Histamine+human Normal Immunoglobulin+sodium Thiosulphate
About Histamine+human Normal Immunoglobulin+sodium Thiosulphate
Histamine+human Normal Immunoglobulin+sodium Thiosulphate is a specialised injection therapy approved in India by the CDSCO based primarily on regional post-marketing data to manage long-term allergic conditions like allergic asthma, allergic rhinitis (hay fever), and chronic hives (urticaria). Its clinical evidence base does not meet the rigorous trial thresholds required for approval by major global regulatory bodies such as the US FDA or European Medicines Agency (EMA), nor is it recognised in international guidelines like GINA or ARIA. Unlike standard allergy shots or drops—such as Subcutaneous Immunotherapy (SCIT) or Sublingual Immunotherapy (SLIT), which build targeted tolerance to specific triggers like pollen—this combination acts as a broad, non-specific immune-calming (immunomodulating) treatment used within local medical frameworks.
Because Histamine+human Normal Immunoglobulin+sodium Thiosulphate is administered as an injection, your doctor will determine the frequency and consistency of your dosing schedule, which is typically given in a series of cycles. This medicine does not depend on food intake, so you do not need to worry about taking it with or without meals. Making practical lifestyle adjustments, such as using allergen-proof bedding and keeping indoor air clean, can significantly improve your treatment outcomes.
Like most medical therapies, Histamine+human Normal Immunoglobulin+sodium Thiosulphate may cause some mild side effects, which commonly include pain or redness at the injection site, mild headaches, or a temporary low-grade fever. If you experience severe symptoms, such as difficulty breathing or signs of a severe allergic reaction, you must consult your doctor immediately.
Before beginning your treatment, always inform your healthcare provider about your complete medical history. Do not take this if you have a known history of severe allergic reactions to human blood products or immunoglobulins. Your doctor will carefully evaluate your condition to ensure this treatment is safe for you.
It is also vital to discuss any other medicines, supplements, or vaccines you have recently received, as certain treatments can interfere with how this medicine works. Additionally, if you are pregnant, breastfeeding, or managing health conditions as an elderly individual, consult your doctor to discuss specific safety measures before starting your injections.
Uses of Histamine+human Normal Immunoglobulin+sodium Thiosulphate
Medicinal Benefits
Histamine+human Normal Immunoglobulin+sodium Thiosulphate may offer several potential benefits in managing chronic allergic conditions, as observed in some patients under specialist care:
- Long-Term Allergy Relief: The intended benefit of Histamine+human Normal Immunoglobulin+sodium Thiosulphate is to help provide extended relief from persistent, disruptive allergy symptoms. Rather than simply masking your symptoms temporarily, it is proposed to lower your immune system's overreactivity to everyday triggers, helping reduce daily interruptions.
- Reduced Dependence on Daily medicines: As observed in clinical practice, some patients may experience a reduced need for daily antihistamines, rescue inhalers, or topical steroids. Any reduction in daily medicine dependence should always be managed under direct medical supervision.
- Improved Quality of Life: Furthermore, by helping to reduce sudden allergy flare-ups, this therapy may support better sleep quality and daily comfort, as observed in post-marketing clinical experience in India.
Directions for Use
- Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
- Histamine+human Normal Immunoglobulin+sodium Thiosulphate will be administered by the doctor or healthcare professional.
- Do not self-administer.
Storage
Side Effects of Histamine+human Normal Immunoglobulin+sodium Thiosulphate
Common Side Effects (Usually mild):
- Redness, mild swelling, or pain at the injection site
- Mild headache
- Low-grade fever or feeling unusually warm
- Mild body aches or temporary tiredness
Serious Side Effects (Consult your doctor right away):
- Signs of a severe allergic reaction (such as swelling of your face, lips, tongue, or throat, severe dizziness, or a widespread rash)
- Sudden difficulty breathing, wheezing, or chest tightness
- Severe headache accompanied by a stiff neck, nausea, or vomiting
- Unusually rapid heart rate or chest pain
Medicines Containing this Salt
View AllDrug Warnings
- Inspect the Solution: Always inspect the liquid vial before use; do not inject the medicine if you see any floating particles, cloudiness, or discolouration.
- Receive Injections in a Healthcare Setting: Ensure your injections are performed in a professional healthcare setting where any rare, immediate allergic reactions can be managed promptly.
- Rotate Injection Sites: Rotate your injection sites with each scheduled dose to prevent skin hardening, irritation, or localised bruising.
- Keep a Treatment Log: Keep a detailed log of your injection dates and any symptoms you experience to help your doctor track your treatment progress.
- Avoid Live Vaccines: Avoid receiving live vaccines (such as the MMR or chickenpox vaccine) close to your treatment schedule, as Histamine+human Normal Immunoglobulin+sodium Thiosulphate may temporarily reduce the vaccine's effectiveness.
Drug Interactions
- Live viral vaccines: May interfere with the immune response to vaccines like measles, mumps, rubella, or varicella. It is generally advised to separate these treatments by several months.
- Systemic corticosteroids or immunosuppressants: May decrease the effectiveness of Histamine+human Normal Immunoglobulin+sodium Thiosulphate by suppressing the natural immune response your body needs to build tolerance.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
safeHistamine+human Normal Immunoglobulin+sodium Thiosulphate may not interact with alcohol. However, limit or avoid the consumption of alcohol to avoid possible side effects.
Pregnancy
unsafeHistamine+human Normal Immunoglobulin+sodium Thiosulphate is not recommended for use in pregnant women. Hence, inform your doctor if you are pregnant or planning to become pregnant before receiving Histamine+human Normal Immunoglobulin+sodium Thiosulphate. Your doctor may suggest an alternative medicine based on your health condition.
Breast Feeding
cautionInform your doctor if you are breastfeeding before receiving Histamine+human Normal Immunoglobulin+sodium Thiosulphate. Your doctor will assess the benefits and the risks before prescribing.
Driving
safeHistamine+human Normal Immunoglobulin+sodium Thiosulphate usually does not affect your ability to drive or operate machinery.
Liver
cautionLet your doctor know if you have any history of liver diseases. Your doctor will weigh the benefits and potential risks before prescribing Histamine+human Normal Immunoglobulin+sodium Thiosulphate.
Kidney
cautionLet your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Histamine+human Normal Immunoglobulin+sodium Thiosulphate.
Children
safe if prescribedHistamine+human Normal Immunoglobulin+sodium Thiosulphate can be safely used in children when prescribed by a paediatrician.
Habit Forming
Diet & Lifestyle Advise
- Avoid Allergy Triggers: Identify and minimise exposure to your specific allergy triggers, such as dust mites, pet dander, mould, or certain foods.
- Use a HEPA Purifier: Use a high-efficiency particulate air (HEPA) purifier in your bedroom to reduce airborne allergens while you sleep.
- Stay Well-Hydrated: Stay well-hydrated by drinking plenty of water, which helps keep your respiratory pathways moist and thins out mucus.
- Eat a Balanced Diet: Eat a balanced diet rich in antioxidant-filled foods like fresh berries, leafy greens, and nuts to support your immune system's health.
- Avoid Smoking: Avoid smoking and limit your exposure to secondhand smoke, which can severely irritate your airways and worsen asthma symptoms.
Special Advise
It is advised to avoid contact with known allergens (allergy-causing agents) such as pollen, dust, etc. Certain food items are known to cause allergies to you.
Histamine+human Normal Immunoglobulin+sodium Thiosulphate should not be given intravenously.
Do not take any vaccines (especially live vaccines) at least three months after taking Histamine+human Normal Immunoglobulin+sodium Thiosulphate as this medicine may make the vaccine less effective.
Patients Concern
Disease/Condition Glossary
Allergic rhinitis: When the immune system overreacts to allergens in the air, allergic rhinitis, a type of nasal inflammation, results. Runny or stuffy nose, sneezing, red, itchy, and watery eyes, as well as swelling around the eyes, are signs and symptoms of this condition. Dust mites, pollen, spores, animal skin, urine, and saliva are among the most common airborne allergens that cause rhinitis.
Urticaria: Hives, or urticaria, are sudden outbreaks of swollen, pale red bumps or plaques (wheals) on the skin that can occur as a result of an immune system reaction to certain allergens or for unknown causes. The skin's surface may develop welts that are itchy, raised, red, or skin-coloured.
Premenstrual syndrome (PMS): It is a condition in which a group of symptoms occurs between ovulation and menstruation. Symptoms of PMS include mood swings, fatigue, food cravings, breast tenderness, and irritability.
Eczema is a condition in which skin patches become inflamed, itchy, cracked, and rough. Symptoms include a rash on the arms and behind the knees. Eczema can be triggered by various factors, such as foods, drinks, skin products, soaps, chemicals, detergents, make-up products, chlorinated pools, and stress.
FAQs
Histamine+human Normal Immunoglobulin+sodium Thiosulphate is used to treat Allergic rhinitis, Urticaria, Eczema and Premenstrual syndrome (PMS).
Histamine+human Normal Immunoglobulin+sodium Thiosulphate contains a combination of three medicines, Human Normal Immunoglobulin, Histamine and Sodium Thiosulphate, which are used in the treatment of allergic reactions like allergic rhinitis and urticaria. This medicine works by blocking the action of certain chemical messengers that are responsible for inflammation, congestion, itching and other allergic reactions. It is also used in the treatment of eczema, premenstrual syndrome, bronchitis, and migraine.
Histamine+human Normal Immunoglobulin+sodium Thiosulphate may alter some blood test results for a certain time, so inform your doctor that you have received Histamine+human Normal Immunoglobulin+sodium Thiosulphate before undergoing blood tests. Taking any vaccines (especially live vaccines) at least three months after the administration of Histamine+human Normal Immunoglobulin+sodium Thiosulphate is not recommended as this medicine may make the vaccines less effective.
Histamine+human Normal Immunoglobulin+sodium Thiosulphate will be administered by the doctor or nurse through a subcutaneous route (injection given in the fatty tissue, just under the skin). Do not self-administer.
Inform the doctor about your complete medical history, including any medications, herbal supplements, and vitamins you are taking or if you have recently received any vaccinations. Let the doctor know if you are breastfeeding, as they will assess the risks and benefits before administering Histamine+human Normal Immunoglobulin+sodium Thiosulphate. This medication is not recommended for use during pregnancy, so inform your doctor if you are pregnant or planning to become pregnant. Your doctor may suggest an alternative treatment based on your health condition.
Allergic rhinitis is an allergic reaction that affects the nasal passages, leading to symptoms such as sneezing, a runny nose, and congestion. Chronic urticaria, or hives, involves the recurring appearance of raised, itchy welts on the skin due to an allergic response or other triggers. The main difference is that allergic rhinitis affects the nose, whereas chronic urticaria affects the skin.
Histamine+human Normal Immunoglobulin+sodium Thiosulphate should not be administered if you are allergic to any of its ingredients. Do not receive any vaccines, especially live vaccines, for at least three months after taking Histamine+human Normal Immunoglobulin+sodium Thiosulphate, as this medication may reduce the effectiveness of the vaccine.
It is unlikely that Histamine+human Normal Immunoglobulin+sodium Thiosulphate interacts with alcohol. However, it is recommended to limit or avoid alcohol consumption to reduce the risk of potential side effects.
The side effects of Histamine+human Normal Immunoglobulin+sodium Thiosulphate include headache, swelling or hardening at the injection site, and flu-like symptoms (such as runny nose and sore throat). These side effects are typically mild and temporary. However, if any of these side effects persist or worsen, consult the doctor.
There is limited clinical information regarding the safety of Histamine+human Normal Immunoglobulin+sodium Thiosulphate during pregnancy. It should only be used if your doctor determines that the benefits clearly outweigh the risks. Talk to your doctor if you are pregnant or planning to become pregnant.
Immunoglobulins can temporarily interfere with your body's ability to develop an effective immune response to live viral vaccines (such as MMR or chickenpox). Because standard multi-month deferral rules apply primarily to high-dose intravenous immunoglobulin (IVIG) therapy, the precise timing and deferral window for this low-dose combination formulation must be determined directly by your treating physician based on your personal injection schedule.
Histamine+human Normal Immunoglobulin+sodium Thiosulphate is designed to significantly reduce your body's sensitivity to allergens and provide long-term symptom control, but it is not classified as a permanent cure. Talk to your doctor to understand your long-term treatment plan.
Mild redness, swelling, or soreness is common and usually goes away on its own within a few days. Applying a cool compress gently to the area can help. If the swelling worsens, becomes hot, or is highly painful, talk to your doctor immediately.
Yes, Histamine+human Normal Immunoglobulin+sodium Thiosulphate does not typically cause drowsiness or affect your ability to drive. However, if you feel dizzy or unwell immediately after your injection, wait until you feel fully alert before driving. Talk to your doctor if you have concerns.
The total number of injections and cycles varies depending on your specific allergic condition and how well you respond to the treatment. Your healthcare provider will establish a personalised schedule for you. Talk to your doctor about your dosing plan.
This medicine can be prescribed to children for specific allergic conditions, but it must be carefully evaluated and monitored by a paediatrician. Talk to your doctor to find out if this treatment is appropriate for your child.
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