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Zafimove 100 Tablet is used in the treatment of Parkinson’s disease to help manage symptoms such as stiffness, tremors, and difficulty in movement. It helps improve motor control and supports smoother body movements, thereby enhancing daily functioning and quality of life in patients with Parkinson’s disease.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SAFINAMIDE-100MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Zafimove 100 Tablet

Zafimove 100 Tablet is an oral prescription medication used to treat Parkinson's disease. Specifically, it is prescribed as an add-on treatment for people who are already taking levodopa and carbidopa and are experiencing off episodes, which are periods when their regular medication wears off, and symptoms return.

To get the best results, you must take Zafimove 100 Tablet consistently at the same time every single day. You can take this medication with or without food, depending on your preference. Making certain lifestyle changes, such as eating a balanced diet, staying active, and participating in physical therapy, can also support your overall physical function and mobility.

While taking Zafimove 100 Tablet , some people may experience mild side effects like nausea or trouble sleeping. However, you must contact your doctor immediately if you notice serious symptoms, such as severe uncontrolled muscle movements, changes in your vision, or sudden, severe headaches.

Talk to your doctor before starting Zafimove 100 Tablet if you have liver problems, as this condition can affect how your body clears the medicine. Do not take this if you have severe liver damage, or if you are currently taking other monoamine oxidase inhibitors or certain antidepressants.

This medicine can interact with other drugs, including over-the-counter cough medicines and strong pain relievers, which can cause dangerous increases in blood pressure. Avoid drinking alcohol while taking this medicine, and consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are an elderly individual.

Uses of Zafimove 100 Tablet

Zafimove 100 Tablet used in the treatment of Parkinson's disease. The detailed uses of Zafimove 100 Tablet are as follows:

  • Parkinson's disease: Zafimove 100 Tablet helps by extending the active time of your primary Parkinson's medications, reducing the daily periods when your movement symptoms return or worsen.
  • Movement control difficulties: It helps manage motor symptoms such as tremors, stiffness, and slowness of movement by stabilising chemical levels in the brain.

Key Benefits

Zafimove 100 Tablet helps improve movement in people with Parkinson's disease by reducing periods when symptoms return between doses of their regular medication.

The following are the benefits of Zafimove 100 Tablet :

  • Helps reduce 'off' periods between Parkinson's medication doses.
  • Increases the amount of time with better symptom control.
  • Improves movement and the ability to perform daily activities.
  • Reduces stiffness and movement difficulties.
  • Supports smoother control of Parkinson's symptoms throughout the day.
  • Promotes greater independence and overall quality of life.
Side effects of Zafimove 100 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Pounding in the ears needs immediate medical attention when you hear abnormal sounds through your ears.
  • Get a physical examination, and an ENT will help identify factors that led to ear pounding.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and use a white noise machine to reduce the pounding sound in your ear. Soft music and low-volume radio can also help if there is no white noise machine.
  • Take a balanced diet and limit your intake of caffeine, alcohol and nicotine.

Directions for Use

  • Zafimove 100 Tablet can be taken with or without food, but it is best to take it at the same time every day to establish a consistent routine.
  • Swallow Zafimove 100 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.
  • Always follow your doctor's exact instructions regarding how to take this medicine, and do not change your dose or stop taking it without consulting them first.

How Zafimove 100 Tablet Works

Zafimove 100 Tablet contains safinamide, which works by helping your brain maintain higher, more consistent levels of dopamine, which is a natural chemical messenger responsible for controlling smooth and coordinated muscle movements. In Parkinson's disease, the brain lacks a sufficient amount of this chemical. This medicine works by blocking a specific enzyme in the brain called monoamine oxidase type B (MAO-B). This enzyme is normally responsible for breaking down dopamine. By stopping this breakdown process, Zafimove 100 Tablet allows the dopamine produced by your other Parkinson's medications to last longer and work more effectively in your body. It also helps regulate other overactive chemical signals in the brain, helping to steady your movements.
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Alcohol

Caution

Zafimove 100 Tablet may cause excessive drowsiness with alcohol, decreasing alertness and affecting your vision.

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Pregnancy

Unsafe

Zafimove 100 Tablet may be unsafe to use during pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Zafimove 100 Tablet . Please consult your doctor before taking Zafimove 100 Tablet .

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Breast Feeding

Unsafe

Zafimove 100 Tablet may be unsafe to use in breastfeeding mothers. Your doctor will weigh the benefits and potential risks before prescribing Zafimove 100 Tablet . Please consult your doctor before taking Zafimove 100 Tablet .

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Driving

Caution

Zafimove 100 Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Zafimove 100 Tablet should be used with caution in patients with liver disease. A dose adjustment of Zafimove 100 Tablet may be needed. So please consult your doctor before taking Zafimove 100 Tablet .

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Kidney

Caution

Zafimove 100 Tablet should be used with caution in patients with kidney disease. A dose adjustment of Zafimove 100 Tablet may be needed. So please consult your doctor before taking Zafimove 100 Tablet .

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Children

Unsafe

Zafimove 100 Tablet is not recommended for use in children under 12 years.

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Heart

Caution

Zafimove 100 Tablet should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Zafimove 100 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Zafimove 100 Tablet

If you suspect an overdose or have taken more than your prescribed dose, seek immediate medical attention or contact your local emergency services right away.

Diet & Lifestyle Advise

  • Watch your protein intake timing: High-protein meals (such as meat, dairy, or fish) can interfere with how your body absorbs your primary Parkinson's medication. Try to space out high-protein foods, so you do not eat them at the same time you take your dose.
  • Be cautious with tyramine-rich foods: Consuming very large amounts of foods high in tyramine (such as aged cheeses, air-dried or cured meats, and red wine) can sometimes affect your blood pressure. Speak with your doctor about whether you need to limit these items.
  • Prevent falls: Because Parkinson's disease and its treatments can cause dizziness when standing up, always rise slowly from sitting or lying positions, and keep your walkways clear of clutter.
  • Stay hydrated: Drink plenty of water throughout the day to help manage dry mouth, support digestion, and prevent sudden drops in blood pressure when you stand up.
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How Soon It Starts Working

  • The time required for Zafimove 100 Tablet to start to work: Zafimove 100 Tablet ideally shows its action within 2 to 3 hours after administration.
  • The time for which the effects of Zafimove 100 Tablet last: The effect of Zafimove 100 Tablet lasts for 24 hours.

What if you forget to take Zafimove 100 Tablet

If you miss a dose of Zafimove 100 Tablet , skip the missed dose and take your next scheduled dose the following day at your usual time. Do not take two doses at the same time to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Zafimove 100 Tablet out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check your blood pressure regularly: Because this medication can influence your blood pressure, keep a home log of your readings and report any sudden, high spikes to your healthcare team.
  • Avoid driving if you feel excessively sleepy: If you experience severe daytime drowsiness or find yourself falling asleep suddenly during normal activities, do not drive or operate machinery, and inform your doctor immediately.
  • Monitor for eye health changes: If you have a history of retinal disease or experience any sudden changes in your vision, schedule an eye exam promptly.
  • Watch for new involuntary movements: Report any new or worsening muscle spasms or twitching to your doctor, as your other Parkinson's medications may need to be adjusted.
  • Do not stop taking this medicine suddenly: Abruptly stopping Zafimove 100 Tablet can cause your Parkinson's symptoms to return severely. Always talk to your doctor before making any changes.

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants and monoamine oxidase inhibitors (MAOIs) (e.g., sertraline, amitriptyline, phenelzine): Taking Zafimove 100 Tablet with other MAO inhibitors or certain antidepressants can cause a life-threatening buildup of serotonin or a severe spike in blood pressure.
  • Cough and pain medications (e.g., dextromethorphan, tramadol): Combining Zafimove 100 Tablet with cough medicines or strong pain relievers can increase the risk of serious neurological side effects.

Drug-Drug Interactions

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How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet and Methyldopa together can increase the risk of high blood pressure or brain related problems.

How to manage the interaction:
Taking Zafimove 100 Tablet with Methyldopa is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Venlafaxine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Venlafaxine is not recommended as it can possibly result in an interaction, , but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 100 Tablet:
Using Tapentadol together with Zafimove 100 Tablet can increase the risk of high blood pressure and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Zafimove 100 Tablet and Tapentadol together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideDexmethylphenidate
Critical
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Dexmethylphenidate together may increase side effects such as blood pressure elevations and increased heart rate.

How to manage the interaction:
Taking Zafimove 100 Tablet with Dexmethylphenidate is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms like headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Milnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Milnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Vortioxetine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Vortioxetine with Zafimove 100 Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Buspirone can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Buspirone is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTryptophan
Critical
How does the drug interact with Zafimove 100 Tablet:
Taking Zafimove 100 Tablet with Tryptophan can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Tryptophan is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideFenfluramine
Critical
How does the drug interact with Zafimove 100 Tablet:
Coadministration of Zafimove 100 Tablet with Fenfluramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Fenfluramine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 100 Tablet:
Taking Procarbazine with Zafimove 100 Tablet can increase the risk of hypertension(High BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 100 Tablet with Procarbazine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Tyramine-rich foods: Eating foods with very high levels of tyramine, such as aged cheeses, cured meats, sauerkraut, or tap beers, can interact with this medicine and cause a dangerous increase in blood pressure.
SAFINAMIDE-100MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-100MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Zafimove 100 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Zafimove 100 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Zafimove 100 Tablet is used to treat the signs and symptoms of Parkinson's disease.
Zafimove 100 Tablet works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson's disease.
Yes, Zafimove 100 Tablet is not recommended in albinism (an inherited condition that causes a lack of colour in the skin, hair and eyes), retinal degeneration, uveitis (inflammation of the middle layer of the eye (uvea)), inherited retinopathy or severe progressive diabetic retinopathy.
Do not stop Zafimove 100 Tablet suddenly; it may cause side effects like confusion, stiff muscles and a high fever. So please consult your doctor before stopping the medicine.
The time it takes for Zafimove 100 Tablet to work can vary depending on the specific medication mechanism and the individual's health condition status.
In some individuals, Zafimove 100 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects do not require medical attention and gradually resolve over time. However, if any persists or worsens, please consult your doctor.
Zafimove 100 Tablet can be taken with a glass of water. Do not chew, break, or crush it. Follow your doctor's instructions regarding dose and duration and complete the entire course as prescribed.
Zafimove 100 Tablet belongs to pregnancy category C, which means that animal studies have shown potential risks to the fetus, but there are no good studies in pregnant women. As a result, the medication should only be used during pregnancy if the potential benefits justify the possible risks. Always consult your healthcare provider for personalized guidance.
You can take Zafimove 100 Tablet with or without food. However, it is important to be consistent and take it at the same time each day. Talk to your doctor or pharmacist if you have questions about how to take it.
You should avoid drinking alcohol while taking Zafimove 100 Tablet , as alcohol can increase your risk of experiencing side effects like extreme drowsiness, dizziness, and unpredictable blood pressure changes. Talk to your doctor for specific guidance.
Feeling dizzy or lightheaded when standing is common with Parkinson's treatments. Try to stand up very slowly from a sitting or lying position, and make sure you are drinking enough fluids throughout the day. If the dizziness is severe or does not improve, talk to your doctor.
Yes, especially if it is taken with certain interacting medications or foods extremely high in tyramine. Monitor your blood pressure regularly at home and report any sudden spikes or severe headaches to your healthcare provider immediately. Talk to your doctor for more details.
No, Zafimove 100 Tablet does not cure Parkinson's disease. Instead, it helps manage and control your symptoms, specifically by reducing "off" times and helping you move more easily when used alongside other treatments. Talk to your doctor about your long-term treatment plan.
If you see, hear, or feel things that are not there, or experience unusual changes in your behaviour or thinking, seek medical advice immediately. Do not stop taking your medication abruptly, but talk to your doctor right away for guidance.

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Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - ZAF0012
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