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Sysron-N Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Sysron-N Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Sysron-N Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Sysron-N Tablet as it may increase the levels of Sysron-N Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Sysron-N Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Sysron-N Tablet .

NorethisteroneTelaprevir
Severe

Drug-Drug Interactions

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NorethisteroneTelaprevir
Severe
How does the drug interact with Sysron-N Tablet:
Using Telaprevir and Sysron-N Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Sysron-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Co-administration of Sysron-N Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Sysron-N Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Sysron-N Tablet:
Coadministration of Acitretin with Sysron-N Tablet may interfere with the contraceptive effect of Sysron-N Tablet.

How to manage the interaction:
Acitretin and Sysron-N Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
NorethisteroneBexarotene
Severe
How does the drug interact with Sysron-N Tablet:
Coadministration of Bexarotene and Sysron-N Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Sysron-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Coadministration of Phenytoin and Sysron-N Tablet may decrease the blood levels of Sysron-N Tablet, which may make Sysron-N Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Sysron-N Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Sysron-N Tablet:
Using Felbamate and Sysron-N Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Sysron-N Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Taking Sysron-N Tablet with rifampicin can decrease the blood levels of Sysron-N Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Sysron-N Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneRifapentine
Severe
How does the drug interact with Sysron-N Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Sysron-N Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Eslicarbazepine may reduce the effects of Sysron-N Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Sysron-N Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Sysron-N Tablet:
Coadministration of Sysron-N Tablet with Fosphenytoin can reduces the blood levels and effects of Sysron-N Tablet .

How to manage the interaction:
Taking Sysron-N Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Sysron-N Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Sysron-N Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Sysron-N Tablet dose.

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