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Regestrone CR 10 mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Regestrone CR 10 mg Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Regestrone CR 10 mg Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Regestrone CR 10 mg Tablet as it may increase the levels of Regestrone CR 10 mg Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Regestrone CR 10 mg Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Regestrone CR 10 mg Tablet .

NorethisteroneTelaprevir
Severe

Drug-Drug Interactions

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NorethisteroneTelaprevir
Severe
How does the drug interact with Regestrone CR 10 mg Tablet:
Using Telaprevir and Regestrone CR 10 mg Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Regestrone CR 10 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone CR 10 mg Tablet:
Co-administration of Regestrone CR 10 mg Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Regestrone CR 10 mg Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Regestrone CR 10 mg Tablet:
Coadministration of Acitretin with Regestrone CR 10 mg Tablet may interfere with the contraceptive effect of Regestrone CR 10 mg Tablet.

How to manage the interaction:
Acitretin and Regestrone CR 10 mg Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
NorethisteroneBexarotene
Severe
How does the drug interact with Regestrone CR 10 mg Tablet:
Coadministration of Bexarotene and Regestrone CR 10 mg Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Regestrone CR 10 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone CR 10 mg Tablet:
Coadministration of Phenytoin and Regestrone CR 10 mg Tablet may decrease the blood levels of Regestrone CR 10 mg Tablet, which may make Regestrone CR 10 mg Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Regestrone CR 10 mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Regestrone CR 10 mg Tablet:
Using Felbamate and Regestrone CR 10 mg Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Regestrone CR 10 mg Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone CR 10 mg Tablet:
Taking Regestrone CR 10 mg Tablet with rifampicin can decrease the blood levels of Regestrone CR 10 mg Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Regestrone CR 10 mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneRifapentine
Severe
How does the drug interact with Regestrone CR 10 mg Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Regestrone CR 10 mg Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone CR 10 mg Tablet:
Eslicarbazepine may reduce the effects of Regestrone CR 10 mg Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Regestrone CR 10 mg Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Regestrone CR 10 mg Tablet:
Coadministration of Regestrone CR 10 mg Tablet with Fosphenytoin can reduces the blood levels and effects of Regestrone CR 10 mg Tablet .

How to manage the interaction:
Taking Regestrone CR 10 mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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