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Supral Plus Tablet is used to treat schizophrenia and bipolar disorder (manic depression). It contains Fluoxetine and Olanzapine which work by restoring the balance of certain natural substances in the brain. In some cases, this medicine may cause side effects such as drowsiness, lightheadedness, restlessness, irritability, tremors, dry mouth, constipation, and increased appetite. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Supral Plus Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

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Drug-Drug Interactions

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Drug-Drug Interactions: Supral Plus Tablet may interact with other benzodiazepines or anti-anxiety drugs (lorazepam and diazepam) and opioid analgesics (tramadol and codeine).

Drug-Food Interactions: Supral Plus Tablet may interact with alcohol, increasing drowsiness.

Drug-Disease Interactions: Supral Plus Tablet should be used with caution in patients with dementia, CNS (central nervous system) depression, obesity, eye problems, acute alcohol intoxication (change in mental behaviour after alcohol consumption), brain stroke, heart diseases, hyperlipidemia (lipid alterations), hyperglycemia/diabetes, liver disease, kidney problems, epilepsy, and parkinsonism (brain disorder).

Olanzapine + FluoxetinePotassium citrate
Critical

Drug-Drug Interactions

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Olanzapine + FluoxetinePotassium citrate
Critical
How does the drug interact with Supral Plus Tablet:
Taking Supral Plus Tablet with Potassium citrate can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Supral Plus Tablet and Potassium citrate leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Co-administration of metoclopramide with Supral Plus Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Supral Plus Tablet and metoclopramide, you can take these medicines if prescribed by a doctor. However, if you experience any symptoms like muscle movements which are not controllable, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, jitteriness, restlessness, or foot tapping, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Taking Supral Plus Tablet with Potassium chloride (oral form) can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Supral Plus Tablet and Potassium chloride leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Supral Plus Tablet:
The use of Supral Plus Tablet and Metrizamide together may raise the risk of seizures (fits).

How to manage the interaction:
Although using Supral Plus Tablet and Metrizamide together causes an interaction, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like loss of consciousness, anxiety, starring, weakness or uncontrolled muscle jerking, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Combining Supral Plus Tablet with Zonisamide can increase the risk of side effects.

How to manage the interaction:
Taking Supral Plus Tablet with Zonisamide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any symptoms like decreased sweating, fever, drowsiness, dizziness, lightheadedness, nausea, vomiting, tiredness, headache, confusion, irritability, or muscle pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Using Supral Plus Tablet together with Venlafaxine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Venlafaxine and Supral Plus Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, dizziness, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Using Supral Plus Tablet together with Paroxetine can increase the blood levels of both the medications.

How to manage the interaction:
Although using Paroxetine and Supral Plus Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, dizziness, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
The combined use of Fluvoxamine and Supral Plus Tablet can increase the blood levels of Supral Plus Tablet.

How to manage the interaction:
Although co-administration of Fluvoxamine and Supral Plus Tablet can lead to an interaction, but it can be taken if a doctor advises it. However, if you experience dizziness, drowsiness, dry mouth, difficulty in passing stools, increased hunger, priapism (prolonged and painful erection unrelated to sexual activity), rapid or slow heartbeat, fits, confusion, hallucination, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Supral Plus Tablet:
Combining Supral Plus Tablet with Chloroquine can increase the risk of irregular heart beat.

How to manage the interaction:
Taking Supral Plus Tablet with Chloroquine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of the symptoms like loose stools, vomiting, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heart beat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Supral Plus Tablet:
Using Supral Plus Tablet together with Tramadol can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Tramadol and Supral Plus Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, dizziness, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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