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Drug-Drug Interactions: Brufen MR Capsule may interact with other NSAIDs, blood thinners (warfarin, heparin, clopidogrel, and ticlopidine), medicines used to treat abnormal heart rhythms (amiodarone, mexiletine, and propafenone), a medicine used to treat stomach ulcer (cimetidine), antibiotics (enoxacin, pefloxacin, and norfloxacin), painkiller (rofecoxib), oral contraceptives, medicines used to treat high blood pressure including water pills, beta-blockers (atenolol and propranolol), a medicine used to treat heart disease (digoxin), sleeping pill (temazepam), a medicine used to treat cancer (methotrexate), a medicine used to treat fits (phenytoin), antidepressants (lithium, paroxetine, and sertraline), a medicine used to treat high cholesterol (cholestyramine), anti-HIV drugs (zidovudine and ritonavir), a medicine used to treat gout (probenecid), muscle relaxant (baclofen), and antifungal medicines (voriconazole and fluconazole).
Drug-Food Interactions: Brufen MR Capsule may interact with alcohol and increase the risk of side-effects.
Drug-Disease Interactions: Brufen MR Capsule should not be used in patients with bleeding or ulcers in the stomach or intestine, severe liver, kidney, or heart problems, severe dehydration (due to vomiting or diarrhoea), active bleeding (including in the brain), and conditions that cause the abnormal formation of red blood cells.
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