Safinamide

• If you are known to be allergic to Safinamide or any other medicines, please tell your doctor.
• Please inform your doctor if you are using any medications other than Safinamide.
• If you are pregnant or breastfeeding, it is advised to inform your doctor.
• Safinamide is not recommended in albinism (a condition with less melanin) and eye problems like retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy.
• Safinamide should be used with caution in patients with schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems.
• Safinamide may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour. Hence, talk to your doctor if you are taking any of these medicines.

Drug-Drug Interaction: Inform your doctor if you are taking any of these medicines, as there may be an interaction.

• Antidepressant (Doxepin, Imipramine)
  • Potential effect: May increase the risk of serotonin syndrome (a serious drug reaction)

Drug-Food Interaction: Safinamide may interact with foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats, fish, and meats that are aged, dried, smoked, or fermented meats. Avoid consuming tyramine-rich foods while taking Safinamide, as it may increase blood pressure levels.

Drug-Disease Interaction: Inform your doctor if you have any of these conditions.

• Albinism (a condition with little or no pigment in the skin, hair, and eyes)
• Retinal degeneration
• Uveitis (eye inflammation)
• Inherited retinopathy (inherited eye problem)
• Severe progressive diabetic retinopathy (eye damage caused by long-term diabetes that worsens over time)

Balanced Nutrition:

• Follow a balanced diet that includes grains and leafy vegetables rich in vitamins, fibre, and minerals.
• Include dairy products, protein-rich foods such as beans and meat, and healthy fats from nuts, olive oil, fish, and eggs.
• Limit the consumption of sugar to support overall health.

Protein Intake Management:

• Avoid excessive intake of high-protein foods such as soy protein, fish, eggs, chicken, beef, and pork.
• Prefer whole-grain foods like whole wheat bread, oatmeal, brown rice, and whole-grain pasta.

Digestive Health:

• Eat more fibre-rich foods to help relieve constipation.

Hydration:

• Drink plenty of water to prevent dehydration-related headaches.

• Talk to your doctor if you develop hallucinations or other changes in your behaviour.