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compositionComposition:LEVOTHYROXINE-88MCG
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Prescription Medicine
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LETHYROX 88MCG TABLET is used to treat hypothyroidism (underactive thyroid). It contains Levothyroxine which works by restoring the levels of thyroid hormone. In some cases, this medicine may cause side effects such as vomiting, headache, diarrhoea, restlessness, weight loss, or excitability. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEVOTHYROXINE-88MCG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About LETHYROX 88MCG TABLET

LETHYROX 88MCG TABLET is a prescription thyroid hormone replacement used to treat hypothyroidism, a condition where the thyroid gland does not produce enough thyroid hormone. It is also used to help suppress thyroid-stimulating hormone levels in patients with certain types of thyroid cancer. By providing the body with the hormone it lacks, this medicine helps restore normal metabolic functions.

To achieve the best results, you must take LETHYROX 88MCG TABLET once daily, consistently at the same time every day, on an empty stomach. It is best taken in the morning with a full glass of water, at least 30 to 60 minutes before eating breakfast or drinking caffeinated beverages. Maintaining a consistent diet and avoiding sudden changes in your fibre, soy, or calcium intake can also help ensure the medication is absorbed properly.

While starting this medication, some people may experience mild side effects like temporary hair loss, mild headaches, or feeling overly warm as their body adjusts. However, you should contact your doctor immediately if you experience severe symptoms, such as an irregular heartbeat, chest pain, or extreme shortness of breath.

Before taking this medicine, you must tell your doctor if you have a history of heart disease, diabetes, or problems with your adrenal or pituitary glands. Do not take this if you have an untreated overactive thyroid gland or an uncorrected adrenal gland problem that has not been treated. Your doctor will help determine if this therapy is safe for your specific health profile.

This medication can interact with other drugs, including antacids, iron supplements, and certain cholesterol medicines, which can prevent your body from absorbing it properly. You should also consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, as your dosage needs may change or require closer monitoring.

Uses of LETHYROX 88MCG TABLET

Your doctor may prescribe LETHYROX 88MCG TABLET for several thyroid-related conditions:

  • Hypothyroidism (underactive thyroid): LETHYROX 88MCG TABLET replaces the natural thyroid hormone that your body is unable to make on its own, restoring your metabolism to healthy levels.
  • Goitre (enlarged thyroid gland): This medicine helps shrink or prevent the growth of an enlarged thyroid gland by regulating the hormone levels that stimulate thyroid growth.
  • Thyroid cancer management: It is used alongside other therapies to suppress thyroid-stimulating hormone (TSH), which helps prevent certain types of thyroid cancer cells from growing back.

Key Benefits

LETHYROX 88MCG TABLET helps restore normal thyroid hormone levels, relieving the symptoms of an underactive thyroid and supporting your body's normal metabolic functions. With regular use, it improves energy levels, enhances mental clarity, and promotes overall well-being.

  • Boosts Energy and Reduces Fatigue: By restoring healthy thyroid hormone levels, this medicine helps reduce the persistent tiredness and physical weakness associated with hypothyroidism, allowing you to feel more energetic throughout the day.
  • Supports a Healthy Metabolism: This medicine helps normalise your body's metabolism, supporting stable weight management, improving tolerance to cold temperatures, and relieving symptoms such as dry skin and thinning hair.
  • Improves Mental Clarity: By correcting low thyroid hormone levels, this medicine helps reduce brain fog, forgetfulness, and difficulty concentrating, supporting better cognitive function and daily productivity.

Directions for Use

  • It should be taken on an empty stomach, 30 minutes to 1 hour before breakfast, as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow LETHYROX 88MCG TABLET as a whole with a glass of water.
  • Do not chew, crush or break it.

How LETHYROX 88MCG TABLET Works

The active ingredient, levothyroxine, in LETHYROX 88MCG TABLET is a synthetic version of thyroxine, the primary hormone produced naturally by your thyroid gland. Once you take the tablet, your body absorbs this synthetic hormone and converts it into its active form, triiodothyronine. This active hormone is what your cells and organs need to function correctly. By acting as a direct replacement for your body's missing thyroid hormone, LETHYROX 88MCG TABLET regulates how your cells use energy. It controls critical processes throughout your body, including your heart rate, body temperature, digestion, and the rate at which you burn calories. This steady replacement helps keep your body's systems running at the correct speed.
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Alcohol

Consult your doctor

The interaction of LETHYROX 88MCG TABLET with alcohol is unknown. Please consult a doctor before consuming alcohol while using LETHYROX 88MCG TABLET.

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Pregnancy

Consult your doctor

Please consult a doctor if you are pregnant. LETHYROX 88MCG TABLET is given to pregnant women if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Please consult a doctor if you are breastfeeding. Your doctor may adjust the dose appropriately if you are breastfeeding.

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Driving

Safe if prescribed

LETHYROX 88MCG TABLET usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

If you have any concerns regarding the use of LETHYROX 88MCG TABLET in patients with Liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding using LETHYROX 88MCG TABLET in patients with kidney problems, please consult a doctor.

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Children

Caution

Your doctor may adjust the dose according to your child's age, weight and other pre-existing conditions. LETHYROX 88MCG TABLET should be used for children as advised by the doctor.

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Heart

Caution

LETHYROX 88MCG TABLET should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using LETHYROX 88MCG TABLET.

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Geriatrics

Caution

LETHYROX 88MCG TABLET should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform a healthcare professional before use.

What if I have taken an overdose of LETHYROX 88MCG TABLET

If you take more than your prescribed dose, seek immediate medical attention. Symptoms of an overdose may include a rapid heart rate, severe anxiety, confusion, chest pain, sweating, or feeling extremely hot.

Diet & Lifestyle Advise

  • Avoid calcium and iron around your dose: Do not take calcium supplements, iron supplements, or antacids containing aluminium or magnesium within 4 hours of taking your thyroid medication, as they can significantly reduce its absorption.
  • Be consistent with soy and fibre: High-fibre foods, soy flour, walnuts, and grapefruit juice can lower the absorption of this medication. You do not need to avoid these foods entirely, but you should keep your intake of them consistent and talk to your doctor if you make major dietary changes.
  • Limit caffeine in the morning: Avoid drinking coffee or tea for at least 30 to 60 minutes after taking your tablet, as caffeine can interfere with how the medicine is absorbed.
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How Soon It Starts Working

The time required for LETHYROX 88MCG TABLET to start to work: The time required for LETHYROX 88MCG TABLET to show its action is unknown. The time for which the effects of LETHYROX 88MCG TABLET last: The duration of action for LETHYROX 88MCG TABLET is clinically unknown.

What if you forget to take LETHYROX 88MCG TABLET

If you miss a dose, take it as soon as you remember that day. If you do not remember until the next day, skip the missed dose and take your next regularly scheduled dose. Do not take a double dose to make up for a missed one. If you miss multiple doses in a row, talk to your doctor or pharmacist for advice.

Storage

•Store LETHYROX 88MCG TABLET tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Do not switch brands: Different brands of this medication can behave slightly differently in the body. Try to stick to the exact same brand of LETHYROX 88MCG TABLET, and consult your doctor before accepting a substitution.
  • Do not use for weight loss: This medication is not a weight loss aid. Taking excessive amounts of thyroid hormone to lose weight can cause dangerous, life-threatening side effects, especially on your heart.
  • Get regular blood tests: You will need periodic blood tests to monitor your thyroid hormone levels. This helps your doctor adjust your dose safely and ensures you are receiving the correct amount.
  • Inform other healthcare providers: Let all your doctors, dentists, and pharmacists know that you are taking LETHYROX 88MCG TABLET, especially before undergoing surgery or starting any new prescriptions.

Drug-Drug Interactions

verifiedApollotooltip
  • Antacids, calcium carbonates, and iron supplements: These can bind to the medication in your stomach and significantly decrease its absorption. Space these at least 4 hours apart from your dose.
  • Blood thinners (like warfarin): This medicine may increase the effects of blood thinners, which can increase your risk of bleeding. Your doctor may need to adjust your blood thinner dose.
  • Diabetes medications: Starting this medicine may change your blood sugar control, potentially requiring an adjustment in your insulin or oral diabetes medication doses.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • Soy, walnuts, and high-fibre foods: Consuming these in large or highly variable amounts can interfere with how well your body absorbs the medication.
  • Grapefruit juice: May slightly delay or decrease the absorption of the tablet.
LEVOTHYROXINE-88MCGCalcium rich foods
Moderate

Drug-Food Interactions

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LEVOTHYROXINE-88MCGCalcium rich foods
Moderate
Common Foods to Avoid:
Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese, Yogurt

How to manage the interaction:
Consumption of calcium supplements/calcium-rich foods, along with Lethyrox 88mcg Tablet may create an insoluble compound that affects the absorption of Lethyrox 88mcg Tablet. Avoid consumption of calcium supplements/calcium-rich foods during treatment with Lethyrox 88mcg Tablet.

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Therapeutic Class

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FAQs

LETHYROX 88MCG TABLET is used to treat hypothyroidism (underactive thyroid gland).
LETHYROX 88MCG TABLET contains Levothyroxine that works by replacing thyroxine (a thyroid hormone) naturally produced by the thyroid gland. Thus, it restores the levels of thyroid hormones.
LETHYROX 88MCG TABLET should be used with caution in diabetic patients as it may increase blood sugar levels. Therefore, inform your doctor if you have diabetes so that the dose may be adjusted appropriately.
Hair loss may occur during the first few months of treatment in children. This effect is usually temporary, and hair regrows. If this effect persists or worsens, tell your doctor for further treatment.
You are not recommended to take LETHYROX 88MCG TABLET with phenytoin (anticonvulsant) as it may reduce the effectiveness of LETHYROX 88MCG TABLET. However, please consult a doctor before taking LETHYROX 88MCG TABLET with other medicines.
LETHYROX 88MCG TABLET may cause thyroid crisis (severe reaction to high thyroid hormone levels) in some patients. However, if you experience a fast heart rate, confusion, fits, low blood pressure, jaundice, very high fever, or irregular heartbeat, please consult a doctor immediately.
No, LETHYROX 88MCG TABLET should not be used for the treatment of obesity or for weight loss. It is used to treat hypothyroidism. However, taking LETHYROX 88MCG TABLET can lead to weight loss, mainly due to losing water weight. As your thyroid hormone levels become balanced, you may expect to lose up to 10% of your body weight. This weight loss is often most noticeable when you first start the medication.
Take LETHYROX 88MCG TABLET once daily in the morning, at least 30 minutes before breakfast, or caffeinated drinks like tea or coffee. This helps your body absorb the medication properly, ensuring it works effectively. Food and caffeine can interfere with absorption, so it's best to take it on an empty stomach.
Do not stop taking LETHYROX 88MCG TABLET without talking to your doctor. Stopping it suddenly can cause recurring symptoms like fatigue, dry skin, thinning hair, and weight gain. As hypothyroidism is a chronic condition, you may need to take LETHYROX 88MCG TABLET for life. Talk to the doctor if you have any difficulties while taking LETHYROX 88MCG TABLET.
Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include fever, angina (chest pain), irregular heartbeat, headache, muscle cramps, flushing, restlessness, diarrhoea, shaking (tremors), sweating, insomnia (difficulty sleeping), and hyperpyrexia (very high temperature). If you take too much levothyroxine or experience any of these symptoms contact your doctor immediately.
You are recommended to take LETHYROX 88MCG TABLET for as long as it has been prescribed by the doctor. As hypothyroidism is a chronic condition, you may need to take LETHYROX 88MCG TABLET for life. Consult the doctor if you have any concerns regarding the duration of treatment.
Swallow it as a whole with a glass of water. Do not crush, chew, or break it.
If you are diabetic, you should be aware that LETHYROX 88MCG TABLET might raise blood sugar levels. Therefore, dose adjustment of anti-diabetic medicines may be needed. Keep your doctor informed if you are diabetic to ensure your diabetes and thyroid conditions are well-managed.
Thyroxine is a vital hormone that helps your body work properly. It regulates how your body uses energy, affects your heart rate, and helps your brain, muscles, and bones work correctly.
LETHYROX 88MCG TABLET does not affect contraception. However, combined pills which contain oestrogen may lower the amount of levothyroxine in the body. Therefore, talk to the doctor if you are taking a combined pill during treatment with LETHYROX 88MCG TABLET. Also, contraceptives may not be effective if you have vomiting or diarrhoea for over 24 hours while taking LETHYROX 88MCG TABLET.
The common side effects of LETHYROX 88MCG TABLET may include vomiting, headache, diarrhoea, restlessness, weight loss, irregular or fast heartbeat, restlessness, muscle weakness, or excitability. Most of these side effects of LETHYROX 88MCG TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
No, you should not take calcium supplements at the same time. Calcium can bind to the medication in your stomach and prevent your body from absorbing it properly. You should space calcium supplements, antacids, or calcium-rich foods at least 4 hours apart from your dose. Talk to your doctor or pharmacist if you need help scheduling your supplements.
For most people with hypothyroidism, thyroid hormone replacement therapy is a lifelong treatment because the thyroid gland cannot recover its function. However, the exact duration of treatment depends on the underlying cause of your condition. Always talk to your doctor before making any changes to your therapy.
No, you should avoid drinking coffee, tea, or any other caffeinated beverages for at least 30 to 60 minutes after taking your tablet. Caffeine can significantly reduce how much of the medication your body absorbs, which can make your treatment less effective. Talk to your doctor or pharmacist if you find it difficult to stick to this routine.
Yes, it is generally safe and crucial to continue taking this medicine during pregnancy to support both your health and your baby's development. In fact, your dosage needs will likely increase during pregnancy, so you will need regular blood tests. Talk to your doctor as soon as you know you are pregnant to manage your dosage safely.

Disclaimer

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.435 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.4305 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Levothyroxine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 021342S023Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Levothyroxine [Prescribing Information]. 2023. [Accessed on 14 Feb. 2025]Check here
  6. Levothyroxine [Prescribing Information]. 2024. [Accessed on 10 Feb. 2025]Check here
  7. Eltroxin 100mcg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 26 April 2021]Check here

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - LET0025
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