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Aximac 5 mg Tablet is used to treat Renal Cell Carcinoma. It contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor. In this way, Aximac 5 mg Tablet stops the production, spread and growth of cancerous cells.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Aximac 5 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

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Drug-Drug Interactions

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Drug-Drug Interactions: Aximac 5 mg Tablet may have interaction with strong CYP3A4/5 inhibitors (clarithromycin, diltiazem, erythromycin, itraconazole, ketoconazole, ritonavir), strong CYP3A4/5 inducers (carbamazepine, rifampicin, phenytoin, phenobarbitone, dexamethasone).

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI perforation, lung toxicity, thyroid dysfunction, or thromboembolism before starting the treatment.

Drug-Drug Interactions

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How does the drug interact with Aximac 5 mg Tablet:
Taking Aximac 5 mg Tablet with ritonavir may significantly increase the blood levels of Aximac 5 mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Aximac 5 mg Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aximac 5 mg Tablet:
Taking thalidomide together with Aximac 5 mg Tablet may increase the risk of blood clots and others complications.

How to manage the interaction:
Although taking Aximac 5 mg Tablet and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aximac 5 mg Tablet:
Coadministration of Aximac 5 mg Tablet with primidone may decrease the blood levels of Aximac 5 mg Tablet, which may make Aximac 5 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between primidone and Aximac 5 mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aximac 5 mg Tablet:
Coadministration of Rifabutin may decrease the blood levels of Aximac 5 mg Tablet.

How to manage the interaction:
Although taking Aximac 5 mg Tablet and Rifabutin together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Aximac 5 mg Tablet:
Taking Aximac 5 mg Tablet with bosentan may significantly reduce the blood levels of Aximac 5 mg Tablet, making the medication less effective in treating the condition.

How to manage the interaction:
Although using Bosentan and Aximac 5 mg Tablet together can result in an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
AxitinibConivaptan
Severe
How does the drug interact with Aximac 5 mg Tablet:
When Aximac 5 mg Tablet is taken with Conivaptan, the breakdown of Aximac 5 mg Tablet in the body may be reduced.

How to manage the interaction:
Co-administration of Aximac 5 mg Tablet with Conivaptan can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AxitinibNefazodone
Severe
How does the drug interact with Aximac 5 mg Tablet:
Co-administration of Aximac 5 mg Tablet with nefazodone may cause Aximac 5 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Taking Aximac 5 mg Tablet with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
How does the drug interact with Aximac 5 mg Tablet:
Coadministration of Modafinil with Aximac 5 mg Tablet may decrease the blood levels of Aximac 5 mg Tablet, which may make Aximac 5 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Aximac 5 mg Tablet and Modafinil, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibTelithromycin
Severe
How does the drug interact with Aximac 5 mg Tablet:
Co-administration of Aximac 5 mg Tablet with telithromycin may cause Aximac 5 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Taking Aximac 5 mg Tablet with Telithromycin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibFosphenytoin
Severe
How does the drug interact with Aximac 5 mg Tablet:
Fosphenytoin may decrease the blood levels of Aximac 5 mg Tablet, which may make Aximac 5 mg Tablet less effective in treating your condition

How to manage the interaction:
Co-administration of Aximac 5 mg Tablet with Fosphenytoin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Aximac 5 mg Tablet.

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