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Hepraject 25000 IU Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. It contains Heparin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. Some people may experience haemorrhage (bleeding), thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Drug-Drug Interactions

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HeparinBazedoxifene
Critical

Drug-Drug Interactions

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HeparinBazedoxifene
Critical
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
When Hepraject 25000 IU Injection 5 ml is taken with bazedoxifene the effects of Hepraject 25000 IU Injection 5 ml are reduced by bazedoxifene.

How to manage the interaction:
Taking Bazedoxifene with Hepraject 25000 IU Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Taking Alteplase with Hepraject 25000 IU Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepraject 25000 IU Injection 5 ml with Alteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Taking Tenecteplase with Hepraject 25000 IU Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepraject 25000 IU Injection 5 ml with Tenecteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Taking Ticlopidine with Hepraject 25000 IU Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Ticlopidine with Hepraject 25000 IU Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinOritavancin
Critical
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Using Hepraject 25000 IU Injection 5 ml with Oritavancin can make Hepraject 25000 IU Injection 5 ml less effective as a therapy.

How to manage the interaction:
Hepraject 25000 IU Injection 5 ml is not recommended within 120 hours (5 days) of taking oritavancin. Oritavancin can interfere with certain of the major coagulation tests used to assess Hepraject 25000 IU Injection 5 ml's effectiveness and safety, it can be taken only if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Taking Mifepristone with Hepraject 25000 IU Injection 5 ml can increase the risk of negative side effects.

How to manage the interaction:
Taking Hepraject 25000 IU Injection 5 ml with Mifepristone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Co-administration of Cangrelor with Hepraject 25000 IU Injection 5 ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Although there is a possible interaction between Hepraject 25000 IU Injection 5 ml and Cangrelor, you can take these medicines together if prescribed by a doctor. However, if you have any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, you should seek immediate medical attention. Do not stop using any medications without a doctor's advice.
HeparinPiperacillin
Severe
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
When used together Piperacillin will raise the amount of anticoagulant(blood thinners, are chemical substances that prevent or reduce clotting of blood) effect of Hepraject 25000 IU Injection 5 ml.

How to manage the interaction:
Although there is a possible interaction between Piperacillin and Hepraject 25000 IU Injection 5 ml, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
When Cefazolin is used with Hepraject 25000 IU Injection 5 ml, it enhances the effects of Hepraject 25000 IU Injection 5 ml.

How to manage the interaction:
Although taking Hepraject 25000 IU Injection 5 ml and Cefazolin together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor if you experience bleeding, bruising, throwing up, headache, feeling lightheaded, feeling weak, or blood in your urine or stools. Do not stop using any medications without talking to a doctor.
How does the drug interact with Hepraject 25000 IU Injection 5 ml:
Taking Tirofiban with Hepraject 25000 IU Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Hepraject 25000 IU Injection 5 ml and Tirofiban, you can take these medicines together if prescribed by a doctor. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HEPARIN-5000IUHerbal products/medicines
Moderate

Drug-Food Interactions

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HEPARIN-5000IUHerbal products/medicines
Moderate
Common Foods to Avoid:
Garlic Pill

How to manage the interaction:
Taking Hepraject 25000 IU Injection 5 ml along with herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba can lead to an increased risk of bleeding Avoid taking herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba while taking Hepraject 25000 IU Injection 5 ml.

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