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Hepaglan-25 Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. It contains Heparin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. Some people may experience haemorrhage (bleeding), thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Drug-Drug Interactions

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HeparinOritavancin
Critical

Drug-Drug Interactions

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How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Tenecteplase with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Tenecteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
HeparinOritavancin
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Using Hepaglan-25 Injection 5 ml with Oritavancin can make Hepaglan-25 Injection 5 ml less effective as a therapy.

How to manage the interaction:
Hepaglan-25 Injection 5 ml is not recommended within 120 hours (5 days) of taking oritavancin. Oritavancin can interfere with certain of the major coagulation tests used to assess Hepaglan-25 Injection 5 ml's effectiveness and safety, it can be taken only if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Ticlopidine with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Ticlopidine with Hepaglan-25 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Mifepristone with Hepaglan-25 Injection 5 ml can increase the risk of negative side effects.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Mifepristone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinBazedoxifene
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
When Hepaglan-25 Injection 5 ml is taken with bazedoxifene the effects of Hepaglan-25 Injection 5 ml are reduced by bazedoxifene.

How to manage the interaction:
Taking Bazedoxifene with Hepaglan-25 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Alteplase with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Alteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking fondaparinux with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Fondaparinux with Hepaglan-25 Injection 5 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
HeparinProtamine
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
When Protamine and Hepaglan-25 Injection 5 ml are used together, can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Protamine and Hepaglan-25 Injection 5 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
HeparinAntithrombin iii
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
Using Hepaglan-25 Injection 5 ml together with antithrombin III may increase the risk of bleeding.

How to manage the interaction:
Although taking Antithrombin iii and Hepaglan-25 Injection 5 ml together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs - bleeding, bruising, vomiting, headache, dizziness, weakness, or blood in your urine or stools, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Hepaglan-25 Injection 5 ml:
Co-administration of Hepaglan-25 Injection 5 ml and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Hepaglan-25 Injection 5 ml and Rivaroxaban can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HEPARIN-25000IUHerbal products/medicines
Moderate

Drug-Food Interactions

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HEPARIN-25000IUHerbal products/medicines
Moderate
Common Foods to Avoid:
Garlic Pill

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml along with herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba can lead to an increased risk of bleeding Avoid taking herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba while taking Hepaglan-25 Injection 5 ml.

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