Azilsartan+chlorthalidone
About Azilsartan+chlorthalidone
Azilsartan+chlorthalidone is a prescription medication used to treat high blood pressure, also known as hypertension. By keeping your blood pressure under control, this medicine helps lower your risk of experiencing serious, life-threatening events such as strokes and heart attacks. It is designed to help individuals whose blood pressure is not fully managed by a single medication alone.
To get the best results, you should take this medicine consistently every day at the same time, with or without food. Making healthy lifestyle choices, such as eating a low-salt diet and exercising regularly, will further support the effectiveness of your treatment. Your doctor will advise you on how to naturally incorporate these changes into your daily routine.
While taking Azilsartan+chlorthalidone, some people may experience mild side effects like dizziness, fatigue, or muscle cramps. However, you must contact your healthcare provider immediately if you experience severe symptoms, such as an irregular heartbeat, sudden swelling, or signs of kidney trouble. Your doctor will monitor your progress to ensure you are tolerating the medication well.
Before you begin taking Azilsartan+chlorthalidone, talk to your doctor if you have a history of kidney disease, liver damage, gout, or diabetes. Do not take this if you are pregnant, as it can cause serious injury or death to an unborn baby. Women who plan to become pregnant should discuss alternative treatment options with their doctor immediately.
This medication can interact with other drugs, alcohol, and tobacco, which can lead to an unsafe drop in your blood pressure or affect how well the medicine works. If you are breastfeeding, elderly, or have underlying health conditions, consult your doctor to ensure this treatment is safe for your specific situation.
Uses of Azilsartan+chlorthalidone
Medicinal Benefits
Azilsartan+chlorthalidone offers reliable, long-term health benefits by helping you keep your blood pressure within a safe, target range. Because high blood pressure rarely has noticeable symptoms, this medicine works quietly in the background to protect your vital organs from strain. Key benefits of taking this medication include:
- Reduced risk of cardiovascular emergencies: Keeping your blood pressure stable, it significantly lowers your chances of having a stroke or a heart attack.
- Organ protection: It helps shield your kidneys, eyes, and brain from the damage that chronic high blood pressure can cause over time.
- Simplified daily routine: Because it combines two active therapies into a single tablet, it reduces the number of pills you need to take each day, making it much easier to stay consistent with your treatment.
Directions for Use
- Azilsartan+chlorthalidone can be taken with or without food. However, taking it with food may help reduce stomach upset.
- It is recommended to take Azilsartan+chlorthalidone once daily or as advised by your doctor.
- Swallow the whole Azilsartan+chlorthalidone with a glass of water.
- Do not crush, chew, or break it.
Storage
Side Effects of Azilsartan+chlorthalidone
Common Side Effects (Usually mild)
- Dizziness or lightheadedness, especially when standing up too quickly
- Feeling unusually tired or weak
- Nausea or a mild upset stomach
- Muscle spasms or cramps
Serious Side Effects (Consult your doctor right away)
- Signs of an allergic reaction, such as a skin rash, itching, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing
- Severe dizziness, spinning sensations, or fainting
- A significant decrease in how often you urinate or how much urine you pass, which may indicate kidney strain
- Signs of electrolyte imbalance, including extreme thirst, a very dry mouth, confusion, a rapid or irregular heartbeat, and severe muscle weakness
Medicines Containing this Salt
View AllDrug Warnings
- Check your tablets: Always inspect your medication before taking it; do not take any tablet that is discoloured, chipped, or crumbling.
- Rise slowly: To prevent sudden dizziness or fainting, take your time when transitioning from a lying or sitting position to standing.
- Monitor your blood pressure: Keep a regular log of your blood pressure readings taken at home and share these with your healthcare provider during your checkups.
- Stay hydrated in the heat: Be extra careful during hot weather or strenuous exercise, as excessive sweating can lead to dehydration and cause your blood pressure to drop too low.
- Avoid self-medicating: Always check with your doctor or pharmacist before starting any new over-the-counter drugs, especially pain relievers, cold remedies, or herbal supplements.
Drug Interactions
Inform your doctor if you are taking any of the following medicines, as they may interact.
- Lithium: Taking Azilsartan+chlorthalidone with lithium can cause lithium to build up to toxic levels in your body.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Pain medicines like ibuprofen or naproxen can reduce the effectiveness of Azilsartan+chlorthalidone and increase your risk of severe kidney damage.
- Potassium supplements or potassium-sparing water pills: Combining these with Azilsartan+chlorthalidone can lead to dangerously high potassium levels in your blood, which can affect your heart rhythm.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAvoid alcohol consumption with Azilsartan+chlorthalidone as it may cause increased dizziness.
Pregnancy
cautionAzilsartan+chlorthalidone is not recommended for use during pregnancy since it may harm the baby. Consult your doctor before taking the Azilsartan+chlorthalidone if you plan to become pregnant or are already pregnant.
Breast Feeding
cautionPlease consult your doctor before taking Azilsartan+chlorthalidone if you are breastfeeding. Your doctor will decide if Azilsartan+chlorthalidone can be taken during lactation or not.
Driving
cautionAzilsartan+chlorthalidone may cause side effects like dizziness or tiredness. Hence, it is recommended not to drive or operate machinery until you are alert.
Liver
cautionLet your doctor know if you have/had the liver disease before taking Azilsartan+chlorthalidone. Your doctor may adjust the dose accordingly.
Kidney
cautionLet your doctor know if you have/had kidney disease before taking the Azilsartan+chlorthalidone. Your doctor may adjust the dose accordingly.
Children
unsafeSafety and efficacy of Azilsartan+chlorthalidone have not been established in children.
Habit Forming
Diet & Lifestyle Advise
Making healthy lifestyle choices can greatly enhance the effectiveness of Azilsartan+chlorthalidone in lowering your blood pressure. Try implementing the following evidence-based habits:
- Reduce sodium intake: Limit the amount of salt in your diet by avoiding processed foods and not adding extra salt to your meals, as sodium causes your body to retain fluid and raises blood pressure.
- Eat a heart-healthy diet: Focus on meals rich in fresh vegetables, fruits, whole grains, and lean proteins while minimising saturated fats and cholesterol.
- Stay active: Engage in regular, moderate exercise, such as brisk walking, swimming, or cycling, for at least 30 minutes a day on most days of the week, as approved by your doctor.
- Limit alcohol consumption: Keep your alcohol intake to a minimum, as alcohol can interact with your medication to cause sudden, unsafe drops in your blood pressure.
- Avoid tobacco: Quit smoking and avoid secondhand smoke, as nicotine damages blood vessels and accelerates heart disease.
Special Advise
Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor.
Thiazide diuretics like Chlorthalidone may increase serum triglyceride and cholesterol levels. Hence it is advised to monitor your cholesterol levels regularly.
Chlorthalidone in Azilsartan+chlorthalidone may interfere with specific lab tests like parathyroid and protein-bound iodide tests; hence, inform the person doing the tests that you are taking Azilsartan+chlorthalidone.
Your doctor may advise you to get a regular kidney function test and blood examinations for potassium levels and other electrolytes while using Azilsartan+chlorthalidone to rule out any renal impairment.
Regular monitoring of blood glucose levels is advised in diabetic patients while using Azilsartan+chlorthalidone.
Patients Concern
Disease/Condition Glossary
Hypertension: Hypertension is a medical condition in which blood pressure is elevated persistently in the arteries. It is considered an essential risk factor for cardiovascular diseases and can be caused due to obesity, diabetes, smoking, high salt intake, stress, lack of physical activity or ageing. Blood pressure is measured in the ratio of systolic pressure to diastolic pressure. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. The ideal blood pressure range lies between 90/60 mmHg and 120/80 mmHg. It is considered high blood pressure if the blood pressure is 140/90 mmHg or greater.
FAQs
Azilsartan+chlorthalidone is used to treat high blood pressure (hypertension).
Azilsartan+chlorthalidone works by relaxing and widening the blood vessels. It also prevents fluid retention due to excess salt build-up. This helps the heart pump blood easily throughout the body, lowering blood pressure.
Azilsartan+chlorthalidone can cause high levels of potassium in the blood leading to hyperkalaemia. Hence it is not recommended to use potassium supplements along with Azilsartan+chlorthalidone. However, consult your doctor if you are already taking other medicines before starting Azilsartan+chlorthalidone.
Chlorthalidone in Azilsartan+chlorthalidone may affect blood sugar levels in people with diabetes. Hence, it is advised to regularly monitor your sugar levels while taking Azilsartan+chlorthalidone. Your doctor may adjust the dose accordingly. Please seek medical advice for more information before starting Azilsartan+chlorthalidone.
Even though your blood pressure becomes normal after using Azilsartan+chlorthalidone, it may switch back to high ranges if you stop using it. Therefore, continue taking Azilsartan+chlorthalidone for as long as your doctor has advised.
Consult your doctor before taking Azilsartan+chlorthalidone with other medicines as Azilsartan+chlorthalidone may increase the rate of gastrointestinal transit, which may affect the absorption of other orally administered medicines taken simultaneously.
Azilsartan+chlorthalidone may cause side effects like nausea, taste changes, stomach upset, diarrhoea, headache, weakness, dizziness, and decreased blood pressure. Most of these side effects of Azilsartan+chlorthalidone do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.
Azilsartan+chlorthalidone may cause dizziness as a side effect. Avoid driving or operating machinery if you experience dizziness.
No, Azilsartan+chlorthalidone is not a blood thinner. It is an anti-hypertensive medicine.
Azilsartan+chlorthalidone is a combination medicine. It contains a diuretic (Chlorthalidone) and angiotensin receptor blocker (Azilsartan).
Contact your doctor immediately if you think you may be pregnant. Do not stop the medication without medical guidance, as sudden discontinuation can raise blood pressure dangerously. This medication can cause severe harm, birth defects, or death to an unborn baby. If you suspect you are pregnant. Breastfeeding mothers are advised to discuss risks with their doctor before continuing this medication.
Yes, because Azilsartan+chlorthalidone contains a water pill, it increases your fluid loss through urine. If you do not drink enough fluids, you can experience dehydration or electrolyte imbalances. Talk to your doctor if you experience extreme thirst, dry mouth, or severe fatigue.
You should avoid taking pain relievers like ibuprofen or naproxen without consulting your doctor first. These medicines can decrease the effectiveness of Azilsartan+chlorthalidone and increase the risk of kidney damage. Talk to your doctor for safer alternatives.
Yes, your doctor will likely schedule regular blood tests to check your kidney function and monitor your electrolyte levels, such as potassium and sodium. This ensures the medicine is working safely for you. Talk to your doctor about your monitoring schedule.
It is highly recommended to limit or avoid alcohol. Alcohol can compound the blood pressure-lowering effect of the medicine, making you severely dizzy, lightheaded, or prone to fainting. Talk to your doctor for personalised advice.

