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compositionComposition:LEFLUNOMIDE-10MG
prescriptionPrescription Medicine
Lefra 10 Tablet 10's
Lefra 10 Tablet 10's
Lefra 10 Tablet 10's

Lefra 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEFLUNOMIDE-10MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lefra 10 Tablet

Lefra 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis and Psoriatic arthritis are autoimmune diseases characterised by joint inflammation, stiffness, and pain.

Lefra 10 Tablet contains 'Leflunomide', an isoxazole immunomodulatory agent which works by suppressing the activated immune system. Thereby, it helps reduce pain, inflammation and swelling. 

In some cases, Lefra 10 Tablet may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Do not take Lefra 10 Tablet if you are pregnant or planning for pregnancy, as Lefra 10 Tablet may cause serious congenital disabilities. Lefra 10 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefra 10 Tablet may cause dizziness, so drive with caution.

Uses of Lefra 10 Tablet

Lefra 10 Tablet is used in the treatment of Rheumatoid arthritis and Psoriatic arthritis. The detailed uses of Lefra 10 Tablet are as follows:

  • Rheumatoid Arthritis (RA): Lefra 10 Tablet reduces joint pain, swelling, and stiffness; slows progression of joint damage.
  • Psoriatic Arthritis: Lefra 10 Tablet eases symptoms like joint inflammation and skin lesions associated with psoriasis.

Have a query?

Directions for Use

  • Take Lefra 10 Tablet with or without food as advised by your doctor.
  • It is usually taken once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Lefra 10 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Key Benefits

  • Lefra 10 Tablet relieves symptoms of rheumatoid arthritis and psoriatic arthritis.
  • It inhibits dihydroorotate dehydrogenase, reducing excessive immune cell activity.
  • It has antiproliferative properties, helping suppress abnormal cell growth.
  • Lefra 10 Tablet reduces inflammation, redness, pain, and swelling in affected joints.
  • It improves joint function and mobility, enhancing the quality of life in arthritis patients.

How Lefra 10 Tablet Works

Lefra 10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

Store in a cool and dry place away from sunlight
Side effects of Lefra 10 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Lefra 10 Tablet

Do not take more than the prescribed dose of Lefra 10 Tablet as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Lefra 10 Tablet if you are allergic to leflunomide, have severe liver or kidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections.
  • Lefra 10 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age.
  • Talk to your doctor before taking Lefra 10 Tablet if you have/had serious infections like interstitial lung disease (inflammation of the lungs), tuberculosis (TB), or pneumonia.
  • Lefra 10 Tablet may cause dizziness, so drive with caution.
  • Lefra 10 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Inform your doctor if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
LeflunomideDanazol
Severe
LeflunomidePrasterone
Severe

Drug-Drug Interactions

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LeflunomideDanazol
Severe
How does the drug interact with Lefra 10 Tablet:
Combining Lefra 10 Tablet with Danazol may increase the risk of liver problems.

How to manage the interaction:
Although taking Danazol and Lefra 10 Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomidePrasterone
Severe
How does the drug interact with Lefra 10 Tablet:
Taking Lefra 10 Tablet with prasterone may increase the risk of liver problems.

How to manage the interaction:
Taking Prasterone with Lefra 10 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTerbinafine
Severe
How does the drug interact with Lefra 10 Tablet:
Co-administration of Lefra 10 Tablet and Terbinafine can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Lefra 10 Tablet and terbinafine, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideClozapine
Severe
How does the drug interact with Lefra 10 Tablet:
The combined use of Lefra 10 Tablet and clozapine may increase the risk of neutropenia (low white blood cell count)

How to manage the interaction:
There may be a possibility of interaction between Lefra 10 Tablet and Clozapine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideIbuprofen
Severe
How does the drug interact with Lefra 10 Tablet:
The combined use of Lefra 10 Tablet and Ibuprofen can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Lefra 10 Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideCertolizumab
Severe
How does the drug interact with Lefra 10 Tablet:
Combining Certolizumab pegol with Lefra 10 Tablet can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Lefra 10 Tablet with Certolizumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, contact your doctor right away. These symptoms include feeling tired, dizzy, or lightheaded, having pale skin, experiencing frequent bleeding or bruising, having a fever or chills, having diarrhea or a sore throat, feeling muscle aches, having trouble breathing, losing weight unexpectedly, or feeling pain or burning when you urinate. Do not discontinue any medications without consulting your doctor.
LeflunomideBenazepril
Severe
How does the drug interact with Lefra 10 Tablet:
Lefra 10 Tablet can cause liver issues, and combining it with other drugs, such as benazepril, can enhance the risk.

How to manage the interaction:
Co-administration of Lefra 10 Tablet with Benazepril can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or feeling sick, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
LeflunomideAdalimumab
Severe
How does the drug interact with Lefra 10 Tablet:
Taking adalimumab with Lefra 10 Tablet can increase the risk of side effects.

How to manage the interaction:
Although taking Lefra 10 Tablet and Adalimumab together can cause an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideAldesleukin
Severe
How does the drug interact with Lefra 10 Tablet:
Taking aldesleukin with Lefra 10 Tablet can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between Lefra 10 Tablet and aldesleukin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideTizanidine
Severe
How does the drug interact with Lefra 10 Tablet:
Coadministration of tizanidine and Lefra 10 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Lefra 10 Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

[ANTIRHEUMATICS]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefra 10 Tablet . Alcohol intake, along with Lefra 10 Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefra 10 Tablet while you are pregnant. Lefra 10 Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefra 10 Tablet while you are breastfeeding. Lefra 10 Tablet passes into breast milk.

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Driving

Caution

Lefra 10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking Lefra 10 Tablet .

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Lefra 10 Tablet .

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Children

Unsafe

Lefra 10 Tablet is not approved for children under the age of 18 years.

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Heart

Unsafe

Avoid taking Lefra 10 Tablet if you have any cardiac problems. If prescried, caution should be exercised while taking Lefra 10 Tablet .

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Geriatrics

Consult your doctor

Please consult a doctor before giving Lefra 10 Tablet to geriatric patients.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - LEF0001

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