Mirabegron
About Mirabegron
Mirabegron is a prescription tablet used primarily in adults to treat an overactive bladder. It helps manage symptoms such as a sudden, urgent need to urinate, frequent urination, and accidental urine leaks. Living with an overactive bladder can sometimes feel frustrating or embarrassing, but effective treatment can help improve your confidence and quality of life. In some situations, your doctor may prescribe Mirabegron together with another bladder medicine, such as an antimuscarinic medicine, to improve symptom control. If you are already taking medicines for bladder problems, let your doctor know before starting treatment.
Take Mirabegron once daily, at the same time each day, to keep a consistent level in your body. You can take the tablet with or without food, but you should swallow it whole with a glass of water. Making simple daily changes, such as cutting down on caffeine and alcohol, can also help improve your bladder control.
While using Mirabegron, you may experience mild side effects like a dry mouth, headache, or a slightly fast heart rate. However, if you notice severe symptoms like a sudden spike in blood pressure, pain when urinating, or difficulty passing urine, you must contact your doctor immediately.
Talk to your doctor before starting Mirabegron if you have severe kidney or liver damage, or if you have very high, uncontrolled blood pressure. Mirabegron is not recommended for individuals who have a complete blockage of the bladder or are unable to empty their bladder on their own.
Mirabegron can interact with certain blood pressure medicines, heart medicines, and other bladder medicines, which may increase the risk of side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist before starting treatment. Because there is limited information about its safety during pregnancy, Mirabegron is generally not recommended unless your doctor decides it is necessary.
Uses of Mirabegron
Medicinal Benefits
Mirabegron helps improve bladder control and reduce symptoms of an overactive bladder, allowing you to carry out daily activities with greater confidence and comfort. By relaxing the bladder muscles, it supports better urinary control and improves overall quality of life.
Benefits may include:
- Helps reduce frequent and urgent urges to urinate.
- Helps decrease episodes of urinary leakage and incontinence.
- Increases bladder capacity, allowing you to hold urine for longer.
- Helps reduce nighttime urination, promoting better sleep quality.
- Improves confidence and comfort during work, travel, and social activities.
- Supports better bladder control and overall quality of life.
Directions for Use
- Mirabegron can be taken with or without food.
- It is usually taken once daily or as prescribed by your doctor.
- Swallow Mirabegron as a whole with a glass of water.
- Do not crush, chew, or break it.
Storage
Side Effects of Mirabegron
Common Side Effects (Usually mild):
- Dry mouth
- Headache
- Common cold symptoms (such as a runny or stuffy nose)
- Mild increase in heart rate
Serious Side Effects (Call a doctor right away):
- Severe, sudden increase in blood pressure (which may cause a severe headache, blurry vision, or buzzing in your ears)
- Inability to empty your bladder (urinary retention)
- Pain or difficulty when urinating
- Signs of an allergic reaction, such as swelling of the face, lips, tongue, or throat, hives, or trouble breathing
Medicines Containing this Salt
View AllDrug Warnings
- Monitor your blood pressure regularly: Mirabegron may increase blood pressure. Check your blood pressure as advised by your doctor and contact your healthcare provider if your readings remain above your target range.
- Do not start treatment if your blood pressure is uncontrolled: Mirabegron should not be started if you have severely uncontrolled high blood pressure unless specifically advised by your doctor.
- Report difficulty passing urine: Tell your doctor immediately if you have trouble emptying your bladder, a weak urine stream, or symptoms of urinary retention.
- Inform your doctor about all medicines: Tell your healthcare provider about all prescription medicines, over-the-counter products, and supplements you are taking, especially medicines for depression, heart rhythm disorders, or bladder problems, as interactions may occur.
- Discuss kidney or liver problems with your doctor: Inform your healthcare provider if you have severe kidney or liver impairment, as your dose may need to be adjusted and additional monitoring may be required.
Drug Interactions
- Certain heart medicines (e.g., metoprolol, digoxin): Mirabegron may increase the levels of these medicines in the body, raising the risk of side effects. Your doctor may monitor you more closely or adjust the dose.
- Certain psychiatric medicines (e.g., desipramine, thioridazine): Taking these alongside Mirabegron may increase their levels in the body and raise the risk of side effects.
- Other medicines for overactive bladder: Using these together with Mirabegron may increase the risk of side effects and may require dose adjustments or closer monitoring.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid taking alcohol as it increases the risk of side effects.
Pregnancy
consult your doctorMirabegron is not recommended for use in pregnant women unless absolutely necessary. Before taking this medicine, the risks and benefits should be discussed with the doctor.
Breast Feeding
consult your doctorMirabegron is not recommended for use in breastfeeding women unless absolutely necessary. Before taking this medicine, the risks and benefits should be discussed with the doctor.
Driving
cautionThe use of this medicine may cause blurred vision or dizziness in some patients. You are advised not to perform any activities, such as driving a vehicle or operating machinery, if you experience any of these symptoms during treatment with this medicine.
Liver
cautionMirabegron should be used with caution in patients with severe liver disease. A dose adjustment of Mirabegron may be needed. Please consult your doctor. Mirabegron is not recommended for use in patients with severe liver disease.
Kidney
cautionMirabegron should be used with caution in patients with kidney disease. A dose adjustment of Mirabegron may be needed. Please consult your doctor.
Children
unsafeMirabegron should not be used in children below 12 years of age unless prescribed by a doctor.
Habit Forming
Diet & Lifestyle Advise
- Avoid bladder irritants: Limit caffeine, alcohol, artificial sweeteners, and spicy foods, as they can irritate the bladder and worsen sudden urges to urinate.
- Practice pelvic floor exercises: Perform Kegel exercises regularly to help strengthen the muscles that support your bladder and improve bladder control.
- Maintain a healthy weight: Aim for a healthy body weight, as excess abdominal weight can place additional pressure on the bladder.
- Limit fluids before bedtime: Avoid drinking large amounts of fluids close to bedtime to help reduce nighttime urination.
- Stay well hydrated: Drink moderate amounts of water throughout the day, as drinking too little can irritate the bladder and make urinary symptoms worse.
Special Advise
- Mirabegron may raise your blood pressure. Monitor your blood pressure regularly.
Patients Concern
Disease/Condition Glossary
Overactive bladder (OAB): In normal conditions, when the urinary bladder is filled with urine, it sends a message to the brain that an individual is ready to urinate. During the urination process, bladder muscles contract, which ultimately leads to a uniform flow of urine. Contrary to this, in an overactive bladder (OAB), the urinary bladder muscles start contracting before the urine is filled in the urinary bladder, thereby causing frequent urges to urinate.
FAQs
Mirabegron belongs to the group of medications called urinary antagonists or antispasmodics primarily used in the treatment of overactive bladder (OAB) symptoms.
Mirabegron prevents sudden bladder muscle contractions and increases the volume and amount of urine the bladder can hold. Thus, Mirabegron helps to control the release of urine and helps reduce symptoms of OAB like a strong urge to urinate, frequent urination and reduced urine flow.
If you have kidney disease, liver disease, hypertension, urinary retention, angioedema, history of heart rhythm problems (including QT prolongation), please contact a doctor before taking Mirabegron.
Ketoconazole is an antifungal medicine, and it may interact with Mirabegron. So, inform your doctor about all the prescription and non-prescription medicines before taking Mirabegron to avoid unwanted effects.
Mirabegron may cause side effects such as nausea, headache, diarrhea, constipation, increased heart rate and dizziness. If these side effects persist or worsen, please consult your doctor.
No, Mirabegron is not recommended for children as the safety and effectiveness were not established.
No, Mirabegron is not known to cause an addiction. However, it should be taken in the dose and for duration as prescribed by your doctor.
Mirabegron should be taken for as long as it is advised by the doctor. Follow all the instructions and do not discontinue taking Mirabegron on your own.
No, Mirabegron does not affect sleep. However, if you have any sleep related problems, consult your doctor.
No, you are recommended to take Mirabegron daily as advised by your doctor as it controls your condition and does not cure it. Since your bladder takes time to adapt to the medicine, if you take it off and on, you will not get the desired benefits and your symptoms will recur.
Mirabegron may cause side effects such as infection of kidneys, urinary bladder, ureters, or urethra but does not affect everyone. Mirabegron has been associated with very few reports of developing bladder pain and kidney stones. Also, patients with compromised kidney function should be careful while using Mirabegron and in case of any unwanted symptoms related to kidneys, inform your doctor.
If you accidentally take more than the required dose of Mirabegron, seek medical help immediately even if you do not feel any discomfort. Overdose of Mirabegron may increase your blood pressure and pulse rate resulting in severe headache, chest pain, palpitations and fatigue.
Yes, you can take this tablet with or without food. However, you should try to take it the same way each day to ensure a consistent effect. Talk to your doctor.
Dry mouth is a possible side effect of Mirabegron, though it happens less frequently compared to some older bladder medications. If dry mouth becomes bothersome or severe, talk to your doctor.
No, you must swallow the tablet whole with a glass of water. Crushing, chewing, or breaking the tablet can interfere with how the medicine is slowly released into your body.
Yes, this medication can increase blood pressure, especially if you already have a history of high blood pressure. You should have your blood pressure checked regularly while taking Mirabegron.
If you remember on the same day, take the missed tablet as soon as possible. If more than 12 hours have passed since your scheduled dose, skip it and take your next dose at the usual time.
While there is no direct chemical interaction, alcohol can irritate your bladder and worsen symptoms of urgency and frequency. It is best to limit alcohol intake while treating an overactive bladder.
You should not stop taking Mirabegron without consulting your healthcare provider, even if you feel better. Stopping early may cause your overactive bladder symptoms to return. Consult your doctor.
Author Details
