Dutasteride+silodosin
About Dutasteride+silodosin
Dutasteride+silodosin is a combination prescription medication used to treat the symptoms of an enlarged prostate, a condition medically known as benign prostatic hyperplasia (BPH). It helps relieve uncomfortable urinary symptoms such as a weak stream, straining, and the frequent or urgent need to urinate. This treatment is specifically formulated for men experiencing prostate gland enlargement.
To achieve the best results, you must take this medicine consistently every day as prescribed by your doctor. It should be taken with a meal, preferably at the same time each day, to help your body absorb the medicine properly. Incorporating lifestyle changes, such as limiting your fluid intake before bed and reducing caffeine, can further support the effectiveness of this treatment.
While taking Dutasteride+silodosin, you may experience mild side effects, such as a runny nose or changes in ejaculation. However, you must contact your doctor right away if you experience serious symptoms, such as severe dizziness, fainting, or signs of a severe allergic reaction. Your pharmacist or doctor can guide you on what to expect during your treatment.
Do not take this if you are a woman, a child, or if you have severe kidney or liver damage. It is also important to avoid this medication if you have a known allergy to any of its ingredients. Always talk to your doctor or pharmacist to ensure this medicine is safe for your specific health conditions before starting.
This medication can interact with other drugs, especially blood pressure medicines, which may increase the risk of dizziness. Pregnant women, or those who may become pregnant, must never handle these tablets because the active ingredients can be absorbed through the skin and cause harm to a male fetus. Elderly patients should also take extra care, as they may be more prone to dizziness and falls while taking this medication
Uses of Dutasteride+silodosin
• Treatment of Benign Prostatic Hyperplasia (BPH): Dutasteride+silodosin helps reduce prostate size by blocking the production of hormones responsible for its growth and also improves urinary flow and reduces symptoms like difficulty urinating, frequent urges, and weak urine stream.
• Relaxation of Bladder and Prostate Muscles: Dutasteride+silodosin works by relaxing the muscles in the bladder and prostate, making urination easier and helps relieve urinary discomfort associated with an enlarged prostate.
• Prevention of Urinary Blockage: Dutasteride+silodosin reduces the risk of complete urinary obstruction, which can occur if BPH is left untreated and helps maintain normal urinary function over time.
Medicinal Benefits
Dutasteride+silodosin helps relieve urinary symptoms caused by an enlarged prostate (benign prostatic hyperplasia). This combination works to improve urine flow while also addressing the underlying enlargement of the prostate.
- Improves Urine Flow: Helps relax the muscles around the prostate and bladder, making urination easier and improving urinary stream strength.
- Reduces Urinary Symptoms: Helps relieve symptoms such as difficulty starting urination, weak urine flow, frequent urination, and the feeling of incomplete bladder emptying.
- Decreases Night-Time Urination: May reduce the need to wake up frequently at night to pass urine, supporting better sleep quality.
- Helps Shrink the Prostate: DUTASTERIDE gradually reduces prostate size, helping address the underlying cause of symptoms.
- Reduces the Risk of Complications: Long-term treatment may lower the risk of acute urinary retention and reduce the likelihood of requiring prostate surgery.
Directions for Use
Follow these step-by-step instructions to take this medication safely and effectively:
- Swallow the tablet whole with a full glass of water.
- Do not crush, chew, or break the tablet, as this can destroy the protective coating and irritate your mouth or throat.
- Take the tablet with a meal, preferably at the same time every day, to ensure proper absorption and to reduce the risk of dizziness.
- Always follow your doctor's exact instructions regarding your treatment plan. Do not stop taking this medication suddenly without consulting your healthcare provider first.
Storage
Side Effects of Dutasteride+silodosin
Common Side Effects (Usually mild)
- Reduced amount of semen released during sex (retrograde ejaculation)
- Dizziness or lightheadedness, especially when standing up
- Runny or stuffy nose
- Diarrhoea or mild upset stomach
Serious Side Effects (Consult your doctor right away)
- Severe dizziness, spinning sensations, or fainting
- Signs of a serious allergic reaction, such as skin rash, itching, hives, or swelling of the face, lips, tongue, or throat
- A painful erection that lasts for 4 hours or longer (priapism)
- Breast changes, including breast enlargement, tenderness, or nipple discharge
Medicines Containing this Salt
View All
Drug Warnings
- Inform Your Eye Surgeon: Tell your eye specialist if you are taking this medicine before cataract or glaucoma surgery, as it may affect the procedure.
- Stand Up Slowly: Rise gradually from sitting or lying positions to help prevent dizziness and reduce the risk of falls.
- Avoid Handling During Pregnancy: Pregnant women or women who may become pregnant should not handle broken or crushed tablets because the medicine may be absorbed through the skin.
- Do Not Donate Blood: Avoid donating blood while taking Dutasteride+silodosin and for at least 6 months after stopping treatment.
- Use Appropriate Contraception: Use a barrier contraceptive if your partner is pregnant or may become pregnant, as small amounts of the medicine may be present in semen.
Drug Interactions
Drug-Drug Interactions
Inform your doctor if you are taking any of the following medicines, as they may interact with Dutasteride+silodosin:
- Blood pressure medicines or other alpha-blockers: May increase the risk of severely low blood pressure and extreme dizziness upon standing.
- Erectile dysfunction medicines (such as sildenafil or tadalafil): Can cause a dangerous drop in blood pressure when taken together with this medication.
- Strong CYP3A4 inhibitors (such as ketoconazole, ritonavir, or clarithromycin): May increase the concentration of the medicine in your body, raising the risk of severe side effects.
Drug-Food Interactions
Certain foods and beverages may affect how Dutasteride+silodosin works or increase the likelihood of side effects:
- Grapefruit and grapefruit juice: May interfere with how your body breaks down the medication, potentially increasing its level in your bloodstream and causing side effects.
Drug-Disease Interactions
Inform your doctor if you have any of the following medical conditions before taking Dutasteride+silodosin, as dose adjustments or additional monitoring may be required:
- Severe liver damage: May cause the medicine to build up in your body, increasing the risk of side effects.
- Severe kidney damage: Can affect how the medicine is cleared from your body, requiring caution or dose adjustments.
- Low blood pressure (hypotension): May worsen your symptoms of dizziness, lightheadedness, or fainting.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are advised not to consume alcohol while taking Dutasteride+silodosin as it makes you pee more and can irritate your bladder and also increased dizziness and lower blood pressure.
Pregnancy
not applicableWomen should not use Dutasteride+silodosin as it is used to treat benign prostatic hyperplasia (BPH) in men only.
Breast Feeding
not applicableWomen should not use Dutasteride+silodosin as it is used to treat benign prostatic hyperplasia (BPH) in men only.
Driving
unsafeDutasteride+silodosin may cause dizziness. Therefore you are advised to drive and operate machinery only if you are alert.
Liver
cautionDutasteride+silodosin should be used with caution in patients with liver disease. The dose adjustment may be needed in such patients.
Kidney
cautionDutasteride+silodosin should be used with caution in patients with kidney disease. The dose adjustment may be needed in such patients.
Children
unsafeDutasteride+silodosin is not recommended for children below 18 years of age as the safety and efficacy are not established.
Habit Forming
Diet & Lifestyle Advise
- Limit Evening Fluid Intake: Reduce fluid consumption 2 to 4 hours before bedtime to help minimise night-time urination.
- Avoid Bladder Irritants: Limit caffeine and alcohol, as they may worsen urinary frequency and urgency.
- Practice Double Voiding: After urinating, wait briefly and try to urinate again to help empty the bladder more completely.
- Stay Physically Active: Regular moderate exercise may help improve urinary symptoms associated with an enlarged prostate.
- Be Careful with Cold Medicines: Consult your doctor or pharmacist before using decongestants or other cold remedies, as they may worsen urinary difficulties.
Special Advise
Regularly monitor blood pressure is required while taking Dutasteride+silodosin.
Patients Concern
Disease/Condition Glossary
Benign Prostatic Hyperplasia (BPH): is an enlargement of the prostate gland. The prostate is a small, muscular gland in the male reproductive system. It is a common condition as men get older (50-60 years). It occurs when the cells of the prostate gland begin to multiply. In an enlarged prostate gland, the bladder wall becomes thicker, and the bladder may weaken and lose the ability to empty fully, leaving some urine in the bladder. Symptoms of BPH include frequent or urgent need to urinate, nocturia (increased frequency of urination at night, difficulty starting urination, inability to empty the bladder, painful urination, blood in the urine.
FAQs
Dutasteride+silodosin is used to treat the symptoms of Benign Prostatic Hyperplasia (BPH) in men.
No, Dutasteride+silodosin should not be taken along with blood-pressure-lowering medicines. Dutasteride+silodosin may cause a sudden drop in your blood pressure which could lead to dizziness or fainting. Therefore, if Dutasteride+silodosin is taken along with blood pressure lowering medicines, it could lead to a severe decrease in blood pressure which could be lethal.
Yes, Dutasteride+silodosin may cause dizziness. You are advised not to drive or operate heavy machinery after taking Dutasteride+silodosin as it may cause dizziness. Drive or operate machinery only if you are alert.
Dutasteride+silodosin is a combination of two drugs, namely; Silodosin and Dutasteride used to treat the symptoms of benign prostatic hyperplasia (BPH) in adults with an enlarged prostate gland. Silodosin belongs to a class of alpha-1 receptors (located in prostate and bladder) blocker that works by blocking the action of alpha-1 receptors and causes smooth muscle relaxation in the bladder and prostate. Dutasteride belongs to a class of 5-alpha reductase that works by blocking the action of a 5-alpha reductase enzyme, resulting in a shrink of the size of the prostate gland. Dutasteride+silodosin reduces the BPH symptoms and improves your ability to urinate.
The side effects of Dutasteride+silodosin include dizziness, headache, diarrhoea, nasal congestion (stuffy nose), impotence (erectile dysfunction) and ejaculation disorder. If these side effects persist or worsen, please consult your doctor.
You should take Dutasteride+silodosin for as long as it is prescribed by your doctor. It is usually advised for long term use. If you discontinue Dutasteride+silodosin in the midway, it may worsen your condition.
Take Dutasteride+silodosin as advised by your doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it. Take it at the same time every day. Do not miss doses or stop the treatment before the prescribed duration, even if you feel well.
Dutasteride+silodosin is effective if used in the dose and duration prescribed by your doctor. Even if you see improvement in your condition, do not stop using Dutasteride+silodosin too early as the symptoms may return or worsen.
Benign prostatic hyperplasia (BPH) also known as prostate gland enlargement is a common condition in older men. The symptoms include urgent or frequent need to urinate, inability to completely empty the bladder and increased frequency of urination at night (nocturia).
The use of Dutasteride+silodosin is contraindicated in patients who are allergic to any ingredients of it. Dutasteride+silodosin should be used with caution in patients with underlying liver or kidney disease. If you have any concerns, consult your doctor.
Store Dutasteride+silodosin in a cool, dry and dark place. Keep it out of reach of children.
Dutasteride+silodosin is safe if used in the dose and duration prescribed by your doctor. Take it exactly as advised and do not miss any dose. Follow your doctor's instructions carefully and if any of the side effects bother you, inform your doctor.
It is best to take Dutasteride+silodosin after meals. Swallow it as whole with water. Do not open, chew or crush it. Follow your doctor’s instructions carefully.
You may notice an improvement in your urinary flow within a few days due to the muscle-relaxing effect. However, it can take several weeks or even months for the prostate-shrinking effect to become fully noticeable. Talk to your doctor if your symptoms do not improve after a few weeks.
o, Dutasteride+silodosin is prescribed only for men with an enlarged prostate. Women, especially those who are pregnant or may become pregnant, must not take this medication or handle the tablets, as it can cause serious developmental issues in a male fetus.
The medicine remains in your blood for a long time. If a pregnant woman receives your donated blood, the active ingredients could cause birth defects in her developing male baby. You must wait at least 6 months after stopping the medicine before donating blood.
Yes, this medication can cause sexual side effects, such as reduced semen during ejaculation (retrograde ejaculation) or difficulty maintaining an erection. These effects are usually temporary and stop after the medication is discontinued. Talk to your doctor if you have concerns.
It is best to limit or avoid alcohol while taking this medicine. Alcohol can worsen dizziness and lightheadedness caused by the medication and can also irritate your bladder, worsening your urinary symptoms. Talk to your doctor for personalised advice.
If you feel dizzy or lightheaded, sit or lie down immediately until the feeling passes. To prevent this, avoid standing up too quickly from a sitting or lying position. If dizziness persists or causes fainting, contact your doctor right away.
Do not stop taking your medication without consulting your doctor. However, you must inform your eye surgeon well in advance of any cataract or glaucoma surgery that you are taking Dutasteride+silodosin, as it can affect your pupils during the procedure.
You should take Dutasteride+silodosin with a meal, preferably at the same time every day. Taking it with food helps your body absorb the medication properly and reduces the risk of side effects like dizziness. Talk to your doctor or pharmacist if you have trouble taking it with food.
