziness and sleepiness. Therefore, drive with caution while using Amlodipine+perindopril.
Liver
consult your doctorLet your doctor know if you have any history of liver diseases before using Amlodipine+perindopril.
Kidney
consult your doctorLet your doctor know if you have any history of kidney diseases before using Amlodipine+perindopril.
Children
unsafeAmlodipine+perindopril is not recommended for use in children.
Habit Forming
Diet & Lifestyle Advise
- Watch for Dizziness: To prevent falls or fainting, stand up slowly and carefully from a sitting or lying position, especially when you first start taking Amlodipine+perindopril.
- Avoid Potassium Supplements: Do not take potassium supplements or use salt substitutes containing potassium without consulting your doctor, as this medication can naturally raise potassium levels in your blood.
- Monitor Your Kidney Function: Your doctor may request regular blood tests to monitor your kidney health and electrolyte levels while you are on this medication.
- Check Cold and Cough Medicines: Many over-the-counter decongestants and pain relievers (like ibuprofen) can raise blood pressure; consult your pharmacist before buying them.
- Avoid Grapefruit Products: Grapefruit or grapefruit juice can increase the level of this medicine in your body, raising your risk of experiencing side effects.
Special Advise
- Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
- Amlodipine+perindopril may affect patients with hepatic impairment, so it is used cautiously. Liver function monitoring and tests are advised to track liver enzyme changes.
- Your doctor may advise you to get a regular kidney function test and blood examinations for potassium levels and other electrolytes while using Amlodipine+perindopril to rule out any renal impairment.
- Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril (an antihypertensive drug).
Patients Concern
Disease/Condition Glossary
Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke), and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nosebleeds, vomiting, and chest pain.
FAQs
Amlodipine+perindopril is used to treat hypertension (high blood pressure).
Amlodipine+perindopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.
Amlodipine+perindopril is recommended to use in dose and duration as advised by the doctor. Do not stop taking Amlodipine+perindopril on your own as it may lead to a sudden rise in blood pressure increases the risk of heart attack and stroke.
Amlodipine+perindopril can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.
Amlodipine+perindopril may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Amlodipine+perindopril if you have diabetes.
Even though your blood pressure becomes normal after using Amlodipine+perindopril, it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.
Yes, you can take Amlodipine+perindopril with or without food. However, it is recommended that you take it at the same time each day to maintain consistent blood levels.
Common side effects of Amlodipine+perindopril may include ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.
Amlodipine+perindopril should be avoided during pregnancy as it can harm the unborn baby. It's generally advised to avoid Amlodipine+perindopril while breastfeeding. Consult your doctor for personalized advice.
If you have kidney or liver problems, allergies, or diabetes, inform your doctor before taking Amlodipine+perindopril. Regular monitoring of potassium and blood sugar levels may be necessary.
Store Amlodipine+perindopril in a cool, dry place, away from light and moisture. Keep it out of the reach of children and pets.
It may take a few weeks for the whole blood pressure-lowering effect of Amlodipine+perindopril to be felt. However, some people may notice a difference in blood pressure within a few days.
Yes, Amlodipine+perindopril can cause a dry cough. This is a common side effect, especially in the early stages of treatment. If the cough becomes bothersome, talk to your doctor.
No, you should not stop taking Amlodipine+perindopril suddenly. Doing so can cause a sudden spike in blood pressure. If you must stop taking it, your doctor will gradually reduce your dosage.
Inform your doctor about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Some medicines may interact with Amlodipine+perindopril.
If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and take the scheduled dose. Do not double the dose.
Yes, Amlodipine+perindopril can cause dizziness or lightheadedness, especially when you first start taking it. To minimize this risk, get up slowly from a sitting or lying position.
Yes, Amlodipine+perindopril can cause swelling in the ankles or feet. This is a common side effect that usually goes away on its own. If the swelling is severe or bothersome, talk to your doctor.
Excessive alcohol consumption can lower blood pressure and interact with Amlodipine+perindopril. It's best to avoid or limit your alcohol intake while taking Amlodipine+perindopril.
While Amlodipine+perindopril itself doesn't directly cause weight gain, it can contribute to weight gain by causing swelling or affecting appetite. If you're concerned about weight gain, talk to your doctor.
While rare, Amlodipine+perindopril can cause a rash or skin irritation in some people. Stop taking the medication and contact your doctor immediately if you develop a rash or skin reaction.
In rare cases, Amlodipine+perindopril can cause blurred vision or other eye-light changes. If you experience any vision problems, contact your doctor.
Yes, grapefruit and grapefruit juice can interact with Amlodipine+perindopril, potentially increasing blood levels and leading to side effects. Avoid consuming grapefruit or grapefruit juice while taking this medication.
It's generally safe to take Amlodipine+perindopril with over-the-counter pain relievers like paracetamol or ibuprofen. However, if you have concerns or are taking other medications, do not take them unless prescribed by the doctor.
Amlodipine+perindopril contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor).
Amlodipine+perindopril may cause dizziness and drowsiness. Therefore, drive only if you are alerted after taking the Amlodipine+perindopril.
Caffeine can temporarily raise your blood pressure, which may counteract the benefits of Amlodipine+perindopril. While moderate caffeine intake is generally acceptable for most people, it is best to monitor your blood pressure and discuss your caffeine habits. Talk to your doctor for personalised advice.
It is generally not recommended to take ibuprofen or other NSAID pain relievers with Amlodipine+perindopril. These medicines can reduce the effectiveness of your blood pressure treatment and increase the risk of kidney strain. Talk to your doctor or pharmacist for safe pain relief alternatives.
It is usually recommended to take Amlodipine+perindopril in the morning to help maintain stable blood pressure throughout the day and prevent dizziness during your active hours. However, always take it at the specific time of day recommended by your physician. Talk to your doctor if you want to adjust your schedule.
Author Details
