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Aspirin uses vary according to its strength. In low doses (about 75 mg), Aspirin is used to prevent heart attack and stroke. On the other hand, a high dose (about 325 mg) helps relieve pain. Low-dose aspirin makes the blood less sticky, reducing the risk of heart attack and stroke. High-dose aspirin inhibits the activity of prostaglandins, which causes pain and inflammation. In some cases, you may experience side effects such as stomach upset, heartburn, drowsiness, mild headache, ankle swelling (oedema), slow heart rate, and nausea.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Aspirin 50mg Tablet DR
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

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Drug-Drug Interactions

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Drug-Drug Interaction: Inform your doctor if you are taking blood thinners (warfarin, heparin, phenindione, clopidogrel), immune related drugs (cyclosporin, tacrolimus), high blood pressure pills (captopril, metoprolol), heart disease related pills (acetazolamide, digoxin), antidepressant (fluoxetine, sertraline, lithium), pain killers (ketorolac, naproxen, ibuprofen), steroids, gout drug (probenecid), anti-epilepsy drug (valproate, phenytoin), anti-cancer or anti-arthritis drug (methoxtrexate), anti-diabetic pills (glibenclamide), abortion pill (mifepristone), acetazolamide, and osteoporosis related drug (alendronate).

Drug-Food Interaction: Taking Aspirin 50mg Tablet DR along with alcohol, caffeine and herbal supplements like ‘ginkgo biloba’ can affect the working and potentiate the side effects of this medicine.

Drug-Disease Interaction: Inform your doctor if you have a blood clotting disorder (haemophilia), bleeding disorder, von Willebrand's disease, or telangiectasia, asthma, liver/kidney problem, stomach or intestinal ulcer, or severe heart problems.

Drug-Drug Interactions

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How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Co-administration of Ketorolac and Aspirin 50mg Tablet DR may increase the risk of side effects.

How to manage the interaction:
Taking Ketorolac with Aspirin 50mg Tablet DR is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting fresh or dried blood, severe headache and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Combining Ketorolac tromethamine with Aspirin 50mg Tablet DR can increase the risk of adverse effects.

How to manage the interaction:
Taking Aspirin 50mg Tablet DR with Ketorolac tromethamine is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice.
AspirinEdoxaban
Severe
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
When edoxaban is used with Aspirin 50mg Tablet DR, the risk of bleeding may increase.

How to manage the interaction:
Although there is a possible interaction between Aspirin 50mg Tablet DR and edoxaban, you can take these medicines together if prescribed by a doctor. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without consulting a doctor.
AspirinMethazolamide
Severe
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Taking Aspirin 50mg Tablet DR with methazolamide may cause side effects.

How to manage the interaction:
Although there is a possible interaction between Aspirin 50mg Tablet DR and methazolamide, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as ringing in your ears, headache, nausea, vomiting, dizziness, confusion, hallucinations, or rapid breathing, fever, seizure (convulsions), please contact a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Using Aspirin 50mg Tablet DR together with tirofiban can cause you to bleed more easily.

How to manage the interaction:
Co-administration of Aspirin 50mg Tablet DR with Tirofiban can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: bleeding, bruising, throwing up, headache, feeling dizzy, weakness, or seeing blood in your urine or stools. Do not stop using any medications without talking to a doctor.
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
The use of panobinostat with Aspirin 50mg Tablet DR may increase the risk of bleeding.

How to manage the interaction:
Taking panobinostat with Aspirin 50mg Tablet DR together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AspirinDefibrotide
Severe
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Coadministration of Aspirin 50mg Tablet DR with Defibrotide may increase the risk of bleeding.

How to manage the interaction:
Taking Aspirin 50mg Tablet DR with Defibrotide together can result in an interaction, but it can be taken if a doctor has advised it. It is important to closely monitor your body for any signs of bleeding issues. If you notice any symptoms like bleeding, bruising, dizziness, severe headache, weakness, or vomiting, it is recommended to contact a doctor right away. Regular check-ups and tests will help ensure your safety and well-being. Do not discontinue any medications without consulting a doctor.
AspirinPonatinib
Severe
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Using Ponatinib together with Aspirin 50mg Tablet DR may increase the risk of bleeding.

How to manage the interaction:
Taking Ponatinib with Aspirin 50mg Tablet DR together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Coadministration of warfarin with Aspirin 50mg Tablet DR may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Aspirin 50mg Tablet DR and warfarin, you can take these medicines together if prescribed by a doctor. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Aspirin 50mg Tablet DR 50mg Tablet DR:
Co-administration of Aspirin 50mg Tablet DR and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Although Co-administration of Aspirin 50mg Tablet DR and Rivaroxaban can lead to an interaction, they can be taken together if advised by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ASPIRIN-50MGCaffeine containing foods/drinks
Mild

Drug-Food Interactions

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ASPIRIN-50MGCaffeine containing foods/drinks
Mild
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine containing products during Aspirin 50mg Tablet DR therapy may result in increased Aspirin 50mg Tablet DR levels leading to side effects. It is advised to avoid the consumption of caffeine containing products during treatment with Aspirin 50mg Tablet DR.

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