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compositionComposition:SAFINAMIDE-50MG
prescriptionPrescription Medicine
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's

Xafinact 50 Tablet is used in the treatment of Parkinson’s disease to help manage symptoms such as stiffness, tremors, and difficulty in movement. It helps improve motor control and supports smoother body movements, thereby enhancing daily functioning and quality of life in patients with Parkinson’s disease.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SAFINAMIDE-50MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Xafinact 50 Tablet

Xafinact 50 Tablet is used to treat the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion.

Xafinact 50 Tablet contains safinamide, which works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Take Xafinact 50 Tablet as advised by your doctor. Xafinact 50 Tablet may cause side effects like cough, indigestion, flu-like symptoms, difficulty sleeping, joint pain, and swelling. If the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Xafinact 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Xafinact 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor.

Uses of Xafinact 50 Tablet

Xafinact 50 Tablet used in the treatment of Parkinson's disease. The detailed uses of Xafinact 50 Tablet are as follows:

  • Treating Parkinson's Disease: Xafinact 50 Tablet is used along with levodopa/carbidopa to manage Parkinson's symptoms by boosting dopamine levels in the brain.

Key Benefits

  • Xafinact 50 Tablet helps in managing the signs and symptoms of Parkinson’s disease when used in combination with other antiparkinson medicines.
  • It reduces the frequency and duration of off episodes in patients with Parkinson’s disease.
  • Xafinact 50 Tablet improves motor function and movement control.
  • It supports better daily functioning and enhances the overall quality of life.
Side effects of Xafinact 50 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Pounding in the ears needs immediate medical attention when you hear abnormal sounds through your ears.
  • Get a physical examination, and an ENT will help identify factors that led to ear pounding.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and use a white noise machine to reduce the pounding sound in your ear. Soft music and low-volume radio can also help if there is no white noise machine.
  • Take a balanced diet and limit your intake of caffeine, alcohol and nicotine.

Directions for Use

  • Xafinact 50 Tablet can be taken with or without food.
  • It is recommended to take Xafinact 50 Tablet once daily at the same time each day or as advised by your doctor.
  • Swallow Xafinact 50 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Xafinact 50 Tablet Works

Xafinact 50 Tablet contains safinamide, which works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.
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Alcohol

Caution

Xafinact 50 Tablet may cause excessive drowsiness with alcohol, decreasing alertness and affecting your vision.

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Pregnancy

Unsafe

Xafinact 50 Tablet may be unsafe to use during pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Xafinact 50 Tablet . Please consult your doctor before taking Xafinact 50 Tablet .

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Breast Feeding

Unsafe

Xafinact 50 Tablet may be unsafe to use in breastfeeding mothers. Your doctor will weigh the benefits and potential risks before prescribing Xafinact 50 Tablet . Please consult your doctor before taking Xafinact 50 Tablet .

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Driving

Caution

Xafinact 50 Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Xafinact 50 Tablet should be used with caution in patients with liver disease. A dose adjustment of Xafinact 50 Tablet may be needed. So please consult your doctor before taking Xafinact 50 Tablet .

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Kidney

Caution

Xafinact 50 Tablet should be used with caution in patients with kidney disease. A dose adjustment of Xafinact 50 Tablet may be needed. So please consult your doctor before taking Xafinact 50 Tablet .

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Children

Unsafe

Xafinact 50 Tablet is not recommended for use in children under 12 years.

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Heart

Caution

Xafinact 50 Tablet should be used with extreme caution due to the risk of cardiovascular problems. Please inform your physician if you have any concerns.

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Geriatrics

Safe if prescribed

Xafinact 50 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Xafinact 50 Tablet

An overdose of Xafinact 50 Tablet may cause unpleasant effects. Seek immediate medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

Balanced Nutrition:

  • Follow a balanced diet that includes grains and leafy vegetables rich in vitamins, fibre, and minerals.
  • Include dairy products, protein-rich foods such as beans and meat, and healthy fats from nuts, olive oil, fish, and eggs.
  • Limit the consumption of sugar to support overall health.

Protein Intake Management:

  • Avoid excessive intake of high-protein foods such as soy protein, fish, eggs, chicken, beef, and pork.
  • Prefer whole-grain foods like whole wheat bread, oatmeal, brown rice, and whole-grain pasta.

Digestive Health:

  • Eat more fibre-rich foods to help relieve constipation.

Hydration:

  • Drink plenty of water to prevent dehydration-related headaches.

Health Queries

My father has been diagnosed with Parkinson's disease and is undergoing treatment with a neurologist.

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Your father should continue following his neurologist's treatment plan, as Parkinson's disease management requires regular monitoring and medication adjustments. Supportive care, such as physical therapy, exercise, and a balanced diet, can also help improve mobility and quality of life.

I sometimes notice my fingers shaking when holding cups or paper, but I am unaware of it. Could this indicate Parkinson's disease, and how is it diagnosed?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Unnoticed finger shaking while holding objects may be an early sign of tremor, but it does not always indicate Parkinson's disease. A neurologist diagnoses based on medical history, physical and neurological exams, and, when indicated, imaging or lab tests to rule out other causes.

Have a query?

How Soon It Starts Working

The time required for Xafinact 50 Tablet to start to work: Xafinact 50 Tablet ideally shows its action within 2 to 3 hours after administration.

The time for which the effects of Xafinact 50 Tablet last: The effect of Xafinact 50 Tablet lasts for 24 hours.

What if you forget to take Xafinact 50 Tablet

If you miss a dose of Xafinact 50 Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Xafinact 50 Tablet out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are known to be allergic to Xafinact 50 Tablet or any other medicines, please tell your doctor.
  • Please inform your doctor if you are using any medications other than Xafinact 50 Tablet .
  • If you are pregnant or breastfeeding, it is advised to inform your doctor.
  • Xafinact 50 Tablet is not recommended in albinism (a condition with less melanin) and eye problems like retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy.
  • Xafinact 50 Tablet should be used with caution in patients with schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems.
  • Xafinact 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour. Hence, talk to your doctor if you are taking any of these medicines.

Drug-Drug Interactions

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Drug-Drug Interaction: Inform your doctor if you are taking any of these medicines, as there may be an interaction.

  • Antidepressant (Doxepin, Imipramine)
    • Potential effect: May increase the risk of serotonin syndrome (a serious drug reaction)

Drug-Food Interaction: Xafinact 50 Tablet may interact with foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats, fish, and meats that are aged, dried, smoked, or fermented meats. Avoid consuming tyramine-rich foods while taking Xafinact 50 Tablet , as it may increase blood pressure levels.

Drug-Disease Interaction: Inform your doctor if you have any of these conditions.

  • Albinism (a condition with little or no pigment in the skin, hair, and eyes)
  • Retinal degeneration
  • Uveitis (eye inflammation)
  • Inherited retinopathy (inherited eye problem)
  • Severe progressive diabetic retinopathy (eye damage caused by long-term diabetes that worsens over time)
SafinamideFenfluramine
Critical
SafinamideLevomilnacipran
Critical

Drug-Drug Interactions

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SafinamideFenfluramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Xafinact 50 Tablet with Fenfluramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Fenfluramine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideLevomilnacipran
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with levomilnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with levomilnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideMethyldopa
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet and Methyldopa together can increase the risk of high blood pressure or brain related problems.

How to manage the interaction:
Taking Xafinact 50 Tablet with Methyldopa is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without first consulting your doctor.
SafinamideVenlafaxine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Venlafaxine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Venlafaxine is not recommended as it can possibly result in an interaction, , but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideProcarbazine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Procarbazine with Xafinact 50 Tablet can increase the risk of hypertension(High BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Procarbazine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTramadol
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Tramadol can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Tramadol is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTryptophan
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Tryptophan can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Tryptophan is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideBuspirone
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Buspirone can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Buspirone is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideVilazodone
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Amitriptyline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Vilazodone with Xafinact 50 Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as severe confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
SafinamideDoxepin
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Amitriptyline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Doxepin with Xafinact 50 Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Xafinact 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Xafinact 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIPARKINSON AGENTS]

FAQs

Xafinact 50 Tablet is used to treat the signs and symptoms of Parkinson's disease.

Xafinact 50 Tablet works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson's disease.

Yes, Xafinact 50 Tablet is not recommended in albinism (an inherited condition that causes a lack of colour in the skin, hair and eyes), retinal degeneration, uveitis (inflammation of the middle layer of the eye (uvea)), inherited retinopathy or severe progressive diabetic retinopathy.

Do not stop Xafinact 50 Tablet suddenly; it may cause side effects like confusion, stiff muscles and a high fever. So please consult your doctor before stopping the medicine.

The time it takes for Xafinact 50 Tablet to work can vary depending on the specific medication mechanism and the individual's health condition status.

In some individuals, Xafinact 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects do not require medical attention and gradually resolve over time. However, if any persists or worsens, please consult your doctor.

Xafinact 50 Tablet can be taken with a glass of water. Do not chew, break, or crush it. Follow your doctor's instructions regarding dose and duration and complete the entire course as prescribed.

Xafinact 50 Tablet belongs to pregnancy category C, which means that animal studies have shown potential risks to the fetus, but there are no good studies in pregnant women. As a result, the medication should only be used during pregnancy if the potential benefits justify the possible risks. Always consult your healthcare provider for personalized guidance.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - XAF0005
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