Eribulin Mesylate
About Eribulin Mesylate
Eribulin Mesylate belongs to a group of medicines known as 'anti-cancer' used to treat various cancers, including breast and liposarcoma. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. Breast cancer is cancer that forms in the cells of the breasts. A liposarcoma is a rare cancer that develops in your fatty tissue.
Eribulin Mesylate contains Eribulin, which works by stopping the cancer cells from separating into two new cells. So, it blocks the growth of the cancer.
Eribulin Mesylate should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions that occur while on therapy are neutropenia (lower-than-normal levels of neutrophils), anaemia (lack of blood), asthenia (weakness), fatigue(tiredness), alopecia (hair loss), peripheral neuropathy (Weakness, numbness, and pain from nerve damage), nausea, and constipation. Most of these side effects of Eribulin Mesylate do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
To treat your condition effectually, continue taking Eribulin Mesylate for as long as your doctor has prescribed. Do not stop using the Eribulin Mesylate midway. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Eribulin Mesylate should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Eribulin Mesylate in patients with hepatic, renal, heart dysfunction and or Neutropenia (Lower-than-normal levels of neutrophils), so inform your doctor about all your medical conditions and medications you are currently taking.
Uses of Eribulin Mesylate
Medicinal Benefits
Eribulin Mesylate helps treat certain advanced cancers by slowing the growth and spread of cancer cells. With regular use as prescribed, it helps control disease progression, relieve cancer-related symptoms, and support improved treatment outcomes.
- Helps Control Cancer Progression: By targeting rapidly dividing cancer cells, this medicine helps slow the growth and spread of advanced cancers, supporting effective disease management.
- Relieves Tumour-Related Symptoms: As tumour growth is controlled, this medicine may help reduce pain, pressure, and other symptoms caused by the cancer, improving daily comfort.
- Supports Better Quality of Life: By helping stabilise the disease, this medicine may improve physical functioning, maintain daily activities, and support overall well-being throughout treatment.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication.
- Eribulin Mesylate will be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.
- Do not self-administer.
Storage
Side Effects of Eribulin Mesylate
Common Side Effects (Usually mild):
- Nausea and loss of appetite
- Feeling very tired or weak
- Hair loss
- Numbness, tingling, or a burning sensation in the hands or feet
Serious Side Effects (Consult a doctor right away):
- Fever, chills, sore throat, or other signs of infection
- Extreme shortness of breath or chest pain
- Severe muscle weakness or unusual pain
- Signs of an allergic reaction, such as swelling of the face, lips, or throat, or a severe skin rash
Medicines Containing this Salt
View AllDrug Warnings
- Check the Liquid: Ensure the healthcare provider inspects the vial before use; the liquid should be clear and colourless, without any visible particles.
- Report Nerve Tingling Early: Let your healthcare team know immediately if you start feeling numbness or tingling in your fingers or toes, as this may require a change in your treatment schedule.
- Watch the Injection Site: Tell your nurse right away if you feel burning, pain, or swelling at the injection site during the injection.
- Monitor Your Temperature: Keep a reliable thermometer at home and check your temperature if you feel warm or unwell; a fever can be a medical emergency during this treatment.
- Avoid Pregnancy: Use effective birth control during treatment and for at least several months after your last dose to prevent pregnancy.
Drug Interactions
- Certain prescription medicines that affect liver enzymes may alter how Eribulin Mesylate is cleared from your body, which could increase side effects. Always share a complete list of your current medications with your doctor.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid alcohol consumption while on treatment with Eribulin Mesylate.
Pregnancy
unsafeEribulin Mesylate should not be used during pregnancy because it can harm your fetus (newborn baby).
Breast Feeding
unsafeDo not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.
Driving
cautionEribulin Mesylate may cause side effects such as tiredness and dizziness. Do not drive or use machines if you feel tired or dizzy.
Liver
cautionA lower starting dose is recommended for patients with mild (Child-Pugh A) and moderate (ChildPugh B) liver impairment. There is no information available on patients with severe liver impairment.
Kidney
cautionA lower starting dose is recommended for patients with moderate (CrCl 30-50 mL/min) kidney impairment. There is no information available on patients with severe kidney impairment.
Children
unsafeDo not use this medicine for children between 0 to 18 years old.
Habit Forming
Diet & Lifestyle Advise
- Stay Hydrated: Drink plenty of water and clear fluids throughout the day to help your kidneys flush out the medicine and prevent dehydration.
- Prevent Infections: Wash your hands frequently and avoid close contact with people who are sick, as this medicine can temporarily lower your white blood cell count.
- Manage Fatigue: Balance light physical activity, like short walks, with plenty of rest to help manage treatment-related tiredness.
- Eat Small, Frequent Meals: If you experience nausea or loss of appetite, eating small portions throughout the day can be easier on your stomach than three large meals.
- Protect Your Skin and Nails: Use gentle, fragrance-free moisturisers and avoid harsh chemicals to protect your skin and nails, which may become dry or brittle during treatment.
Special Advise
- Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Eribulin Mesylate.
- Eribulin Mesylate should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Eribulin Mesylate.
- Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
- Peripheral blood counts should be frequently monitored during Eribulin Mesylate treatment and, when appropriate, until recovery is achieved.
- Do not donate sperm during treatment with Eribulin Mesylate and for three months after your last dose.
Patients Concern
Disease/Condition Glossary
Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.
Breast cancer: It is a type of cancer that develops in breast cells stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other body parts. Symptoms of breast cancer include a lump in the breast or tissue thickening, which feels different than the normal surrounding tissues, breast pain, redness, swelling, and nipple discharge other than breast milk.
Liposarcoma: Liposarcoma is a rare tumour derived from fat tissue that occurs in the “soft tissues” of the body (soft tissue sarcoma). It is classified as a cancer (malignant) because of its potential to recur locally and spread to other areas of the body. The severity of the disease depends on the subtype of the liposarcoma and the presenting stage of the primary tumour. It can arise in various locations throughout the body, although it is most frequently found in the extremities, particularly in the thigh.
FAQs
Eribulin Mesylate is administered as an intravenous (IV) injection directly into a vein by a doctor or nurse in a clinic or hospital. The injection usually takes 2 to 5 minutes. Do not self-administer this medicine. Talk to your doctor for more information.
Yes. Hair loss (alopecia) is a common side effect of Eribulin Mesylate. It is usually temporary, and hair typically begins to grow back after treatment is completed. However, the amount and timing of regrowth can vary between individuals. Speak with your doctor if you have concerns.
Yes. Eribulin Mesylate can lower blood cell counts, especially neutrophils (a type of white blood cell that helps fight infection). It may also reduce red blood cells, leading to anaemia. Your doctor will monitor your blood counts regularly and adjust your treatment if needed.
Some patients feel very tired or dizzy after treatment. It is best to see how the medicine affects you first, or arrange for someone else to drive you home after your appointment. Talk to your doctor.
Seek medical attention immediately. A fever can be a sign of a serious infection, which requires prompt treatment because this medicine can lower your white blood cell count. Talk to your doctor.
Some supplements may interfere with how this medicine works in your body. Always discuss any vitamins, herbal products, or over-the-counter remedies with your healthcare team before using them. Talk to your doctor.
While Eribulin Mesylate is not a cure, it is highly effective at slowing down the growth and spread of advanced cancer cells, helping to manage the disease and extend survival. Talk to your doctor.
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