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Linezolid Tablet is an antibiotic medication used to treat bacterial infections of the skin and soft tissues, lungs (pneumonia) and bloodstream infections. It is also used to treat infections that are resistant to other antibiotics, such as vancomycin-resistant enterococcal infections.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Drug-Drug Interactions

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Drug-Drug Interactions: Inform your doctor if you are taking any of these medicines, as there may be an interaction.

  • Antidepressant drugs (citalopram, amitriptyline)
    Potential effect: May increase the risk of side effects like agitation, confusion, increased blood pressure, and tremors.
  • Antiallergic drugs (epinephrine)
    • Potential effect: May increase the effects of elevated blood pressure
  • Antimigraine medications (sumatriptan)
    Potential effect: May increase the risk of serotonin syndrome (a medical condition which occurs due to high levels of serotonin intake)

Drug-Food Interactions: Avoid foods and drinks containing tyramine, such as cheese, yeast extracts, soybean extracts, alcohol, beer, or wine while taking Linezolid Tablet , as it may interact with tyramine and lead to an increase in blood pressure.

Drug-Disease Interactions: Inform your doctor if you have a history of the following conditions before taking Linezolid Tablet , as it may worsen your condition or cause complications.

  • Colitis (inflammation in the lining of the colon)
  • Seizures
  • High blood pressure
  • Hypoglycaemia (low blood sugar levels)
  • Kidney or liver disease.

Drug-Drug Interactions

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How does the drug interact with Linezolid Tablet Tablet:
When Vilazodone is taken with Linezolid Tablet, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Vilazodone with Linezolid Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as severe confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Linezolid Tablet with Epinephrine can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid Tablet with Epinephrine is not recommended as it can result in an interaction. It should be taken only if a doctor has advised it. However, if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Safinamide with Linezolid Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safinamide with Linezolid Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and loose stools, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Linezolid Tablet with Amitriptyline can increase the risk of serotonin syndrome (increased serotonin hormone).

How to manage the interaction:
Although using Linezolid Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Using Linezolid Tablet together with mirtazapine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Linezolid Tablet with Mirtazapine can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Linezolid Tablet Tablet:
When Linezolid Tablet is taken with Sertraline, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
taking Linezolid Tablet and Sertraline is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, and diarrhoea-contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Linezolid Tablet Tablet:
Co-administration of Linezolid Tablet with Tramadol can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid Tablet with Tramadol is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Do not stop using any medications without talking to a doctor.
How does the drug interact with Linezolid Tablet Tablet:
Taking Linezolid Tablet with Fentanyl may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Linezolid Tablet and Fentanyl, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Linezolid Tablet Tablet:
Combining Linezolid Tablet with Buspirone can increase the risk of high blood pressure.

How to manage the interaction:
Taking Buspirone with Linezolid Tablet is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice
How does the drug interact with Linezolid Tablet Tablet:
When Clomipramine is taken with Linezolid Tablet, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clomipramine and Linezolid Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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LINEZOLID-600MGTyramine-containing food
Severe

Drug-Food Interactions

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LINEZOLID-600MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Taking high tyramine-containing food along with Linezolid Tablet can cause blood pressure to rise to exceedingly high levels, a condition known as a hypertensive crisis (Severely elevated blood pressure). Avoid high tyramine-containing food while taking Linezolid Tablet. Consult a doctor, if you experience severe headache, confusion, blurred vision, problems with speech or balance, nausea, vomiting, chest pain, convulsions, and sudden numbness or weakness (especially on one side of the body).

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