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compositionComposition:PENTOXIFYLLINE-400MG
prescription
Prescription Medicine
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Best Price

₹63 with coupons & bank offers*

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Trental 400 Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness, or weakness in the legs on walking in such patients. It works by decreasing the viscosity (thickness) of blood, allowing it to pass more easily through the blood vessels, especially in the small blood vessels of the hands and feet. It can also increase the distance you can walk without pain since it improves your legs blood circulation. It is recommended in patients whose pain has not improved even after lifestyle changes like quitting smoking and doing regular exercise. In some cases, it may cause side effects such as nausea, vomiting, diarrhoea, headache, lightheadedness, sleep problems, intrahepatic cholestasis (removal of bile from the liver is blocked), abdomen pain, constipation, and urine discolouration.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PENTOXIFYLLINE-400MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Trental 400 Tablet

Trental 400 Tablet is a prescription medication used to improve blood circulation in patients with chronic blood vessel problems. It is primarily prescribed to treat intermittent claudication, which is muscle pain, cramping, or tiredness in the legs that happens during walking. By helping blood flow more easily through narrowed vessels, it helps reduce these uncomfortable symptoms and improves your mobility.

For this medication to work effectively, you need to take it consistently and exactly as your doctor prescribes, which is typically three times a day. It is highly recommended to take your tablets with meals to prevent stomach upset or nausea. Combining this treatment with daily lifestyle adjustments, such as a structured walking program and eating a heart-healthy diet, can greatly improve your results.

While taking Trental 400 Tablet , you may experience some common, mild side effects like a mild upset stomach, gas, or occasional dizziness. However, if you experience rare but serious symptoms like chest pain, an irregular heartbeat, or unusual bleeding, you must contact your healthcare provider immediately.

Talk to your doctor before starting Trental 400 Tablet if you have a history of kidney disease, liver damage, or heart problems. Do not take this medicine if you have recently had severe bleeding in your brain or retina, as it can increase the risk of severe blood loss.

This medication can interact with other substances; for example, smoking can decrease its effectiveness by further narrowing your blood vessels, while alcohol may increase your risk of dizziness. Additionally, if you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you should discuss the risks and benefits with your doctor or pharmacist before starting treatment.

Uses of Trental 400 Tablet

Trental 400 Tablet may be prescribed for the following conditions: 

  • Intermittent claudication: Trental 400 Tablet helps ease the painful cramping, numbness, and weakness in your leg muscles that occur when walking, allowing you to walk longer distances comfortably.
  • Peripheral artery disease: It is used to manage circulation problems in the limbs by improving the flow of oxygen-rich blood through narrowed arteries.
     

Key Benefits

Trental 400 Tablet helps improve blood flow by making blood flow more easily through narrowed blood vessels. It is commonly used to reduce symptoms of poor circulation, helping improve mobility and comfort during daily activities.

  • Improves Blood Circulation: Enhances blood flow to the arms and legs by improving the flexibility of red blood cells.
  • Reduces Leg Pain While Walking: Helps relieve pain and cramping caused by poor circulation, allowing you to walk longer distances with greater comfort.
  • Supports Physical Activity: Improved circulation may make exercise and routine daily activities easier to perform.
  • Promotes Tissue Oxygen Supply: Helps improve the delivery of oxygen and nutrients to tissues affected by reduced blood flow.
  • Enhances Quality of Life: Better circulation and reduced discomfort help support greater independence and overall well-being.
Side effects of Trental 400 Mg Tab
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.

Directions for Use

  • Trental 400 Tablet can be taken with meals or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Trental 400 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Trental 400 Tablet Works

Trental 400 Tablet contains pentoxifylline, a haemorheologic agent that helps improve blood circulation. It works by making red blood cells more flexible, allowing them to pass more easily through narrow blood vessels. Pentoxifylline also reduces blood viscosity, helping blood flow more smoothly through the circulation. Through these actions, pentoxifylline improves the delivery of oxygen and nutrients to body tissues, particularly the muscles of the legs, helping to reduce pain and discomfort caused by poor blood circulation.
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Alcohol

Caution

Avoid consumption of alcohol with Trental 400 Tablet as it may increase adverse effects such as dizziness, fainting, light-headedness or headache.

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Pregnancy

Caution

Trental 400 Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Unsafe

Trental 400 Tablet is not recommended for breastfeeding mothers as it may harm the baby.

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Driving

Caution

Drive with caution, Trental 400 Tablet may cause blurry vision, and dizziness or weariness.

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Liver

Caution

Trental 400 Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Trental 400 Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Trental 400 Tablet is not recommended for children. The safety and effectiveness of Trental 400 Tablet have not been established in children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Safe if prescribed

Trental 400 Tablet can be given safely to the elderly if advised by the doctor.

What if I have taken an overdose of Trental 400 Tablet

If you take too much of this medication, you may experience symptoms like severe dizziness, flushing, fever, or fainting. Seek emergency medical attention or call your local poison control centre immediately.

Diet & Lifestyle Advise

  • Engage in a structured walking program: Regular, supervised walking exercises help your body build better natural circulation pathways over time.
  • Stop smoking: Tobacco smoke significantly narrows your blood vessels and can undo the positive effects of Trental 400 Tablet . Talk to your pharmacist about quit-smoking aids.
  • Eat a heart-healthy diet: Focus on meals low in saturated fats and cholesterol to help prevent further fat buildup in your arteries.
  • Practice daily foot care: Because poor circulation slows healing, inspect your feet daily for any cuts, blisters, or redness, and wear comfortable, supportive shoes.
     

Health Queries

How many tablets are included in ₹240?

Bayyarapu Mahesh Kumar

Bayyarapu Mahesh Kumar

M Pharmacy

The listed price may vary due to factors such as changes in MRP, ongoing offers, discounts, and other applicable promotions. Delivery charges may also vary depending on your location and order details. The final payable amount will be displayed once you add the product to your cart before placing the order.

Is Trental 400mg effective for treating poor blood circulation and sores on the toes during winter, and what alternative medications can I use since it and its substitutes are currently unavailable?

Vikas Singh

Vikas Singh

M Pharmacy

Pentoxifylline is effective for poor circulation as it helps blood flow more easily, aiding the healing of winter toe sores. Since it is currently unavailable, your doctor can recommend excellent alternatives. Calcium channel blockers, such as oral nifedipine, are highly effective options that dilate blood vessels to keep your extremities warm. Another alternative your doctor might consider is cilostazol, which also improves blood flow. Meanwhile, keep your feet warm, dry, and avoid tight footwear. Please consult your physician promptly to transition to a suitable alternative and have your sores evaluated to ensure they heal safely.

How long should I take Trental 400 mg as prescribed?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Trental 400?mg is usually taken for several weeks to months, depending on your condition and how well your symptoms improve. Your doctor will decide the exact duration; follow your doctor's instructions.

I'm a type II diabetic with foot pain and blood clotting. The prescribed Trental 400 is not available.

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

If Trental 400 is not available, you can take substitutes like Perital 400 mg or Cabaza 400mg tablet. However, it is advised to consult a doctor before substituting the medication.
health query

Have a query?

How Soon It Starts Working

The time required for Trental 400 Tablet to start to work: The time required for Trental 400 Tablet to show its action is not clinically established. The time for which the effects of Trental 400 Tablet last: The effect of Trental 400 Tablet lasts for 8 hours.

What if you forget to take Trental 400 Tablet

If you miss a dose, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the one you missed.

Storage

•Store the tablets at controlled room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the medication in its original container to protect it from moisture and direct light.

Drug Warnings

  • Swallow Extended-Release Tablets Whole: Do not crush, chew, or split extended-release tablets, as this can affect how the medicine is released.
  • Watch for Signs of Bleeding: Inform your doctor if you notice unusual bruising, prolonged bleeding, or blood in your stools or urine, especially if you are taking blood-thinning medicines.
  • Inform Healthcare Providers: Tell your doctor, dentist, or surgeon that you are taking Trental 400 Tablet before any medical, dental, or surgical procedure.
  • Stand Up Slowly: Rise gradually from a sitting or lying position to help reduce dizziness or lightheadedness.
  • Attend Regular Follow-Up Appointments: Keep all scheduled appointments so your doctor can monitor your circulation, kidney function, and overall response to treatment.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Trental 400 Tablet :

  • Blood Thinners: Medicines such as warfarin, aspirin, or other anticoagulants may increase the risk of bleeding.
  • Blood Pressure Medicines: Combining these medicines may increase the risk of low blood pressure and dizziness.
  • Diabetes Medicines: Trental 400 Tablet may occasionally enhance the blood sugar-lowering effects of antidiabetic medicines, requiring closer monitoring.
     
PentoxifyllineKetorolac
Critical

Drug-Drug Interactions

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PentoxifyllineKetorolac
Critical
How does the drug interact with Trental 400 Mg Tab:
Taking Ketorolac with Trental 400 Mg Tab can increase the risk of bleeding.

How to manage the interaction:
Taking Trental 400 Mg Tab with Ketorolac is not recommended, but can be taken together if prescribed by a doctor. However, if you experience dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness contact you doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Inform your doctor about your dietary habits and follow their recommendations during treatment.

  • High-Fat Meals: Taking Trental 400 Tablet consistently with regard to meals is recommended, as high-fat meals may affect its absorption.
  • Caffeine: Limit excessive intake of coffee, tea, energy drinks, chocolate, and other caffeinated products, as they may increase side effects such as nervousness, tremors, or a rapid heartbeat.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Trental 400 Tablet is used to treat pain in the legs due to insufficient blood flow (intermittent claudication). It also reduces cramping, numbness, or weakness in the legs when walking in such patients.
No, you should not stop taking Trental 400 Tablet even if you feel better as the pain might come back and become even worse.
No, it is a prescribed drug given by a physician to prevent specific medical conditions. Taking it on your own can cause unwanted side effects.
No. Trental 400 Tablet is not a blood thinner. It contains pentoxifylline, which improves blood flow by making red blood cells more flexible and reducing blood viscosity (thickness). This helps improve circulation and relieves symptoms such as leg pain caused by poor blood flow (intermittent claudication). Although it is not classified as a blood thinner, it may increase the risk of bleeding in some people, especially when taken with anticoagulants or antiplatelet medicines. Use it only as prescribed by your doctor.
If you forget to take Trental 400 Tablet at any time, take it as soon as you remember, then continue to take it at the usual times. Do not take a double dose to make up for a forgotten dose.
You are not recommended to take Trental 400 Tablet with warfarin as co-administration of these two medicines may increase the risk of bleeding. However, if you experience severe bleeding, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted to use safely.
It is best to limit or avoid alcohol while taking this medicine, as alcohol can increase side effects like dizziness, lightheadedness, and flushing. Talk to your doctor or pharmacist for personalised advice.
You should always take Trental 400 Tablet with food or a meal. This helps protect your stomach lining and reduces common side effects like nausea and indigestion.
No, Trental 400 Tablet does not cure peripheral artery disease or blood circulation issues; it helps manage your symptoms so you can walk farther with less pain. You should continue taking it as long as your doctor recommends.
If you feel dizzy, sit or lie down immediately. Stand up slowly when rising from a sitting or lying position, and avoid driving or operating machinery until the dizziness passes. If it persists, talk to your doctor.
No, you must swallow the tablet whole. Crushing, chewing, or splitting the tablet destroys its special slow-release mechanism, which can cause too much medicine to enter your body at once.
The safety of Trental 400 Tablet during pregnancy has not been fully established. If you are pregnant or planning to become pregnant, talk to your doctor to weigh the benefits against potential risks.
Yes, Trental 400 Tablet can slightly increase your risk of bleeding, especially if you take it with blood thinners or have an underlying bleeding disorder. Watch for signs like nosebleeds or easy bruising, and report them to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.
Other Info - TRE0004
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