Do not take BIOTREXATE 50MG INJECTION 2ML if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. BIOTREXATE 50MG INJECTION 2ML may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive BIOTREXATE 50MG INJECTION 2ML while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Drug-Drug Interactions: BIOTREXATE 50MG INJECTION 2ML may have interaction with pain killers/NSAIDs, an antineoplastic agent (cisplatin), immunosuppressants (mercaptopurine, azathioprine), antibiotics (tetracycline, chloramphenicol), anti-inflammatory agents (sulfasalazine), retinoids.

Drug-Food Interactions: Avoid consuming alcohol whilst on treatment with BIOTREXATE 50MG INJECTION 2ML. 

Drug-Disease Interactions: Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, or chronic liver disease.

Arthritis:

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

Psoriasis:

• Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
• Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
• Avoid processed foods, refined sugars, and fatty foods.
• Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
• Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
• Reducing stress and maintaining a good sleep cycle would be helpful.
• Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

• Consume a healthy diet and exercise regularly to maintain proper weight.
• Avoid smoking and alcohol consumption.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
• Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
• Get optimal sleep; rest well.

• Women of child-bearing potential must use effective contraception whilst on treatment with BIOTREXATE 50MG INJECTION 2ML and for at least 6 months after the last dose.
• If you are a male, you and your partner should use reliable contraception during treatment with BIOTREXATE 50MG INJECTION 2ML and for at least 3 months after the last dose.
• BIOTREXATE 50MG INJECTION 2ML may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
• Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.