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Biotrexate 15Mg Inj belongs to the class of antimetabolite medications used in the treatment of polyarticular juvenile rheumatoid arthritis, psoriasis, and cancer. It contains Methotrexate, which works by interfering with the immune system process that causes inflammation and prevents the growth of cancer-causing cells. This medicine may cause side effects like nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, and loss of appetite. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Side effects of Biotrexate 15 mg Injection
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Etretinate with Biotrexate 15 mg Injection may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Biotrexate 15 mg Injection is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Taking tacrolimus with Biotrexate 15 mg Injection may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between tacrolimus and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Benzylpenicillin with Biotrexate 15 mg Injection may increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction, Biotrexate 15 mg Injection can be taken with Benzylpenicillin if prescribed by the doctor. Consult the prescriber if you experience any symptoms such as fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body aches. Contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Coadministration of Biotrexate 15 mg Injection with ketorolac can increase the blood levels and side effects of Biotrexate 15 mg Injection.

How to manage the interaction:
Although there is a interaction between Biotrexate 15 mg Injection and ketorolac, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Baricitinib and Biotrexate 15 mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Baricitinib and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination. Consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
The combined use of entecavir with Biotrexate 15 mg Injection may increase levels of Entecavir, and increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between entecavir and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Acitretin with Biotrexate 15 mg Injection may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Biotrexate 15 mg Injection, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Biotrexate 15 mg Injection with pantoprazole can increase the levels and side effects of Biotrexate 15 mg Injection.

How to manage the interaction:
Although there is a possible interaction between pantoprazole and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Biotrexate 15 mg Injection:
Co-administration of Biotrexate 15 mg Injection with etanercept can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between etanercept and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateProcaine benzylpenicillin
Severe
How does the drug interact with Biotrexate 15 mg Injection:
Coadministration of Biotrexate 15 mg Injection with procaine benzyl penicillin can increase the levels and side effects of Biotrexate 15 mg Injection.

How to manage the interaction:
Although there is a possible interaction between procaine benzyl penicillin and Biotrexate 15 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms, consult your doctor. Do not stop using any medications without consulting to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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