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compositionComposition:METHOTREXATE-50MG
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Plastomet-50 Injection 2 ml belongs to the class of antimetabolite medications used in the treatment of polyarticular juvenile rheumatoid arthritis, psoriasis, and cancer. It contains Methotrexate, which works by interfering with the immune system process that causes inflammation and prevents the growth of cancer-causing cells. This medicine may cause side effects like nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, and loss of appetite. Inform your doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

METHOTREXATE-50MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Plastomet-50 Injection 2 ml

Plastomet-50 Injection 2 ml is a prescription injection used to treat severe rheumatoid arthritis, severe psoriasis, and certain types of cancer. It is prescribed when other standard treatments have not provided sufficient relief or when rapid disease control is necessary.

To achieve the best results, this medication must be used with strict consistency. It is typically injected only once a week, and keeping a regular, weekly schedule is crucial for both safety and effectiveness. Since it is an injection, food intake does not alter how your body processes it, but maintaining a balanced diet, avoiding alcohol, and limiting sun exposure can help support your body during treatment.

While highly effective, Plastomet-50 Injection 2 ml can cause some common side effects, such as mild nausea, temporary hair thinning, or minor mouth sores. However, you must contact your healthcare provider immediately if you experience serious symptoms like a high fever, persistent cough, or yellowing of your skin or eyes.

Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as it can cause severe harm to an unborn baby. Before starting, talk to your doctor if you have a history of liver disease, kidney problems, active infections, or blood disorders.

Plastomet-50 Injection 2 ml can interact with alcohol, smoking, and certain pain relievers, which can increase the risk of serious liver or lung complications. Special care and close monitoring are required for elderly individuals, as their kidneys may process the medication more slowly. Talk to your doctor or pharmacist to discuss your full list of medications before starting treatment.

Uses of Plastomet-50 Injection 2 ml

Plastomet-50 Injection 2 ml helps control certain autoimmune diseases and cancers by slowing the growth of abnormal cells and reducing immune system activity. Your doctor may recommend it for the following conditions:

  • Rheumatoid Arthritis: Helps reduce joint pain, swelling, and stiffness by calming an overactive immune system, preventing long-term joint damage.
  • Severe Psoriasis: Slows down the rapid growth of skin cells, helping to clear up red, scaly patches and restore comfort.
  • Certain Cancers: Slows or stops the growth of rapidly dividing cancer cells in the body.

Key Benefits

Plastomet-50 Injection 2 ml helps control disease activity, relieve symptoms, and improve quality of life in people with certain autoimmune conditions and cancers. Key benefits include:

  • Relieves joint symptoms: Helps reduce joint pain, swelling, and morning stiffness, making daily activities easier and more comfortable.
  • Helps protect joints: By controlling the underlying disease, it helps reduce the risk of long-term joint damage and physical deformity.
  • Improves skin health: Helps clear painful or itchy psoriatic plaques, improving skin texture and reducing discomfort.
  • Convenient treatment schedule: As a once-weekly injection, it offers a convenient dosing routine that may help improve treatment adherence.
Side effects of Plastomet-50 Injection 2 ml
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Plastomet-50 Injection 2 ml will be administered by the doctor.
  • Do not self-administer.

How Plastomet-50 Injection 2 ml Works

Plastomet-50 Injection 2 ml contains methotrexate, which targets rapidly growing cells in the body. In autoimmune diseases such as rheumatoid arthritis and psoriasis, the body's immune system mistakenly attacks its own healthy tissues, causing chronic inflammation. It works by blocking specific enzymes that these overactive immune cells need to grow and multiply. By slowing this overactive immune response, it helps reduce inflammation, protect the joints from damage, and slow the abnormally rapid buildup of skin cells.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Plastomet-50 Injection 2 ml.

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Pregnancy

Unsafe

Plastomet-50 Injection 2 ml may cause serious birth defects. It is not recommended to take Plastomet-50 Injection 2 ml while you are pregnant.

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Breast Feeding

Unsafe

Plastomet-50 Injection 2 ml passes into breast milk. Avoid breastfeeding whilst on treatment with Plastomet-50 Injection 2 ml and for at least 1 week after the last dose.

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Driving

Caution

Plastomet-50 Injection 2 ml may cause dizziness and tiredness; do not drive or operate heavy machinery until you know how Plastomet-50 Injection 2 ml affects you.

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Liver

Caution

Please consult your doctor if you have liver impairment before receiving Plastomet-50 Injection 2 ml.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before receiving Plastomet-50 Injection 2 ml.

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Children

Caution

The efficacy and safety of Plastomet-50 Injection 2 ml in children have been established in polyarticular-course juvenile rheumatoid arthritis and cancer chemotherapy. Please consult your doctor if you have any concerns regarding the usage of Plastomet-50 Injection 2 ml in children.

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Heart

Caution

Plastomet-50 Injection 2 ml can be used in heart patients and may even provide cardiovascular benefits. However, it should be administered under medical supervision due to potential side effects and drug interactions.

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Geriatrics

Caution

Plastomet-50 Injection 2 ml can be used in geriatric patients, but with caution due to increased sensitivity to side effects like liver toxicity and bone marrow suppression. Regular monitoring and dose adjustments are essential to ensure safe use.

What if I have taken an overdose of Plastomet-50 Injection 2 ml

If you think you have injected more than the prescribed dose of Plastomet-50 Injection 2 ml or used it more frequently than prescribed (such as more than once a week), seek immediate medical attention. Symptoms of an overdose may vary depending on the amount used and the individual. Prompt medical evaluation is recommended in all suspected cases.

Diet & Lifestyle Advise

  • Take Folic Acid: Your doctor will likely prescribe a folic acid supplement. This B-vitamin helps protect healthy cells and reduces common side effects like mouth sores and nausea. Take it exactly as directed, usually on the days you do not receive your injection.
  • Avoid Alcohol: Do not drink alcohol while using this medicine, as the combination significantly increases the risk of severe liver damage.
  • Protect Your Skin: This medication makes your skin highly sensitive to sunlight. Wear protective clothing, a wide-brimmed hat, and apply a broad-spectrum sunscreen with SPF 30 or higher when outdoors.
  • Stay Well-Hydrated: Drink plenty of water, especially on the day of your injection, to help your kidneys flush the medication out of your system safely.
  • Practice Good Hygiene: Because this medicine can lower your white blood cell count and weaken your immune system, wash your hands frequently and avoid close contact with individuals who have active infections.
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How Soon It Starts Working

The time required for Plastomet-50 Injection 2 ml to start to work: Plastomet-50 Injection 2 ml ideally shows its action within 30 to 60 minutes after administration.

The time for which the effects of Plastomet-50 Injection 2 ml last: The effect of Plastomet-50 Injection 2 ml lasts for 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.

What if you forget to take Plastomet-50 Injection 2 ml

If you miss your weekly injection, contact your doctor or pharmacist immediately for guidance on when to take your next dose. Do not inject a double dose to make up for a missed one.

Storage

• Store Plastomet-50 Injection 2 ml at room temperature between 20°C and 25°C (68°F to 77°F). Keep it away from direct heat and do not freeze.

Drug Warnings

  • Inspect the Liquid: Always check the solution before injecting. It should be clear and yellow to brown-yellow. Do not use it if it is cloudy, contains floating particles, or looks discoloured.
  • Rotate Injection Sites: Choose a different spot (such as alternating thighs or sides of the abdomen) for each weekly injection to reduce skin irritation.
  • Never Reuse Needles: Use a sterile needle and syringe or pre-filled pen only once, then discard it immediately in your sharps container to prevent infections.
  • Avoid Live Vaccines: Talk to your doctor before getting any immunisations. Avoid live vaccines (such as those for shingles or yellow fever) while on this treatment, as your immune system may not react safely to them.
  • Strict Weekly Schedule: Always remember that this medication is injected only once a week. Taking it daily can lead to severe, life-threatening complications.

Drug-Drug Interactions

verifiedApollotooltip
  • Pain Relievers: Using certain pain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), alongside this injection can increase the levels of the medicine in your blood, raising the risk of severe side effects.
  • Antibiotics: Certain antibiotics (such as penicillins or trimethoprim) can interfere with how your kidneys clear this medicine, increasing its toxicity.
  • Acid-Reflux Medications: Proton pump inhibitors (PPIs) may delay the clearance of this medicine from your body, potentially increasing the risk of adverse reactions.
MethotrexateEtretinate
Critical
MethotrexateIndometacin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Etretinate with Plastomet-50 Injection 2 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Plastomet-50 Injection 2 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateIndometacin
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Plastomet-50 Injection 2 ml with Indomethacin can increase the levels and side effects of Plastomet-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between Plastomet-50 Injection 2 ml and Indomethacin, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms like mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, breathing difficulty, a dry cough, dizziness or fainting, unusual bruising or bleeding, seizures(fits), infection, as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateClozapine
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Plastomet-50 Injection 2 ml with clozapine may increase the risk or severity of clozapine side effects.

How to manage the interaction:
Although there is a possible interaction between clozapine and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Coadministration of Everolimus with Plastomet-50 Injection 2 ml can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Plastomet-50 Injection 2 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateTofacitinib
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Coadministration of Plastomet-50 Injection 2 ml with tofacitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between tofacitinib and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateCladribine
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Plastomet-50 Injection 2 ml with cladribine can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between cladribine and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, and pain or burning during urination, Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateRabeprazole
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Plastomet-50 Injection 2 ml with Rabeprazole can increase the blood levels and side effects of Plastomet-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between Rabeprazole and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateMeloxicam
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Meloxicam with Plastomet-50 Injection 2 ml may increase the levels and side effects of Meloxicam.

How to manage the interaction:
Although there is a possible interaction between meloxicam and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateEsomeprazole
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Co-administration of Plastomet-50 Injection 2 ml and esomeprazole can increase the blood levels and side effects of Plastomet-50 Injection 2 ml.

How to manage the interaction:
Although taking Esomeprazole with Plastomet-50 Injection 2 ml can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.
MethotrexateTenofovir alafenamide
Severe
How does the drug interact with Plastomet-50 Injection 2 ml:
Combine use of tenofovir alafenamide with Plastomet-50 Injection 2 ml may increase the levels or side effects of tenofovir alafenamide.

How to manage the interaction:
Although there is a possible interaction between tenofovir alafenamide and Plastomet-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Limit excessive consumption of coffee, black tea, or caffeinated sodas, as high amounts of caffeine may reduce the effectiveness of this medicine in treating arthritis.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIMETABOLITES, IMMUNOSUPPRESSANTS]

FAQs

Yes, you can inject it at any time on your scheduled weekly day, but it is best to keep the timing consistent. Some patients prefer injecting it in the evening or over the weekend so they can sleep through any initial mild nausea or tiredness. Talk to your doctor or pharmacist to establish the best routine for you.
This medicine can lower the levels of folate in your body, which healthy cells need to function. Taking a prescribed folic acid supplement helps protect your healthy cells, which significantly reduces common side effects like mouth sores, nausea, and liver enzyme changes. Talk to your doctor about your specific folic acid schedule.
No, you must not get pregnant or father a child while using this medicine, as it can cause severe birth defects or pregnancy loss. Both men and women must use highly reliable birth control during treatment and for a specific time after stopping it. Talk to your doctor immediately if you are planning a family.
No, you should avoid alcohol completely while on this medication. Both alcohol and this medicine are processed by the liver, and combining them significantly increases your risk of severe, irreversible liver damage. Talk to your doctor or pharmacist if you have concerns about this restriction.
Mild, temporary hair thinning can occur in some people. In most cases, taking your prescribed folic acid supplement helps manage this side effect, and hair typically grows back normally once the treatment is adjusted or stopped. Talk to your doctor if the hair loss becomes highly bothersome or severe.
Yes, you can travel with your medication. Keep your pre-filled pens or vials in their original packaging with the prescription label clearly visible, and store them at room temperature away from extreme heat or freezing. Carry a travel-safe sharps container for disposal. Talk to your doctor or pharmacist for a travel letter if you are flying.
Regular blood tests are necessary to monitor your liver function, kidney health, and blood cell counts. This allows your doctor to make sure the medicine is working safely and helps them adjust your dose before any serious, unseen side effects develop. Talk to your doctor to understand your testing schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A682018 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 011719S117Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Methotrexate [Prescribing Information]. 2020. [Accessed on 19 Apr. 2023]Check here
  4. Methotrexate [Prescribing Information]. 2023. [Accessed on 26 Feb. 2025]Check here
  5. Webmed.methotrexate. 2025 [Accessed on 5th Dec 2025]Check here
  6. Ema.methotrexate. 2025 [Accessed on 5th Dec 2025]Check here
  7. Lactmed.methotrexate. 2025 [Accessed on 5th Dec 2025] Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Methotrexate. [Updated 2018 Oct 31]Check here

Country of origin

India

Manufacturer/Marketer address

87, Dattaram Lad Path, Ghodapdeo, Byculla East, Parel, Mumbai, Maharashtra 400 033.
Other Info - PLA0454
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