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Dyfira 240 Capsule is used in the treatment of multiple sclerosis, people with clinically isolated syndrome, and relapsing-remitting forms. This medicine works by stopping the body's defence system from damaging the brain and spinal cord, thereby reducing inflammation and avoiding nerve damage. Common side effects include flushing, redness, itching, rash, nausea, vomiting, diarrhoea, stomach pain, and indigestion

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Dyfira 240 Capsule

Dyfira 240 Capsule is a prescription medication used to manage relapsing forms of multiple sclerosis in adults. Its primary purpose is to decrease the frequency of physical flare-ups and help delay the progression of disability. By targeting inflammatory pathways, this medicine protects the central nervous system from ongoing nerve damage.

You will typically take this medication twice daily, and it is crucial to use it consistently at the same times every day to maintain steady levels in your body. While you can take it with or without food, taking your dose with a meal can help minimise temporary side effects like skin flushing. Incorporating stress-reduction techniques and moderate daily movement can also help you get the best results from your treatment.

While taking Dyfira 240 Capsule , some people may experience mild side effects such as temporary flushing, nausea, or stomach discomfort. However, you should contact your doctor immediately if you experience serious symptoms like persistent fatigue, yellowing of the eyes, or signs of a severe infection. Your healthcare team is there to monitor your progress and ensure the treatment remains safe for you.

Before starting this medication, talk to your doctor if you have pre-existing liver damage, a low white blood cell count, or an active infection. Do not take this if you have had a severe allergic reaction to this medication or any of its ingredients in the past. Your doctor will help determine if this is the safest treatment option for your specific health profile.

This medicine can interact with alcohol, which may worsen stomach irritation, and smoking can affect how your body responds to the treatment. Additionally, certain medications that suppress your immune system can increase your risk of infection when combined with this therapy. If you are pregnant, breastfeeding, or planning to start a family, or if you are an older adult, consult your doctor to carefully weigh the benefits and risks.

Uses of Dyfira 240 Capsule

This is used to manage relapsing forms of multiple sclerosis in adults. The detailed uses are as follows:

  • Relapsing forms of multiple sclerosis (RMS): Dyfira 240 Capsule helps reduce the number of active disease flare-ups and delays the progression of physical disability over time.
  • Clinically isolated syndrome (CIS): Dyfira 240 Capsule is prescribed for individuals who have experienced a first physical episode of neurological symptoms, helping to delay the onset of fully developed multiple sclerosis.

Key Benefits

This medicine brings several key health benefits:

  • Supports long-term neurological health: Provide long-term protection for your nervous system, allowing you to maintain your daily physical function and independence.
  • Reduces relapses: Helps reduce the frequency and severity of relapses, which helps you experience fewer disruptions to your routine and less pain or fatigue associated with sudden flare-ups.
  • Slows disability progression: It helps slow down the accumulation of permanent physical disability, supporting your mobility and coordination.
  • Reduces inflammation: Helps reduce the number of active inflammatory lesions in your brain and spinal cord, preserving overall neurological health.
Side effects of Dyfira 240 Capsule
  • Nourish your body with a balanced diet with protein-rich foods like fish, eggs, and beans. Fruits, vegetables, and nuts provide essential vitamins and minerals. If necessary, consider vitamin B12 and folate supplements.
  • Practice good hygiene to protect yourself from infections. Wash your hands often, stay up-to-date on vaccinations, avoid crowded areas, and take care when handling food, pets, and diapers.
  • Aim for a good night's sleep, targeting 8 hours of sleep. Find calm through stress-reducing practices like yoga, meditation, or deep breathing. Regular physical activity can also help.
  • Stay healthy by drinking plenty of water, eating probiotic-rich foods like yoghurt, and limiting processed foods and sugars. Consult your doctor, if you are having difficulties or concerns.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

Directions for Use

  • Dyfira 240 Capsule can be taken with or without food, but taking it with food may help reduce side effects like flushing or stomach upset.
  • Take Dyfira 240 Capsule twice a day, preferably at the same time each day, such as morning with breakfast and evening with dinner. However, follow the dosage and timing advised by the doctor.
  • Swallow Dyfira 240 Capsule as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Dyfira 240 Capsule Works

Dyfira 240 Capsule works by helping to protect your central nervous system from the harmful immune responses that cause multiple sclerosis. Inside the body, it activates a biological pathway known as the Nrf2 pathway (a natural defence system inside your cells that protects them from damage), which plays a major role in how cells defend themselves against oxidative stress and inflammation. By activating this pathway, the medicine helps protect brain and nerve cells from being damaged by toxic molecules. Additionally, it helps regulate your body's immune response, reducing the movement of inflammatory white blood cells into the brain and spinal cord. This limits the inflammation that attacks and strips away the protective sheath around your nerve fibres (myelin), the protective coating around your nerves.
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Alcohol

Consult your doctor

It is unknown whether it is safe to consume alcohol with Dyfira 240 Capsule . However, it is advisable not to take or limit alcohol as a precautionary measure.

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Pregnancy

Consult your doctor

Do not take Dyfira 240 Capsule if you are pregnant unless prescribed by the doctor.

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Breast Feeding

Consult your doctor

Dyfira 240 Capsule is not recommended during lactation. Consult your doctor if you are breastfeeding.

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Driving

Caution

Dyfira 240 Capsule is unlikely to influence your ability to drive and use machines. However, do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Consult your doctor

Dyfira 240 Capsule to be taken with caution, especially if you have a history of liver diseases/conditions. Please consult your doctor to address any concerns.

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Kidney

Consult your doctor

Dyfira 240 Capsule to be taken with caution, especially if you have a history of kidney diseases/conditions. Please consult your doctor if you have any concerns.

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Children

Unsafe

Dyfira 240 Capsule should not be given to children as safety and effectiveness have not been established.

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Heart

Consult your doctor

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Limited information is available regarding the use of Dyfira 240 Capsule in elderly patients. If you have any concerns about the usage of Dyfira 240 Capsule in geriatrics, please consult your doctor.

What if I have taken an overdose of Dyfira 240 Capsule

If you suspect an overdose or have taken too much of this medicine, seek immediate medical attention, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Manage flushing with meals: Take your dose alongside a meal or snack containing healthy proteins and fats, such as Greek yoghurt, cheese, or peanut butter, to help reduce the intensity of temporary skin flushing.
  • Avoid heat triggers: High temperatures can temporarily worsen multiple sclerosis symptoms. Stay in air-conditioned environments during hot days, avoid very hot baths, and use cooling wraps if needed.
  • Eat an anti-inflammatory diet: Focus on a balanced diet rich in leafy green vegetables, colourful berries, whole grains, and omega-3 fatty acids (found in fish like salmon or flaxseeds) to support overall brain and nerve health.
  • Incorporate low-impact exercise: Gentle physical activities like swimming, walking, or adaptive yoga can help maintain muscle strength, balance, and flexibility without overexerting your body.
health query

Have a query?

How Soon It Starts Working

  • The time required for Dyfira 240 Capsule to start to work: The time required for Dyfira 240 Capsule to show its action is unknown.
  • The time for which the effects of Dyfira 240 Capsule last: The duration of action for Dyfira 240 Capsule is clinically unknown.

What if you forget to take Dyfira 240 Capsule

If you miss a dose, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one.

Storage

•Store Dyfira 240 Capsule at room temperature, ideally between 68°F and 77°F (20°C to 25°C). •Keep the capsules in their original packaging to protect them from light, and do not transfer them to alternative pillboxes unless advised by a pharmacist.

Drug Warnings

  • Complete regular tests: Complete all recommended blood and urine tests before starting treatment and at regular intervals as directed by your doctor to monitor your liver function and white blood cell levels.
  • Ask about aspirin: Discuss taking a non-enteric-coated aspirin (up to 325 mg) with your doctor before taking your dose, as this is sometimes recommended to help prevent skin flushing.
  • Monitor for symptoms:  Monitor yourself closely for any subtle changes in your thinking, memory, balance, or vision, and report these to your healthcare team immediately.
  • Swallow the capsule whole: Ensure you do not chew, crush, or open the capsule, as breaking the protective coating can increase stomach-related side effects.
  • Keep an updated medicine list: Keep an updated medicine list: Keep an up-to-date list of all medications, supplements, and herbal products you take, and share it with your pharmacist or doctor before starting any new treatments.
  • PML monitoring: Your doctor may recommend JC virus (JCV) antibody testing and regular blood tests to help assess your risk of progressive multifocal leukoencephalopathy (PML). Discuss your individual risk with your neurologist.
  • Allergy to fumaric acid esters (a group of medicines that includes Dyfira 240 Capsule ): Do not take this medicine if you are allergic to them, other fumaric acid esters, or any of the ingredients in the product. Consult your doctor if you have had an allergic reaction to these medicines before. 

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Other multiple sclerosis medicines (e.g., natalizumab, fingolimod): Do not use these medicines together with Dyfira 240 Capsule unless advised by your neurologist, as combining disease-modifying therapies may increase the risk of serious infections and other side effects.
  • Other immunosuppressants: Using them together may further weaken your immune system and increase the risk of infections.
Critical
Dimethyl fumarateCertolizumab
Severe

Drug-Drug Interactions

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Critical
How does the drug interact with Dyfira 240 Capsule:
Co-administration of BCG vaccine with Dyfira 240 Capsule can increase the risk of infection.

How to manage the interaction:
Taking Dyfira 240 Capsule with the BCG vaccine can possibly lead to an interaction, please consult a doctor before taking it. Do not stop using any medications without a doctor's advice.
Dimethyl fumarateCertolizumab
Severe
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Certolizumab and Dyfira 240 Capsule may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Dyfira 240 Capsule with Certolizumab can possibly result in an interaction, but it can be taken if a doctor has advised it. These signs may include a swollen spleen or liver, stomach pain, ongoing fever, night sweats, and weight loss. If you experience any of these symptoms, make sure to contact your doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dyfira 240 Capsule:
Taking Dyfira 240 Capsule with Baricitinib may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dyfira 240 Capsule can be taken with Baricitinib if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of infection like muscle aches, shortness of breath, blood in phlegm, fever, chills, diarrhea, sore throat, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Lomitapide and Diemthyl fumarate may increase the risk of infection.

How to manage the interaction:
Although taking Dyfira 240 Capsule and Lomitapide together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, liver damage, or bleeding. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Golimumab together with Dyfira 240 Capsule may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between Dyfira 240 Capsule and Golimumab, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away. These symptoms include a serious infection, sepsis, complications, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee. Do not stop using any medications without talking to a doctor.
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Dyfira 240 Capsule with Natalizumab can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Dyfira 240 Capsule with Natalizumab can possibly result in an interaction, but it can be taken if a doctor has advised it. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, burning during urination, weakness, vision problems, or confusion. If you experience any of these symptoms, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Infliximab with Dyfira 240 Capsule can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Infliximab and Dyfira 240 Capsule, you can take these medicines together if prescribed by your doctor. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, or experiencing pain or burning while urinating it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Mipomersen and Dyfira 240 Capsule may significantly increase the risk of liver problems.

How to manage the interaction:
Although taking Dyfira 240 Capsule and Mipomersen together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dyfira 240 Capsule:
Co-administration of Dyfira 240 Capsule with Fingolimod may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dyfira 240 Capsule can be taken with Fingolimod if prescribed by the doctor. Consult the prescriber if you experience signs and symptoms of infection like muscle aches, shortness of breath, blood in phlegm, fever, chills, diarrhea, sore throat, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dyfira 240 Capsule:
Taking Cladribine with Dyfira 240 Capsule can increase the risk of serious infections.

How to manage the interaction:
Taking Dyfira 240 Capsule with Cladribine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination, contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

Certain foods or drinks may affect the safety or tolerability of Dyfira 240 Capsule . Important interactions include:

  • Alcohol: Avoid drinking high-proof alcohol or consuming alcoholic beverages close to the time of your dose, as alcohol may affect how the delayed-release capsule works, which could increase stomach-related side effects like irritation and severe flushing.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Dyfira 240 Capsule is used to treat people with clinically isolated syndrome, relapsing-remitting forms, and secondary progressive types of multiple sclerosis.
Dyfira 240 Capsule stops the body's defence system from damaging the brain and spinal cord. Thereby delaying the worsening of multiple sclerosis. It also reduces inflammation and avoids nerve damage, thus helping treat the symptoms of multiple sclerosis.
Even if you feel better, keep taking Dyfira 240 Capsule for as long as your doctor has prescribed it. Do not discontinue Dyfira 240 Capsule without first consulting your doctor.
There is currently no cure for multiple sclerosis, but several treatments can help control the condition. Dyfira 240 Capsule helps lower the number of relapses and slows down the progression of physical disabilities due to multiple sclerosis.
No, Dyfira 240 Capsule is a medication prescribed by a doctor to treat specific medical conditions such as multiple sclerosis. Taking it on your own can result in adverse effects.
Dyfira 240 Capsule may increase the risk of infections. It is advisable to obtain a complete blood count (CBC) before initiating treatment and monitor for infection during treatment and two months after discontinuation.
Dyfira 240 Capsule may cause common side effects, including flushing, redness, itching, rash, nausea, vomiting, diarrhoea, stomach pain, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen.
While taking Dyfira 240 Capsule , it is important to monitor parameters like white blood cell count, liver function, kidney function, and signs of infection.
Dyfira 240 Capsule is generally not recommended for use during pregnancy and breastfeeding unless necessary. Before taking this medication, the risks and benefits should be discussed with your doctor.
There is no specific information indicating that Dyfira 240 Capsule directly affects thyroid function. However, while taking this medication, it's important to monitor your overall health and report any unusual symptoms to your healthcare provider.
No, you should never crush, chew, or open the capsules. Doing so can destroy the special coating that protects your stomach and ensures the medicine is released correctly in your body. Talk to your doctor or pharmacist if you have trouble swallowing.
You should consult your healthcare provider before getting any vaccines. Live vaccines should generally be avoided during treatment, as your immune system may be less able to handle them. Talk to your doctor or pharmacist before scheduling any vaccinations.
Mild stomach irritation and diarrhoea are common, especially during the first few weeks of starting the treatment. Taking your doses with food can help ease these symptoms, but if they persist or become severe, talk to your doctor or pharmacist right away.
Your doctor will typically order blood tests before you start the medication and then every 6 to 12 months during treatment. These tests check your liver function and monitor your white blood cell levels to ensure the medicine is safe for you to continue. Talk to your doctor for a specific schedule.

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Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - DYF0005
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