Cilgavimab+tixagevimab
About Cilgavimab+tixagevimab
Cilgavimab+tixagevimab (Evusheld) was previously authorized in several countries to help prevent COVID-19 in certain high-risk individuals. However, in January 2023, the U.S. Food and Drug Administration (FDA) revoked its Emergency Use Authorization (EUA) after laboratory studies showed that the medicine was not expected to provide adequate protection against the dominant XBB-lineage and related Omicron variants. The regulatory status and availability of this medicine may differ between countries and may change as new variants emerge. Always consult your doctor and verify the latest local guidance before considering this treatment.
Cilgavimab+tixagevimab is a preventive injection designed to help reduce the risk of COVID-19 before exposure to the virus.It was developed for adults and adolescents with weakened immune systems who may not develop enough protection from COVID-19 vaccines, or for certain people who cannot receive vaccination. It is administered by a healthcare professional as two injections during the same visit.
Since this is a preventive option, it is given as a single treatment of two consecutive injections. A healthcare provider will inject it directly into your muscle, meaning you do not need to worry about taking it with or without food. Eating a nutrient-rich diet, staying hydrated, and managing stress can further support your immune health while using this medicine.
Most people tolerate these injections well, though you might experience mild side effects like pain or bruising where you were injected. If you experience serious side effects, such as breathing difficulties, chest pain, or a rapid heart rate, you must contact your doctor or seek emergency medical care immediately.
Do not take this if you have a history of severe allergic reactions to any of the ingredients in this medicine. Before starting, tell your doctor if you have a history of bleeding disorders, low blood platelets, or heart problems, as these conditions require careful evaluation. Your doctor will help decide if this option is safe for you.
This medicine can be given without regard to meals, as food does not significantly affect how it works.Alcohol and smoking are not known to directly interact with this medicine. However, they can affect your overall health and immune function. Talk to your doctor about your alcohol intake or smoking habits so they can provide advice that is appropriate for your health. If you are pregnant, breastfeeding, or planning to become pregnant, talk to your doctor or pharmacist to weigh the benefits and risks before receiving this injection.
Uses of Cilgavimab+tixagevimab
Medicinal Benefits
In clinical studies conducted before newer COVID-19 variants became widespread, Cilgavimab+tixagevimab demonstrated the following benefits when used as prescribed:
- Rapid Protection: Cilgavimab+tixagevimab provides ready-made antibodies that begin offering protection soon after administration. The medicine starts working soon after it is given, helping your body block the virus if you are exposed.This can be especially helpful for people whose immune systems may not produce enough antibodies after vaccination.
- High Risk Protection: By providing a defense barrier, this medicine offers peace of mind for high-risk individuals, such as cancer patients or organ transplant recipients, allowing them to navigate daily life with less anxiety about severe illness.
- Single Dose Protection: Clinical studies conducted before newer COVID-19 variants became widespread showed protection lasting for approximately 6 months. However, the actual duration and effectiveness may vary depending on the circulating variants and current medical recommendations.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication, to improve effectiveness.
- Cilgavimab+tixagevimab will be administered by a healthcare professional.
- Do not self-administer it.
Storage
Side Effects of Cilgavimab+tixagevimab
Common Side Effects (Usually mild):
- Pain, redness, or swelling at the injection site
- Headache
- Fatigue or feeling tired
- Mild muscle or joint pain
Serious Side Effects (Consult your doctor right away):
- Signs of a severe allergic reaction (such as hives, swelling of the face, lips, or throat, and difficulty breathing)
- Chest pain, pressure, or shortness of breath
- Dizziness, fainting, or sudden weakness
- Unusual bruising or bleeding at the injection site
Drug Warnings
- Check Solution: Confirm with your healthcare provider that the solution is clear to slightly yellow and free of particles before they inject it.
- Two Injection Sites: Ensure the injections are given into two different muscles (typically one in each buttock cheek) during your appointment.
- Post-Injection Monitoring: Sit or lie down during the injection and remain under medical observation for at least 60 minutes afterward to ensure your safety.
- Inform About Blood Thinners: If you are taking blood thinners, inform the nurse or doctor before the injection, as muscle injections can cause bruising or bleeding.
- Consult Before COVID-19 Vaccine: Do not receive any COVID-19 vaccine within a specific window of time before or after this injection without consulting your doctor first.
Drug Interactions
Some medicines may affect how Cilgavimab+tixagevimab works or increase the risk of side effects:
- If you are planning to receive a COVID-19 vaccine, tell your doctor before receiving Cilgavimab+tixagevimab. Your healthcare provider may recommend spacing the vaccine and this medicine by an appropriate interval based on the latest medical guidance to help ensure the best possible protection.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is not recommended to consume alcohol with Cilgavimab+tixagevimab. Please consult your doctor if you have any concerns.
Pregnancy
cautionNot enough studies exist to ascertain the effect of Cilgavimab+tixagevimab on pregnancy. Please consult your doctor if you have any concerns.
Breast Feeding
cautionNot enough studies exist to ascertain the effect of Cilgavimab+tixagevimab on nursing. Please consult your doctor in case of any concerns.
Driving
cautionIt is not known if Cilgavimab+tixagevimab affects your ability to drive. Drive only if you are alert.
Liver
cautionExercise caution before using Cilgavimab+tixagevimab in case of established liver disease. Please consult your doctor to address any concerns.
Kidney
cautionExercise caution before using Cilgavimab+tixagevimab in case of established kidney disease. Please consult your doctor to address any concerns.
Children
unsafeCilgavimab+tixagevimab is not recommended for children below 12years and those weighing below 40kgs. Please consult your doctor in case of any concerns.
Habit Forming
Diet & Lifestyle Advise
- Healthy Diet: Eat a balanced, nutrient-dense diet rich in vitamins C and D, and zinc, to support your body's natural defense mechanisms.
- Stay Hydrated: Stay adequately hydrated by drinking plenty of water, which helps your body process medications and maintains healthy tissue functions.
- Practice Hygiene: Avoid crowded places and continue practicing basic hygiene, like washing your hands frequently, especially if you are severely immunocompromised.
- Regular Exercise: Get regular, gentle exercise as approved by your doctor to keep your circulation active and support your overall well-being.
- Quality Sleep: Prioritize quality sleep of 7–9 hours per night to help your immune system function at its best.
Special Advise
In case of a fever or rash following Cilgavimab+tixagevimab, do not use any antipyretic or anti-allergic medicines without consulting the doctor.
Patients Concern
Disease/Condition Glossary
Coronavirus Disease: Coronavirus disease is an infection caused by the SARS-CoV-2 virus. Coronavirus belongs to a group of RNA viruses and has crown-like projections on the surface of the pathogen. The virus transmits through droplets generated from an infectious person’s cough, sneeze or heavy breathing. The common symptoms of coronavirus disease are dry cough, tiredness, breathlessness, fever, loss of sense of taste and smell, diarrhoea, body pains, headache, and sore throat.
FAQs
Cilgavimab+tixagevimab belongs to the group of monoclonal antibodies used in the prevention of COVID-19 in people older than 12 years and weighing at least 40kgs, who are not currently infected and have not been infected with COVID-19 in the past. It is used in individuals who are immunocompromised or are unable to receive the COVID-19 vaccine due to allergy to the vaccine.
Cilgavimab+tixagevimab works by inducing an antibody response in the body by instilling monoclonal antibodies that mimic the natural defences of the body.
Cilgavimab+tixagevimab is found to be effective in preventing covid for at least 6 months.
Only an RT-PCR test can determine whether or not you have COVID. While a loss of smell has been noted as a common symptom, the new variant does not cause a loss of smell.
Not enough literature exists to ascertain the effects of Cilgavimab+tixagevimab on fertility. Please consult your doctor in case of any concerns.
Vaccines stimulate the body to make its own antibodies against infection. On the other hand, monoclonal antibodies deliver lab-made antibodies against the virus.
Remdesivir is an antiviral that functions to kill the virus. On the other hand, Cilgavimab+tixagevimab augments the body’s natural immunity against the virus by attaching to its structure. Thereby, prevents infection.
Whether you can receive Cilgavimab+tixagevimab depends on the currently circulating COVID-19 variants, local regulatory approval, and your individual medical condition. In some countries, including the United States, this medicine is no longer authorized because it is not expected to protect against certain newer variants. If it is available in your region, your doctor will determine whether it is appropriate for you, particularly if you have a weakened immune system or cannot receive certain COVID-19 vaccines.
This medicine is given as two separate, consecutive intramuscular injections, typically in the buttocks, administered by a healthcare professional in a medical setting. Talk to your doctor if you have concerns about the injection process.
No, Cilgavimab+tixagevimab is designed for prevention and is not used to treat active COVID-19 infections. If you test positive, talk to your doctor about appropriate treatment options.
There is limited data on the use of this medicine during pregnancy or breastfeeding. Talk to your doctor or pharmacist to understand the potential benefits and risks for you and your baby.
The most common side effects include soreness, redness, or swelling at the injection site, headache, and fatigue. These are usually mild and resolve on their own. Talk to your doctor if they persist.
While Cilgavimab+tixagevimab provides significant protection, no preventative treatment is 100% effective. If you are highly immunocompromised, talk to your doctor about whether you should continue wearing a mask in crowded or indoor settings.
